ID   PLHD1_HUMAN             Reviewed;         506 AA.
AC   A6NEE1; B9EJC2;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-FEB-2012, sequence version 3.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Pleckstrin homology domain-containing family D member 1;
DE            Short=PH domain-containing family D member 1;
GN   Name=PLEKHD1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA   Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA   Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA   Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA   Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA   Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA   Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA   Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA   Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA   Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA   Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA   Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA   Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA   Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the PLEKHD1 family. {ECO:0000305}.
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DR   EMBL; AL133445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL157996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471061; EAW80997.1; -; Genomic_DNA.
DR   EMBL; BC146872; AAI46873.1; -; mRNA.
DR   CCDS; CCDS53903.1; -.
DR   RefSeq; NP_001154970.1; NM_001161498.1.
DR   AlphaFoldDB; A6NEE1; -.
DR   SMR; A6NEE1; -.
DR   BioGRID; 134555; 2.
DR   IntAct; A6NEE1; 2.
DR   STRING; 9606.ENSP00000317175; -.
DR   iPTMnet; A6NEE1; -.
DR   PhosphoSitePlus; A6NEE1; -.
DR   BioMuta; PLEKHD1; -.
DR   jPOST; A6NEE1; -.
DR   MassIVE; A6NEE1; -.
DR   PaxDb; A6NEE1; -.
DR   PeptideAtlas; A6NEE1; -.
DR   PRIDE; A6NEE1; -.
DR   ProteomicsDB; 979; -.
DR   Antibodypedia; 55088; 10 antibodies from 6 providers.
DR   DNASU; 400224; -.
DR   Ensembl; ENST00000322564.9; ENSP00000317175.7; ENSG00000175985.10.
DR   GeneID; 400224; -.
DR   KEGG; hsa:400224; -.
DR   MANE-Select; ENST00000322564.9; ENSP00000317175.7; NM_001161498.2; NP_001154970.1.
DR   UCSC; uc010ttf.2; human.
DR   CTD; 400224; -.
DR   DisGeNET; 400224; -.
DR   GeneCards; PLEKHD1; -.
DR   HGNC; HGNC:20148; PLEKHD1.
DR   HPA; ENSG00000175985; Tissue enhanced (brain, parathyroid gland, retina).
DR   neXtProt; NX_A6NEE1; -.
DR   OpenTargets; ENSG00000175985; -.
DR   VEuPathDB; HostDB:ENSG00000175985; -.
DR   eggNOG; ENOG502QTF5; Eukaryota.
DR   GeneTree; ENSGT00950000183017; -.
DR   HOGENOM; CLU_035364_0_0_1; -.
DR   InParanoid; A6NEE1; -.
DR   OMA; ANEDMGM; -.
DR   OrthoDB; 1334476at2759; -.
DR   PhylomeDB; A6NEE1; -.
DR   TreeFam; TF320494; -.
DR   PathwayCommons; A6NEE1; -.
DR   SignaLink; A6NEE1; -.
DR   BioGRID-ORCS; 400224; 15 hits in 1063 CRISPR screens.
DR   ChiTaRS; PLEKHD1; human.
DR   GenomeRNAi; 400224; -.
DR   Pharos; A6NEE1; Tdark.
DR   PRO; PR:A6NEE1; -.
DR   Proteomes; UP000005640; Chromosome 14.
DR   RNAct; A6NEE1; protein.
DR   Bgee; ENSG00000175985; Expressed in right hemisphere of cerebellum and 60 other tissues.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Methylation; Reference proteome.
FT   CHAIN           1..506
FT                   /note="Pleckstrin homology domain-containing family D
FT                   member 1"
FT                   /id="PRO_0000349196"
FT   DOMAIN          28..136
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   COILED          146..391
FT                   /evidence="ECO:0000255"
FT   MOD_RES         503
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:B2RPU2"
SQ   SEQUENCE   506 AA;  59203 MW;  F97AAE61E8840FC2 CRC64;
     MFTSKSNSVS PSPSLEQADS DALDISTKVQ LYGVLWKRPF GRPSAKWSRR FFIIKESFLL
     YYSESEKKSF ETNKYFNIHP KGVIPLGGCL VEPKEEPSMP YAMKISHQDF HGNILLAAES
     EFEQTQWLEM LQESGKVTWK NAQLGEAMIK SLEAQGLQLA KEKQEYLDKL MEETEELCLQ
     REQREELERL NQVLEAEKQQ FEEVVQELRM EQEQIKRELE LTARCLKGVE QEKKELRHLT
     ESLQQTLEEL SIEKKKTLEM LEENENHLQT LANQSEQPPP SGGLHSNLRQ IEEKMQQLLE
     EKLLAEKRMK ENEERSRALE EEREFYSSQS QALQNSLQEL TAEKQQAERE LKAEVKVRMD
     LERRLREAEG ALRSLEQGLN SKVRNKEKEE RMRADVSHLK RFFEECIRNA ELEAKMPVIM
     KNSVYIHKAA TRRIKSCRFH RRRSSTSWND MKPSQSFMTS QLDANNMEEL KEVAKRLSRD
     QRFRESIYHI MATQPGAPSA LSRGGK