ID   PLET1_PIG               Reviewed;         210 AA.
AC   Q7YQE5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Placenta-expressed transcript 1 protein;
DE   Flags: Precursor;
GN   Name=PLET1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15203209; DOI=10.1016/j.ygeno.2004.02.006;
RA   Zhao S.-H., Simmons D.G., Cross J.C., Scheetz T.E., Casavant T.L.,
RA   Soares M.B., Tuggle C.K.;
RT   "PLET1 (C11orf34), a highly expressed and processed novel gene in pig and
RT   mouse placenta, is transcribed but poorly spliced in human.";
RL   Genomics 84:114-125(2004).
CC   -!- FUNCTION: Modulates leading keratinocyte migration and cellular
CC       adhesion to matrix proteins during a wound-healing response and
CC       promotes wound repair. May play a role during trichilemmal
CC       differentiation of the hair follicle (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250}.
CC       Note=Localized at the apical membrane of the most differentiated
CC       keratinocytes of the outer root sheath (ORS), clustered mainly in
CC       planar regions of the plasma membrane at the base of microvilli.
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in placenta.
CC   -!- CAUTION: For human, rat and golden hamster orthologs, a GPI-anchor has
CC       been predicted. However, in the case of pig and bovine, no GPI-anchor
CC       motifs have been detected, but it does not rule out the possibility of
CC       a GPI-anchor instead of a single-pass type I membrane protein.
CC       {ECO:0000305}.
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DR   EMBL; AY351651; AAQ02669.1; -; mRNA.
DR   EMBL; AY351652; AAQ02670.1; -; mRNA.
DR   RefSeq; NP_998909.1; NM_213744.1.
DR   AlphaFoldDB; Q7YQE5; -.
DR   STRING; 9823.ENSSSCP00000015966; -.
DR   PaxDb; Q7YQE5; -.
DR   PRIDE; Q7YQE5; -.
DR   Ensembl; ENSSSCT00025064554; ENSSSCP00025027493; ENSSSCG00025047472.
DR   Ensembl; ENSSSCT00035038384; ENSSSCP00035015319; ENSSSCG00035029012.
DR   Ensembl; ENSSSCT00040088386; ENSSSCP00040038847; ENSSSCG00040064721.
DR   Ensembl; ENSSSCT00045009592; ENSSSCP00045006550; ENSSSCG00045005768.
DR   Ensembl; ENSSSCT00050024535; ENSSSCP00050010265; ENSSSCG00050018071.
DR   Ensembl; ENSSSCT00055023814; ENSSSCP00055018838; ENSSSCG00055012165.
DR   Ensembl; ENSSSCT00065022278; ENSSSCP00065009038; ENSSSCG00065016779.
DR   Ensembl; ENSSSCT00070015611; ENSSSCP00070012917; ENSSSCG00070008080.
DR   GeneID; 396570; -.
DR   KEGG; ssc:396570; -.
DR   CTD; 349633; -.
DR   eggNOG; ENOG502RTZP; Eukaryota.
DR   HOGENOM; CLU_099483_1_0_1; -.
DR   InParanoid; Q7YQE5; -.
DR   OrthoDB; 1472106at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Chromosome 9.
DR   GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0001953; P:negative regulation of cell-matrix adhesion; ISS:UniProtKB.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0035313; P:wound healing, spreading of epidermal cells; ISS:UniProtKB.
DR   InterPro; IPR026184; PLET1.
DR   PANTHER; PTHR22527; PTHR22527; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Differentiation; Glycoprotein; Membrane; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..210
FT                   /note="Placenta-expressed transcript 1 protein"
FT                   /id="PRO_0000320955"
FT   TOPO_DOM        27..189
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        210
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   210 AA;  23255 MW;  8DDBC8A193066114 CRC64;
     MAVLGSPLLP LRLFLCFGLL FFSASCTDHP DQCMIFNKVT SIHNSRIQVN PKVYESNTVY
     TVSVPVNNTI SSVVMKAVDM HHSVIGFWQK ADMNCTSSAL YHVKSPHEHV LEAKWLSPAS
     TNINTVELQV FVVDFHKEAT ASVLKLEKSG TSPALITKLI TTKSNTVTTT KPTVITTHTT
     HKNSANRVFR SPVRDAIQIL LAFLTSKLLF