ID   PLET1_MESAU             Reviewed;         242 AA.
AC   Q5W9T8;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Placenta-expressed transcript 1 protein;
DE   AltName: Full=Antigen AgK114;
DE   Flags: Precursor;
GN   Name=PLET1;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=15516716; DOI=10.1248/bpb.27.1742;
RA   Tatefuji T., Arai C., Okura T., Kayano T., Mori T., Takakura-Yamamoto R.,
RA   Takeuchi M., Ohta T., Kurimoto M.;
RT   "Identification of the novel membrane-associated protein AgK114 on hamster
RT   keratinocytes recognized by a monoclonal antibody K114.";
RL   Biol. Pharm. Bull. 27:1742-1749(2004).
CC   -!- FUNCTION: Modulates leading keratinocyte migration and cellular
CC       adhesion to matrix proteins during a wound-healing response and
CC       promotes wound repair. May play a role during trichilemmal
CC       differentiation of the hair follicle (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Lipid-anchor,
CC       GPI-anchor {ECO:0000250}. Note=Localized at the apical membrane of the
CC       most differentiated keratinocytes of the outer root sheath (ORS),
CC       clustered mainly in planar regions of the plasma membrane at the base
CC       of microvilli. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Present at high level in the dermal sheath cells
CC       near the bulge area of the hair follicle and in the differentiated
CC       sebocytes of the normal adult skin (at protein level).
CC       {ECO:0000269|PubMed:15516716}.
CC   -!- INDUCTION: Following tissue damages of the skin.
CC       {ECO:0000269|PubMed:15516716}.
CC   -!- PTM: N-glycosylated. {ECO:0000250}.
CC   -!- PTM: GPI-anchored. {ECO:0000250}.
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DR   EMBL; AB154828; BAD69587.1; -; mRNA.
DR   AlphaFoldDB; Q5W9T8; -.
DR   STRING; 10036.XP_005069349.1; -.
DR   eggNOG; ENOG502RTZP; Eukaryota.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0001953; P:negative regulation of cell-matrix adhesion; ISS:UniProtKB.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0035313; P:wound healing, spreading of epidermal cells; ISS:UniProtKB.
DR   InterPro; IPR026184; PLET1.
DR   PANTHER; PTHR22527; PTHR22527; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Differentiation; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Reference proteome; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..223
FT                   /note="Placenta-expressed transcript 1 protein"
FT                   /id="PRO_0000320953"
FT   PROPEP          224..242
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000424668"
FT   LIPID           223
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        47
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        56
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        66
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   242 AA;  25595 MW;  223D190D747E1E8F CRC64;
     MAVLRSLLPQ LGLFLCLALC FSPALSASYN DPCTVFDTIS TTNLRVNITA EGSGENITYT
     VWVHVNSSVS VVILKAVNQD NKPVGTWVGA TQECNDSSVL YRVTPSDNSD FQATWIVPNS
     EDITKVNLHV LMAIGNGTAA VTSVNLGEPQ TSTPLRPTPE ISETNQTTTM TTDKTPAMTT
     AKTPAMTTAK TTAKTTAKTT VKTTAMTTAK TTAKSLAVNA LGSPLAGALH ILLVFLISKL
     LF