ID   PLF4_RABIT              Reviewed;          30 AA.
AC   P83470;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-2002, sequence version 1.
DT   23-FEB-2022, entry version 59.
DE   RecName: Full=Platelet factor 4;
DE            Short=PF-4;
DE   AltName: Full=C-X-C motif chemokine 4;
DE   Flags: Fragment;
GN   Name=PF4; Synonyms=CXCL4, SCYB4;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=New Zealand; TISSUE=Platelet;
RA   Santoro M.L., Barbaro K.C., Rocha T.R.F., Torquato R.J.S., Hirata I.Y.,
RA   Sano-Martins I.S.;
RT   "Platelet activation induced by Bothrops jararaca snake envenomation in
RT   rabbits.";
RL   Submitted (OCT-2002) to UniProtKB.
CC   -!- FUNCTION: Released during platelet aggregation. Neutralizes the
CC       anticoagulant effect of heparin because it binds more strongly to
CC       heparin than to the chondroitin-4-sulfate chains of the carrier
CC       molecule. Chemotactic for neutrophils and monocytes. Inhibits
CC       endothelial cell proliferation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotetramer. Interacts with TNFAIP6 (via Link domain).
CC       {ECO:0000250|UniProtKB:P02776}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Binds non-covalently to a proteoglycan molecule. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   eggNOG; ENOG502TF57; Eukaryota.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0048248; F:CXCR3 chemokine receptor binding; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0042127; P:regulation of cell population proliferation; ISS:UniProtKB.
PE   1: Evidence at protein level;
KW   Chemotaxis; Cytokine; Direct protein sequencing; Heparin-binding;
KW   Reference proteome; Secreted.
FT   CHAIN           1..>30
FT                   /note="Platelet factor 4"
FT                   /id="PRO_0000144300"
FT   VARIANT         20
FT                   /note="R -> S"
FT   VARIANT         25
FT                   /note="G -> T"
FT   NON_TER         30
SQ   SEQUENCE   30 AA;  3318 MW;  70C6D72CDA20DF98 CRC64;
     SDDPKESEGD LHCVCVKTTR LVRPGHITXL