PLET2_ARATH
ID PLET2_ARATH Reviewed; 568 AA.
AC Q5YGP7; Q6PQQ7; Q9SYC2;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=AP2-like ethylene-responsive transcription factor PLT2 {ECO:0000303|PubMed:15454085};
DE AltName: Full=Protein AINTEGUMENTA-LIKE 4 {ECO:0000303|PubMed:15988559};
DE AltName: Full=Protein PLETHORA 2 {ECO:0000303|PubMed:15454085};
GN Name=PLT2 {ECO:0000303|PubMed:15454085};
GN Synonyms=AIL4 {ECO:0000303|PubMed:15988559};
GN OrderedLocusNames=At1g51190 {ECO:0000312|Araport:AT1G51190};
GN ORFNames=F11M15.6 {ECO:0000312|EMBL:AAD30633.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, SUBCELLULAR LOCATION, AND INDUCTION.
RC STRAIN=cv. Columbia;
RX PubMed=15454085; DOI=10.1016/j.cell.2004.09.018;
RA Aida M., Beis D., Heidstra R., Willemsen V., Blilou I., Galinha C.,
RA Nussaume L., Noh Y.-S., Amasino R., Scheres B.;
RT "The PLETHORA genes mediate patterning of the Arabidopsis root stem cell
RT niche.";
RL Cell 119:109-120(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Pan Y., Gong W., Liu D., Fu Q., Mei W.-Q., Song W.-Q., Ma L.-G., Luo J.-C.,
RA Deng X.-W., Zhu Y.-X.;
RT "Molecular cloning, expression, phylogenetic and functional
RT characterization of the Arabidopsis AP2/EREBP transcription factor
RT family.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=15635403; DOI=10.1038/nature03184;
RA Blilou I., Xu J., Wildwater M., Willemsen V., Paponov I., Friml J.,
RA Heidstra R., Aida M., Palme K., Scheres B.;
RT "The PIN auxin efflux facilitator network controls growth and patterning in
RT Arabidopsis roots.";
RL Nature 433:39-44(2005).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=15988559; DOI=10.1007/s11103-005-0955-6;
RA Nole-Wilson S., Tranby T.L., Krizek B.A.;
RT "AINTEGUMENTA-like (AIL) genes are expressed in young tissues and may
RT specify meristematic or division-competent states.";
RL Plant Mol. Biol. 57:613-628(2005).
RN [8]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16407444; DOI=10.1104/pp.105.073783;
RA Nakano T., Suzuki K., Fujimura T., Shinshi H.;
RT "Genome-wide analysis of the ERF gene family in Arabidopsis and rice.";
RL Plant Physiol. 140:411-432(2006).
RN [9]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16424342; DOI=10.1126/science.1121790;
RA Xu J., Hofhuis H., Heidstra R., Sauer M., Friml J., Scheres B.;
RT "A molecular framework for plant regeneration.";
RL Science 311:385-388(2006).
RN [10]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=20190735; DOI=10.1038/nature08843;
RA Smith Z.R., Long J.A.;
RT "Control of Arabidopsis apical-basal embryo polarity by antagonistic
RT transcription factors.";
RL Nature 464:423-426(2010).
RN [11]
RP REGULATION BY RGF.
RX PubMed=20798316; DOI=10.1126/science.1191132;
RA Matsuzaki Y., Ogawa-Ohnishi M., Mori A., Matsubayashi Y.;
RT "Secreted peptide signals required for maintenance of root stem cell niche
RT in Arabidopsis.";
RL Science 329:1065-1067(2010).
RN [12]
RP PTM.
RC STRAIN=cv. Columbia;
RX PubMed=31801996; DOI=10.1038/s41586-019-1819-6;
RA Yamada M., Han X., Benfey P.N.;
RT "RGF1 controls root meristem size through ROS signalling.";
RL Nature 577:85-88(2020).
CC -!- FUNCTION: Probably acts as a transcriptional activator. Binds to the
CC GCC-box pathogenesis-related promoter element. May be involved in the
CC regulation of gene expression by stress factors and by components of
CC stress signal transduction pathways (By similarity). Master regulator
CC of basal/root fate. Essential for root quiescent center (QC) and
CC columella specification, stem cell activity, as well as for
CC establishment of the stem cell niche during embryogenesis. Modulates
CC the root polar auxin transport by regulating the distribution of PIN
CC genes. Essential role in respecifying pattern and polarity in damaged
CC roots. Direct target of the transcriptional corepressor TPL. Expression
CC levels and patterns regulated post-transcriptionally by root meristem
CC growth factors (RGFs). {ECO:0000250|UniProtKB:Q9LND1,
CC ECO:0000269|PubMed:15454085, ECO:0000269|PubMed:15635403,
CC ECO:0000269|PubMed:16424342, ECO:0000269|PubMed:20190735}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00366,
CC ECO:0000269|PubMed:15454085}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, seedlings, flowers, and
CC siliques. Also detected at low levels in leaves. In roots, specifically
CC detected in the distal root meristem, including the QC. This tissue
CC specificity is regulated by auxin gradient and depends on PIN proteins.
CC {ECO:0000269|PubMed:15454085, ECO:0000269|PubMed:15635403,
CC ECO:0000269|PubMed:15988559, ECO:0000269|PubMed:16424342,
CC ECO:0000269|PubMed:20190735}.
