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PLH9_FORAG
ID   PLH9_FORAG              Reviewed;         353 AA.
AC   T2KMF9;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2013, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=6-phosphogluconolactonase {ECO:0000303|PubMed:31285597};
DE            EC=3.1.1.31 {ECO:0000250|UniProtKB:O34499};
DE   AltName: Full=P9_lactonase {ECO:0000303|PubMed:31285597};
DE   AltName: Full=Polysaccharide utilization locus H protein P9 {ECO:0000303|PubMed:31285597};
DE            Short=PUL H protein P9;
GN   Name=pgl; ORFNames=BN863_21980;
OS   Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 /
OS   M-2Alg 35-1).
OC   Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Formosa.
OX   NCBI_TaxID=1347342;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1;
RX   PubMed=23995932; DOI=10.1128/aem.01937-13;
RA   Mann A.J., Hahnke R.L., Huang S., Werner J., Xing P., Barbeyron T.,
RA   Huettel B., Stueber K., Reinhardt R., Harder J., Gloeckner F.O.,
RA   Amann R.I., Teeling H.;
RT   "The genome of the alga-associated marine flavobacterium Formosa agariphila
RT   KMM 3901T reveals a broad potential for degradation of algal
RT   polysaccharides.";
RL   Appl. Environ. Microbiol. 79:6813-6822(2013).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX   PubMed=31285597; DOI=10.1038/s41589-019-0311-9;
RA   Reisky L., Prechoux A., Zuehlke M.K., Baeumgen M., Robb C.S., Gerlach N.,
RA   Roret T., Stanetty C., Larocque R., Michel G., Song T., Markert S.,
RA   Unfried F., Mihovilovic M.D., Trautwein-Schult A., Becher D., Schweder T.,
RA   Bornscheuer U.T., Hehemann J.H.;
RT   "A marine bacterial enzymatic cascade degrades the algal polysaccharide
RT   ulvan.";
RL   Nat. Chem. Biol. 15:803-812(2019).
CC   -!- FUNCTION: Carboxylic ester hydrolase that may be involved in ulvan
CC       degradation (Probable). Ulvan is the main polysaccharide component of
CC       the Ulvales (green seaweed) cell wall. It is composed of disaccharide
CC       building blocks comprising 3-sulfated rhamnose (Rha3S) linked to D-
CC       glucuronic acid (GlcA), L-iduronic acid (IduA), or D-xylose (Xyl)
CC       (Probable). Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-
CC       phosphogluconate (By similarity). {ECO:0000250|UniProtKB:O34499,
CC       ECO:0000305|PubMed:31285597}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC         + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC         Evidence={ECO:0000250|UniProtKB:O34499};
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC       2/3. {ECO:0000250|UniProtKB:O34499}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31285597}.
CC   -!- INDUCTION: By ulvan and rhamnose. {ECO:0000269|PubMed:31285597}.
CC   -!- SIMILARITY: Belongs to the cycloisomerase 2 family. {ECO:0000305}.
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DR   EMBL; HG315671; CDF79910.1; -; Genomic_DNA.
DR   AlphaFoldDB; T2KMF9; -.
DR   SMR; T2KMF9; -.
DR   STRING; 1347342.BN863_21980; -.
DR   EnsemblBacteria; CDF79910; CDF79910; BN863_21980.
DR   PATRIC; fig|1347342.6.peg.2205; -.
DR   eggNOG; COG2706; Bacteria.
DR   HOGENOM; CLU_038716_3_0_10; -.
DR   OMA; NGPHAHM; -.
DR   UniPathway; UPA00115; UER00409.
DR   Proteomes; UP000016160; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR011048; Haem_d1_sf.
DR   InterPro; IPR019405; Lactonase_7-beta_prop.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF10282; Lactonase; 1.
DR   SUPFAM; SSF51004; SSF51004; 1.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism; Cytoplasm; Glucose metabolism; Hydrolase;
KW   Reference proteome.
FT   CHAIN           1..353
FT                   /note="6-phosphogluconolactonase"
FT                   /id="PRO_0000448308"
SQ   SEQUENCE   353 AA;  39035 MW;  06D6BF1DA37808EE CRC64;
     MFVGSFTDKK PGTGIHVFDF NTKSGEAQLL SEVDSIINSS FLKLSPNGKY LYSVIESQLQ
     THGKIAAFKI DSNAGDLKLI NMQDCGGRNP AHIEIDKSGK FLAVSNYTDP SLSFFEVDET
     GKIKKIDEFF TFTGSGIVKG NQDTAHIHSS NFSLENDYLF LQDLGSDCIH KFKVNLDANQ
     NMSLQKADAI KVKPGSGPRH FVFHQNGKYG YGINELSGKV SAYALLNGNL KFLADYNAYS
     KKQDSYRSAD IHISPDGKFL YASNRGPNED SIVIFSINKS NGALKLIGHE PTYGEHPRNF
     AIDPSGQFLL VANQFSNNIV IFRRDVETGK LQKLPQELVV NGSSSLQMFT YSH
 
 
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