PLGB_HUMAN
ID PLGB_HUMAN Reviewed; 96 AA.
AC Q02325; Q580R1;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Plasminogen-like protein B;
DE AltName: Full=Plasminogen-related protein B;
DE Flags: Precursor;
GN Name=PLGLB1; Synonyms=PLGL, PRGB;
GN and
GN Name=PLGLB2; Synonyms=PLGP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1379800; DOI=10.1016/0006-291x(92)90861-e;
RA Weissbach L., Treadwell B.V.;
RT "A plasminogen-related gene is expressed in cancer cells.";
RL Biochem. Biophys. Res. Commun. 186:1108-1114(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1554698; DOI=10.1021/bi00127a011;
RA Ichinose A.;
RT "Multiple members of the plasminogen-apolipoprotein(a) gene family
RT associated with thrombosis.";
RL Biochemistry 31:3113-3118(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver, and Skeletal muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May bind noncovalently to lysine binding sites present in the
CC kringle structures of plasminogen. This may interfere with the binding
CC of fibrin or alpha-2-antiplasmin to plasminogen and may result in the
CC localization of activity at sites necessary for extracellular matrix
CC destruction.
CC -!- SUBCELLULAR LOCATION: Secreted.
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DR EMBL; M93143; AAB06491.1; -; mRNA.
DR EMBL; M86876; AAA60169.1; -; Genomic_DNA.
DR EMBL; M86874; AAA60169.1; JOINED; Genomic_DNA.
DR EMBL; M86875; AAA60169.1; JOINED; Genomic_DNA.
DR EMBL; AC093616; AAX82025.1; -; Genomic_DNA.
DR EMBL; BC005379; AAH05379.1; -; mRNA.
DR EMBL; BC022294; AAH22294.1; -; mRNA.
DR EMBL; BC109248; AAI09249.1; -; mRNA.
DR CCDS; CCDS1999.1; -.
DR CCDS; CCDS33238.1; -.
DR PIR; JC1195; JC1195.
DR RefSeq; NP_001027564.1; NM_001032392.2.
DR RefSeq; NP_002656.1; NM_002665.4.
DR AlphaFoldDB; Q02325; -.
DR SMR; Q02325; -.
DR STRING; 9606.ENSP00000347933; -.
DR GlyGen; Q02325; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q02325; -.
DR PhosphoSitePlus; Q02325; -.
DR BioMuta; PLGLB1; -.
DR DMDM; 548594; -.
DR jPOST; Q02325; -.
DR MassIVE; Q02325; -.
DR PaxDb; Q02325; -.
DR PeptideAtlas; Q02325; -.
DR PRIDE; Q02325; -.
DR ProteomicsDB; 58081; -.
DR Antibodypedia; 32192; 19 antibodies from 10 providers.
DR Antibodypedia; 68816; 63 antibodies from 12 providers.
DR DNASU; 5342; -.
DR Ensembl; ENST00000355705.4; ENSP00000347933.3; ENSG00000183281.15.
DR Ensembl; ENST00000359481.9; ENSP00000352458.4; ENSG00000125551.19.
DR Ensembl; ENST00000409310.6; ENSP00000386505.2; ENSG00000183281.15.
DR Ensembl; ENST00000409801.5; ENSP00000386975.1; ENSG00000183281.15.
DR Ensembl; ENST00000410086.3; ENSP00000386317.3; ENSG00000125551.19.
DR GeneID; 5342; -.
DR GeneID; 5343; -.
DR KEGG; hsa:5342; -.
DR KEGG; hsa:5343; -.
DR MANE-Select; ENST00000355705.4; ENSP00000347933.3; NM_001032392.4; NP_001027564.1.
DR MANE-Select; ENST00000359481.9; ENSP00000352458.4; NM_002665.4; NP_002656.1.
DR UCSC; uc002ssd.4; human.
DR CTD; 5342; -.
DR CTD; 5343; -.
DR GeneCards; PLGLB1; -.
DR GeneCards; PLGLB2; -.
DR HGNC; HGNC:9072; PLGLB1.
DR HGNC; HGNC:9073; PLGLB2.
DR HPA; ENSG00000125551; Tissue enriched (liver).
DR HPA; ENSG00000183281; Tissue enriched (liver).
DR MIM; 173340; gene.
DR neXtProt; NX_Q02325; -.
DR OpenTargets; ENSG00000125551; -.
DR OpenTargets; ENSG00000183281; -.
DR PharmGKB; PA33406; -.
DR VEuPathDB; HostDB:ENSG00000125551; -.
DR VEuPathDB; HostDB:ENSG00000183281; -.
DR eggNOG; ENOG502QVNP; Eukaryota.
DR GeneTree; ENSGT00940000155208; -.
DR HOGENOM; CLU_189300_0_0_1; -.
DR OrthoDB; 1872575at2759; -.
DR PhylomeDB; Q02325; -.
DR TreeFam; TF344093; -.
DR PathwayCommons; Q02325; -.
DR BioGRID-ORCS; 5342; 339 hits in 914 CRISPR screens.
DR BioGRID-ORCS; 5343; 31 hits in 600 CRISPR screens.
DR GeneWiki; PLGLB2; -.
DR Pharos; Q02325; Tdark.
DR PRO; PR:Q02325; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q02325; protein.
DR Bgee; ENSG00000125551; Expressed in right lobe of liver and 94 other tissues.
DR ExpressionAtlas; Q02325; baseline and differential.
DR Genevisible; Q02325; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0036313; F:phosphatidylinositol 3-kinase catalytic subunit binding; IBA:GO_Central.
DR GO; GO:0043553; P:negative regulation of phosphatidylinositol 3-kinase activity; IBA:GO_Central.
DR GO; GO:0014067; P:negative regulation of phosphatidylinositol 3-kinase signaling; IBA:GO_Central.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR016351; Plasminogen-rel.
DR Pfam; PF00024; PAN_1; 1.
DR PIRSF; PIRSF002483; Plasminogen-related; 1.
DR SMART; SM00473; PAN_AP; 1.
DR PROSITE; PS50948; PAN; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000250"
FT CHAIN 20..96
FT /note="Plasminogen-like protein B"
FT /id="PRO_0000022105"
FT DOMAIN 20..96
FT /note="PAN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00315"
FT DISULFID 49..73
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00315"
FT DISULFID 53..61
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00315"
SQ SEQUENCE 96 AA; 10971 MW; 8D8073F529F2716D CRC64;
MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG PSLFSVTKKQ LGAGSREECA AKCEEDKEFT
CRAFQYHSKE QQCVIMAENR KSSIIIRMRD AVLFEK