CC -!- DEVELOPMENTAL STAGE: Accumulates in the basal embryo region that gives
CC rise to hypocotyl, root, and root stem cells. Expressed in the root
CC meristem throughout embryo development. {ECO:0000269|PubMed:15454085,
CC ECO:0000269|PubMed:20190735}.
CC -!- INDUCTION: By auxin accumulation. {ECO:0000269|PubMed:15454085}.
CC -!- PTM: Stabilized in root meristems by reactive oxygen species (ROS)
CC mediated oxidative post-translational modification triggered by RGF1
CC hormone peptide in a RITF1-dependent manner.
CC {ECO:0000269|PubMed:31801996}.
CC -!- SIMILARITY: Belongs to the AP2/ERF transcription factor family. AP2
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD30633.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY506550; AAS86336.1; -; mRNA.
DR EMBL; AY585681; AAS97938.1; -; mRNA.
DR EMBL; AC006085; AAD30633.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE32632.1; -; Genomic_DNA.
DR EMBL; BT020277; AAV84498.1; -; mRNA.
DR EMBL; BT020460; AAW30038.1; -; mRNA.
DR PIR; F96549; F96549.
DR RefSeq; NP_175530.2; NM_103997.4.
DR AlphaFoldDB; Q5YGP7; -.
DR BioGRID; 26767; 2.
DR IntAct; Q5YGP7; 2.
DR STRING; 3702.AT1G51190.1; -.
DR PaxDb; Q5YGP7; -.
DR PRIDE; Q5YGP7; -.
DR ProteomicsDB; 234671; -.
DR EnsemblPlants; AT1G51190.1; AT1G51190.1; AT1G51190.
DR GeneID; 841542; -.
DR Gramene; AT1G51190.1; AT1G51190.1; AT1G51190.
DR KEGG; ath:AT1G51190; -.
DR Araport; AT1G51190; -.
DR TAIR; locus:2008216; AT1G51190.
DR eggNOG; ENOG502QSTN; Eukaryota.
DR HOGENOM; CLU_013549_5_0_1; -.
DR InParanoid; Q5YGP7; -.
DR OMA; TCETSGE; -.
DR OrthoDB; 455685at2759; -.
DR PhylomeDB; Q5YGP7; -.
DR PRO; PR:Q5YGP7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q5YGP7; baseline and differential.
DR Genevisible; Q5YGP7; AT.
DR GO; GO:0005634; C:nucleus; NAS:TAIR.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0010073; P:meristem maintenance; IGI:TAIR.
DR GO; GO:0007389; P:pattern specification process; IMP:TAIR.
DR GO; GO:0048364; P:root development; IMP:TAIR.
DR GO; GO:0010449; P:root meristem growth; IGI:TAIR.
DR GO; GO:0019827; P:stem cell population maintenance; IMP:TAIR.
DR GO; GO:0000723; P:telomere maintenance; IDA:TAIR.
DR CDD; cd00018; AP2; 2.
DR Gene3D; 3.30.730.10; -; 2.
DR InterPro; IPR001471; AP2/ERF_dom.
DR InterPro; IPR036955; AP2/ERF_dom_sf.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR Pfam; PF00847; AP2; 2.
DR PRINTS; PR00367; ETHRSPELEMNT.
DR SMART; SM00380; AP2; 2.
DR SUPFAM; SSF54171; SSF54171; 2.
DR PROSITE; PS51032; AP2_ERF; 2.
PE 2: Evidence at transcript level;
KW Activator; Auxin signaling pathway; Developmental protein; DNA-binding;
KW Ethylene signaling pathway; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation.
FT CHAIN 1..568
FT /note="AP2-like ethylene-responsive transcription factor
FT PLT2"
FT /id="PRO_0000297931"
FT DNA_BIND 190..256
FT /note="AP2/ERF 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT DNA_BIND 292..350
FT /note="AP2/ERF 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00366"
FT REGION 151..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 80
FT /note="T -> P (in Ref. 2; AAS97938)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 568 AA; 62233 MW; 7C93903C46BE9029 CRC64;
MNSNNWLAFP LSPTHSSLPP HIHSSQNSHF NLGLVNDNID NPFQNQGWNM INPHGGGGEG
GEVPKVADFL GVSKSGDHHT DHNLVPYNDI HQTNASDYYF QTNSLLPTVV TCASNAPNNY
ELQESAHNLQ SLTLSMGSTG AAAAEVATVK ASPAETSADN SSSTTNTSGG AIVEATPRRT
LETFGQRTSI YRGVTRHRWT GRYEAHLWDN SCRREGQSRK GRQVYLGGYD KEEKAARAYD
LAALKYWGPS TTTNFPITNY EKEVEEMKNM TRQEFVASIR RKSSGFSRGA SMYRGVTRHH
QHGRWQARIG RVAGNKDLYL GTFSTEEEAA EAYDIAAIKF RGLNAVTNFE INRYDVKAIL
ESNTLPIGGG AAKRLKEAQA LESSRKREEM IALGSNFHQY GAASGSSSVA SSSRLQLQPY
PLSIQQPFEH LHHHQPLLTL QNNNDISQYH DSFSYIQTQL HLHQQQTNNY LQSSSHTSQL
YNAYLQSNPG LLHGFVSDNN NTSGFLGNNG IGIGSSSTVG SSAEEEFPAV KVDYDMPPSG
GATGYGGWNS GESAQGSNPG GVFTMWNE
