ID   PLHD1_CAEEL             Reviewed;         570 AA.
AC   O45420; B7WNA6; B7WNA7;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 2.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Pleckstrin homology domain-containing family D member 1;
DE            Short=PH domain-containing family D member 1;
GN   ORFNames=F31D4.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=O45420-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=O45420-2; Sequence=VSP_038217;
CC   -!- SIMILARITY: Belongs to the PLEKHD1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z92832; CAV31773.1; -; Genomic_DNA.
DR   EMBL; Z92832; CAV31774.1; -; Genomic_DNA.
DR   PIR; T21596; T21596.
DR   RefSeq; NP_001256959.1; NM_001270030.1. [O45420-1]
DR   RefSeq; NP_001256960.1; NM_001270031.1. [O45420-2]
DR   AlphaFoldDB; O45420; -.
DR   SMR; O45420; -.
DR   EPD; O45420; -.
DR   PaxDb; O45420; -.
DR   PeptideAtlas; O45420; -.
DR   EnsemblMetazoa; F31D4.5a.1; F31D4.5a.1; WBGene00009292. [O45420-1]
DR   EnsemblMetazoa; F31D4.5b.1; F31D4.5b.1; WBGene00009292. [O45420-2]
DR   GeneID; 180373; -.
DR   KEGG; cel:CELE_F31D4.5; -.
DR   UCSC; F31D4.5; c. elegans. [O45420-1]
DR   CTD; 180373; -.
DR   WormBase; F31D4.5a; CE43424; WBGene00009292; -. [O45420-1]
DR   WormBase; F31D4.5b; CE43425; WBGene00009292; -. [O45420-2]
DR   eggNOG; ENOG502QTF5; Eukaryota.
DR   GeneTree; ENSGT00950000183017; -.
DR   HOGENOM; CLU_035364_0_0_1; -.
DR   InParanoid; O45420; -.
DR   OMA; KTNCILA; -.
DR   OrthoDB; 1334476at2759; -.
DR   PhylomeDB; O45420; -.
DR   PRO; PR:O45420; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00009292; Expressed in embryo and 3 other tissues.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Coiled coil; Reference proteome.
FT   CHAIN           1..570
FT                   /note="Pleckstrin homology domain-containing family D
FT                   member 1"
FT                   /id="PRO_0000349198"
FT   DOMAIN          83..192
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          542..570
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          202..448
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        7..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         489..539
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_038217"
SQ   SEQUENCE   570 AA;  66400 MW;  D8A22F52F4A0D24D CRC64;
     MTTKTTPKEL KAKKESKKKG SAPEPPKNGP PRTSPPNTIE KKGILRSLSF QFSNLTRKKG
     NDYDLTPEEE GDGYGDEMGP VLGVQNYGIL MKKYKRKNRS ARWAKRFFVL KECFLIYYST
     SYKKVFEKTR RIDLHPKGII PLIGCSIVSG GDVDKKNCLL IAHPQLPSAI IVAASDHQTQ
     EMWLKALRSA TKISYKNTVV GETMIRELEN RGVLLNEEKK SYEERLEAEA KARKEEHDRA
     DELAKDKEEL EAEREKLIRT TKKLKDDLQN VKNELKMTNE MKKTLEQEKM SLNSKTEHLQ
     ANMESLNIEK EKIHEQLQEI VREREKVLID NQNLSTDKCQ LNNRLMEIET SRNCIMTEKE
     KIENLLKMNE QKTQDLEKER QYYTMKTSEL MDHLKEVSEQ RDLTESELKE QMMARLGAEK
     QLQAAEKALE HLEMALKMTG AQMTELQEHI MPDVHKLREF FEQCAEESRF EANRTGIMRN
     AVYARKSIFD VAFSELDGHS LDVFEKFCEY NSQVLPVREK PQKLHKTWKQ SSFKRIGSIR
     RSKRGIRSSF RKKTDSITTQ PREKEPLMQL