ID   PLGF_BOVIN              Reviewed;         149 AA.
AC   Q9XS47; Q2KII8;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Placenta growth factor;
DE            Short=PlGF;
DE   Flags: Precursor;
GN   Name=PGF; Synonyms=PLGF;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RA   Liu X., Yonekura H., Yamagishi S., Yamamoto Y., Yamamoto H.;
RT   "Structure and expression of bovine VEGF family.";
RL   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Growth factor active in angiogenesis and endothelial cell
CC       growth, stimulating their proliferation and migration. It binds to the
CC       receptor FLT1/VEGFR-1. Also promotes cell tumor growth (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Antiparallel homodimer; disulfide-linked. Also found as
CC       heterodimer with VEGFA/VEGF (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC       {ECO:0000305}.
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DR   EMBL; AB004272; BAA77684.1; -; mRNA.
DR   EMBL; BC112622; AAI12623.1; -; mRNA.
DR   RefSeq; NP_776375.1; NM_173950.2.
DR   AlphaFoldDB; Q9XS47; -.
DR   SMR; Q9XS47; -.
DR   STRING; 9913.ENSBTAP00000018196; -.
DR   PaxDb; Q9XS47; -.
DR   Ensembl; ENSBTAT00000018196; ENSBTAP00000018196; ENSBTAG00000013688.
DR   GeneID; 280894; -.
DR   KEGG; bta:280894; -.
DR   CTD; 5228; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013688; -.
DR   VGNC; VGNC:32787; PGF.
DR   eggNOG; ENOG502S2DE; Eukaryota.
DR   GeneTree; ENSGT00940000160164; -.
DR   HOGENOM; CLU_042996_1_0_1; -.
DR   InParanoid; Q9XS47; -.
DR   OrthoDB; 1364454at2759; -.
DR   TreeFam; TF319554; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000013688; Expressed in cumulus cell and 95 other tissues.
DR   ExpressionAtlas; Q9XS47; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
DR   GO; GO:0005172; F:vascular endothelial growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0050930; P:induction of positive chemotaxis; IBA:GO_Central.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IBA:GO_Central.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IBA:GO_Central.
DR   GO; GO:0060754; P:positive regulation of mast cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IBA:GO_Central.
DR   GO; GO:0002040; P:sprouting angiogenesis; IBA:GO_Central.
DR   GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0038084; P:vascular endothelial growth factor signaling pathway; IBA:GO_Central.
DR   CDD; cd00135; PDGF; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR023581; PD_growth_factor_CS.
DR   InterPro; IPR000072; PDGF/VEGF_dom.
DR   Pfam; PF00341; PDGF; 1.
DR   SMART; SM00141; PDGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00249; PDGF_1; 1.
DR   PROSITE; PS50278; PDGF_2; 1.
PE   2: Evidence at transcript level;
KW   Angiogenesis; Developmental protein; Differentiation; Disulfide bond;
KW   Glycoprotein; Growth factor; Mitogen; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..149
FT                   /note="Placenta growth factor"
FT                   /id="PRO_0000023419"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        101
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        52..94
FT                   /evidence="ECO:0000250"
FT   DISULFID        77
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   DISULFID        83..128
FT                   /evidence="ECO:0000250"
FT   DISULFID        86
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
FT   DISULFID        87..130
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   149 AA;  17094 MW;  1F8EE3BBC745EFE0 CRC64;
     MPTVRLFTCF LQLLTGLVLP AVPTTQWALS PGNISSEVEV VPFQQVWSRS YCRPVERLVD
     IVSEYPSEME HLFSPSCVSL MRCTGCCSDE SMHCVPLETA NVTMQLMKYR SLDQPFFVEM
     SFSQHVRCEC KPLWEKMKQT RCGDTISQR