PLGF_RAT
ID PLGF_RAT Reviewed; 158 AA.
AC Q63434;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Placenta growth factor;
DE Short=PlGF;
DE Flags: Precursor;
GN Name=Pgf; Synonyms=Plgf;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND
RP HETERODIMERIZATION WITH VEGFA.
RX PubMed=7706320; DOI=10.1074/jbc.270.13.7717;
RA DiSalvo J., Bayne M.L., Conn G., Kwok P.W., Trivedi P.G., Soderman D.D.,
RA Palisi T.M., Sullivan K.A., Thomas K.A.;
RT "Purification and characterization of a naturally occurring vascular
RT endothelial growth factor.placenta growth factor heterodimer.";
RL J. Biol. Chem. 270:7717-7723(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Growth factor active in angiogenesis and endothelial cell
CC growth, stimulating their proliferation and migration. It binds to the
CC receptor FLT1/VEGFR-1. Also promotes cell tumor growth (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Antiparallel homodimer; disulfide-linked. Also found as
CC heterodimer with VEGFA/VEGF.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000305}.
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DR EMBL; L40030; AAA97426.1; -; mRNA.
DR EMBL; BC087006; AAH87006.1; -; mRNA.
DR PIR; A56125; A56125.
DR RefSeq; NP_446047.1; NM_053595.2.
DR AlphaFoldDB; Q63434; -.
DR SMR; Q63434; -.
DR STRING; 10116.ENSRNOP00000007790; -.
DR GlyGen; Q63434; 3 sites.
DR PaxDb; Q63434; -.
DR GeneID; 94203; -.
DR KEGG; rno:94203; -.
DR UCSC; RGD:619850; rat.
DR CTD; 5228; -.
DR RGD; 619850; Pgf.
DR VEuPathDB; HostDB:ENSRNOG00000005650; -.
DR eggNOG; ENOG502S2DE; Eukaryota.
DR HOGENOM; CLU_042996_3_0_1; -.
DR InParanoid; Q63434; -.
DR OMA; KQCECRP; -.
DR OrthoDB; 1364454at2759; -.
DR PhylomeDB; Q63434; -.
DR TreeFam; TF319554; -.
DR Reactome; R-RNO-194313; VEGF ligand-receptor interactions.
DR Reactome; R-RNO-195399; VEGF binds to VEGFR leading to receptor dimerization.
DR PRO; PR:Q63434; -.
DR Proteomes; UP000002494; Chromosome 6.
DR Bgee; ENSRNOG00000005650; Expressed in skeletal muscle tissue and 17 other tissues.
DR Genevisible; Q63434; RN.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IPI:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; IDA:RGD.
DR GO; GO:0005172; F:vascular endothelial growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0031100; P:animal organ regeneration; IEP:RGD.
DR GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; ISO:RGD.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0032870; P:cellular response to hormone stimulus; IEP:RGD.
DR GO; GO:0007565; P:female pregnancy; IEP:RGD.
DR GO; GO:0050930; P:induction of positive chemotaxis; IBA:GO_Central.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IDA:RGD.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IMP:RGD.
DR GO; GO:0060754; P:positive regulation of mast cell chemotaxis; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0060688; P:regulation of morphogenesis of a branching structure; ISO:RGD.
DR GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR GO; GO:0002040; P:sprouting angiogenesis; IDA:RGD.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0038084; P:vascular endothelial growth factor signaling pathway; IBA:GO_Central.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR023581; PD_growth_factor_CS.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00141; PDGF; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00249; PDGF_1; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 1: Evidence at protein level;
KW Angiogenesis; Developmental protein; Differentiation;
KW Direct protein sequencing; Disulfide bond; Glycoprotein; Growth factor;
KW Mitogen; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /note="Or 26"
FT CHAIN 24..158
FT /note="Placenta growth factor"
FT /id="PRO_0000023422"
FT REGION 136..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT DISULFID 48..90
FT /evidence="ECO:0000250"
FT DISULFID 73
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT DISULFID 79..125
FT /evidence="ECO:0000250"
FT DISULFID 82
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT DISULFID 83..127
FT /evidence="ECO:0000250"
SQ SEQUENCE 158 AA; 17681 MW; B4771373A82E15B9 CRC64;
MLAMKLFTCF LQVLAGLAVH SQGALSAGNN STEMEVVPFN EVWGRSYCRP MEKLVYIADE
HPNEVSHIFS PSCVLLSRCS GCCGDEGLHC VALKTANITM QILKIPPNRD PHSYVEMTFS
QDVLCECRPI LETTKAERRK TKGKRKQSKT PQTEEPHL
