ID   PLET1_RAT               Reviewed;         255 AA.
AC   Q5HZW7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Placenta-expressed transcript 1 protein;
DE   Flags: Precursor;
GN   Name=Plet1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Modulates leading keratinocyte migration and cellular
CC       adhesion to matrix proteins during a wound-healing response and
CC       promotes wound repair. May play a role during trichilemmal
CC       differentiation of the hair follicle (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Lipid-anchor,
CC       GPI-anchor {ECO:0000250}. Note=Localized at the apical membrane of the
CC       most differentiated keratinocytes of the outer root sheath (ORS),
CC       clustered mainly in planar regions of the plasma membrane at the base
CC       of microvilli. {ECO:0000250}.
CC   -!- PTM: N-glycosylated. {ECO:0000250}.
CC   -!- PTM: GPI-anchored. {ECO:0000250}.
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DR   EMBL; BC088858; AAH88858.1; -; mRNA.
DR   RefSeq; NP_001014231.1; NM_001014209.1.
DR   AlphaFoldDB; Q5HZW7; -.
DR   STRING; 10116.ENSRNOP00000055980; -.
DR   GlyGen; Q5HZW7; 3 sites.
DR   PaxDb; Q5HZW7; -.
DR   GeneID; 363060; -.
DR   KEGG; rno:363060; -.
DR   UCSC; RGD:1359217; rat.
DR   CTD; 349633; -.
DR   RGD; 1359217; Plet1.
DR   VEuPathDB; HostDB:ENSRNOG00000024346; -.
DR   eggNOG; ENOG502RTZP; Eukaryota.
DR   HOGENOM; CLU_099483_0_0_1; -.
DR   InParanoid; Q5HZW7; -.
DR   OMA; FIVINRT; -.
DR   OrthoDB; 1472106at2759; -.
DR   PhylomeDB; Q5HZW7; -.
DR   TreeFam; TF344172; -.
DR   Reactome; R-RNO-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR   PRO; PR:Q5HZW7; -.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000024346; Expressed in ovary and 13 other tissues.
DR   Genevisible; Q5HZW7; RN.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR   GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0001953; P:negative regulation of cell-matrix adhesion; ISS:UniProtKB.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0035313; P:wound healing, spreading of epidermal cells; ISS:UniProtKB.
DR   InterPro; IPR026184; PLET1.
DR   PANTHER; PTHR22527; PTHR22527; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Differentiation; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Reference proteome; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..236
FT                   /note="Placenta-expressed transcript 1 protein"
FT                   /id="PRO_0000320956"
FT   PROPEP          237..255
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000424670"
FT   LIPID           236
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        57
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        126
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   255 AA;  26849 MW;  FD5E1B2EB8CB7091 CRC64;
     MPALRTLLPH LGLFLCLALC FSPSFSLSNN ESCILYDQVY PSDNLINASA EEVSGENTTY
     TVTVPVNDSV SAVILKAEKD NKPVGTWSGA YEKCNNSVVY NLTSLNNSAF QTNWTVPSSE
     DVTKVNLTIF IVINRTATVS SVKLEPKETS SLASTPESQT SAMTTAMTSA MTTAKTTAVA
     TNSSTDVTSD NSTAVTTANS TAVTTANSTA VTTAKTTTMT TATTTAKSLA IRTLCSPLAG
     ALHILLVFLI SKLLF