ID   PLIGB_GLOBS             Reviewed;         200 AA.
AC   P82143; Q9I850;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2002, sequence version 2.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Phospholipase A2 inhibitor gamma subunit B;
DE            Short=gamma-PLI B {ECO:0000303|PubMed:10791922};
DE   AltName: Full=PLI-gamma {ECO:0000303|PubMed:9230137};
DE   AltName: Full=Phospholipase A2 inhibitor gamma 20 kDa subunit {ECO:0000303|PubMed:10791922};
DE   Flags: Precursor;
OS   Gloydius brevicaudus siniticus (Chinese mamushi) (Agkistrodon blomhoffii
OS   siniticus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Gloydius.
OX   NCBI_TaxID=31147;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=10791922; DOI=10.1080/713803475;
RA   Okumura K., Inoue S., Ohkura N., Ikeda K., Hayashi K.;
RT   "cDNA cloning of the two subunits of a phospholipase A2 inhibitor PLIgamma
RT   from blood plasma of the Chinese mamushi, Agkistrodon blomhoffii
RT   siniticus.";
RL   IUBMB Life 48:99-104(1999).
RN   [2]
RP   PROTEIN SEQUENCE OF 20-49, AND SUBCELLULAR LOCATION.
RC   TISSUE=Plasma;
RX   PubMed=9230137; DOI=10.1042/bj3250527;
RA   Ohkura N., Okuhara H., Inoue S., Ikeda K., Hayashi K.;
RT   "Purification and characterization of three distinct types of phospholipase
RT   A2 inhibitors from the blood plasma of the Chinese mamushi, Agkistrodon
RT   blomhoffii siniticus.";
RL   Biochem. J. 325:527-531(1997).
CC   -!- FUNCTION: Inhibits the enzymatic activity of phospholipase A2 (PA2).
CC   -!- SUBUNIT: Heterodimer of subunit A and subunit B.
CC       {ECO:0000250|UniProtKB:Q9PWI3}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9230137}.
CC       Note=Secreted in blood plasma. {ECO:0000269|PubMed:9230137}.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver.
CC       {ECO:0000305|PubMed:10791922}.
CC   -!- SIMILARITY: Belongs to the CNF-like-inhibitor family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB018373; BAA86971.1; -; mRNA.
DR   AlphaFoldDB; P82143; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019834; F:phospholipase A2 inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0032429; P:regulation of phospholipase A2 activity; IEA:InterPro.
DR   Gene3D; 2.10.60.10; -; 2.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   InterPro; IPR016338; PLipase_A2-inh_a/b-type.
DR   InterPro; IPR004126; PLipase_A2_inh.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   Pfam; PF02988; PLA2_inh; 1.
DR   Pfam; PF00021; UPAR_LY6; 1.
DR   PIRSF; PIRSF002023; PLA2_inhib_alpha/gamma; 1.
DR   SUPFAM; SSF57302; SSF57302; 2.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Phospholipase A2 inhibitor; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:9230137"
FT   CHAIN           20..200
FT                   /note="Phospholipase A2 inhibitor gamma subunit B"
FT                   /evidence="ECO:0000305|PubMed:9230137"
FT                   /id="PRO_0000022998"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        22..46
FT                   /evidence="ECO:0000250|UniProtKB:Q7LZI2"
FT   DISULFID        25..32
FT                   /evidence="ECO:0000250|UniProtKB:Q7LZI2"
FT   DISULFID        39..67
FT                   /evidence="ECO:0000250|UniProtKB:Q7LZI2"
FT   DISULFID        73..94
FT                   /evidence="ECO:0000250|UniProtKB:Q7LZI2"
FT   DISULFID        95..100
FT                   /evidence="ECO:0000250|UniProtKB:Q7LZI2"
FT   DISULFID        120..145
FT                   /evidence="ECO:0000250|UniProtKB:Q7LZI2"
FT   DISULFID        138..165
FT                   /evidence="ECO:0000250|UniProtKB:Q7LZI2"
FT   DISULFID        171..191
FT                   /evidence="ECO:0000250|UniProtKB:Q7LZI2"
SQ   SEQUENCE   200 AA;  22232 MW;  E3FD7DDE33E7C7D7 CRC64;
     MKSFLFCCLL GTFLAIGMCL ECEVCMQPGK RCNGSMMTCK DNEDTCVMFQ TEVIRAPLSF
     TFTSKMCSTS DTCHLDYVET NLPYELAVRS RRACCVGDEC KTMPPVVLEH HDNRYNGLHC
     PGCIGFGSHE CNEKLVSCRD TENQCLSLIG KNFDFVADDI TIKGCATESL CSLLQKKIFS
     AIGEFDLDVK CTPVFPQSSQ