ID   PLHD1_MOUSE             Reviewed;         505 AA.
AC   B2RPU2;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Pleckstrin homology domain-containing family D member 1;
DE            Short=PH domain-containing family D member 1;
GN   Name=Plekhd1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   METHYLATION [LARGE SCALE ANALYSIS] AT ARG-502, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA   Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA   Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA   Bedford M.T., Comb M.J.;
RT   "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT   methylation.";
RL   Mol. Cell. Proteomics 13:372-387(2014).
CC   -!- SIMILARITY: Belongs to the PLEKHD1 family. {ECO:0000305}.
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DR   EMBL; AC134537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC137602; AAI37603.1; -; mRNA.
DR   CCDS; CCDS49100.1; -.
DR   RefSeq; NP_001170974.1; NM_001177503.1.
DR   AlphaFoldDB; B2RPU2; -.
DR   SMR; B2RPU2; -.
DR   STRING; 10090.ENSMUSP00000119711; -.
DR   iPTMnet; B2RPU2; -.
DR   PhosphoSitePlus; B2RPU2; -.
DR   jPOST; B2RPU2; -.
DR   MaxQB; B2RPU2; -.
DR   PaxDb; B2RPU2; -.
DR   PeptideAtlas; B2RPU2; -.
DR   PRIDE; B2RPU2; -.
DR   ProteomicsDB; 289544; -.
DR   Antibodypedia; 55088; 10 antibodies from 6 providers.
DR   Ensembl; ENSMUST00000140770; ENSMUSP00000119711; ENSMUSG00000066438.
DR   GeneID; 217682; -.
DR   KEGG; mmu:217682; -.
DR   UCSC; uc007obf.2; mouse.
DR   CTD; 400224; -.
DR   MGI; MGI:3036228; Plekhd1.
DR   VEuPathDB; HostDB:ENSMUSG00000066438; -.
DR   eggNOG; ENOG502QTF5; Eukaryota.
DR   GeneTree; ENSGT00950000183017; -.
DR   HOGENOM; CLU_035364_0_0_1; -.
DR   InParanoid; B2RPU2; -.
DR   OMA; ANEDMGM; -.
DR   OrthoDB; 1334476at2759; -.
DR   PhylomeDB; B2RPU2; -.
DR   TreeFam; TF320494; -.
DR   BioGRID-ORCS; 217682; 0 hits in 72 CRISPR screens.
DR   PRO; PR:B2RPU2; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; B2RPU2; protein.
DR   Bgee; ENSMUSG00000066438; Expressed in facial nucleus and 87 other tissues.
DR   Genevisible; B2RPU2; MM.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Methylation; Reference proteome.
FT   CHAIN           1..505
FT                   /note="Pleckstrin homology domain-containing family D
FT                   member 1"
FT                   /id="PRO_0000415810"
FT   DOMAIN          28..136
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          264..284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          146..391
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        266..284
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         502
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0007744|PubMed:24129315"
SQ   SEQUENCE   505 AA;  59097 MW;  238107911CA0D6AC CRC64;
     MFTSKSNSVS PSPSLEQADA DALDISTKVQ LYGVLWKRPF GRSSAKWSRR FFIIKESFLL
     YYSESERKSF ETNKYFNIHP KGVIPLGGCL VEAREEPSMP YAMKISHQDF HGNVLLAAES
     EFEQTQWLEM LQESGKVTWK NAQLGEAMIK SLEAQGLQLA KEKQEYLDKL MEETEELCLQ
     REQREELERL NQVLEAEKQQ FEEVVQELRV EQEQIKRELE LTARCLKGVE QEKKELRHLT
     ESLQHTLEEL SIEKKKTLEM LEEDKNQPQP LTNQSEQPPA SDGLHSNLRQ IEERMQELLA
     EKLLAEKRMK ENEERSRALE EEREFYSSQS QALQNSLQEL TAEKQQAERE LKAEVKVRMD
     LERRLREAEA ALRSLEQGLN SKVRNKEKEE RMRADVSHLK RFFEECIRNA ELEAKMPVIM
     KNSVYIHKAA TRRIKSCRFH RRRSSTSWND MKPSQSFMTS QLEANNIEEL KEVAKRLSRD
     QRFRESIYHI MATQPGASAL PRGGK