ID   PLIGB_LATSE             Reviewed;         181 AA.
AC   P0DUK6;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   02-JUN-2021, sequence version 1.
DT   25-MAY-2022, entry version 4.
DE   RecName: Full=Phospholipase A2 inhibitor gamma subunit B {ECO:0000305};
DE   AltName: Full=LsPLI-gamma B {ECO:0000303|PubMed:9990137};
DE            Short=PLI-gamma B;
DE   AltName: Full=gamma-PLI B {ECO:0000303|PubMed:9990137};
OS   Laticauda semifasciata (Black-banded sea krait) (Pseudolaticauda
OS   semifasciata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Laticaudinae; Laticauda.
OX   NCBI_TaxID=8631;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND SUBUNIT.
RC   TISSUE=Plasma;
RX   PubMed=9990137; DOI=10.1093/oxfordjournals.jbchem.a022297;
RA   Ohkura N., Kitahara Y., Inoue S., Ikeda K., Hayashi K.;
RT   "Isolation and amino acid sequence of a phospholipase A2 inhibitor from the
RT   blood plasma of the sea krait, Laticauda semifasciata.";
RL   J. Biochem. 125:375-382(1999).
CC   -!- FUNCTION: Strongly inhibits its own venom PLA2 and all other PLA2s
CC       tested including Elapid, Crotalid and Viperid venom PLA2s, as well as
CC       honeybee PLA2s. {ECO:0000269|PubMed:9990137}.
CC   -!- SUBUNIT: Heterotrimer of 2 subunits A and 1 subunit B.
CC       {ECO:0000269|PubMed:9990137}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9990137}.
CC       Note=Secreted in blood plasma. {ECO:0000269|PubMed:9990137}.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver.
CC       {ECO:0000305|PubMed:9990137}.
CC   -!- SIMILARITY: Belongs to the CNF-like-inhibitor family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; P0DUK6; -.
DR   SMR; P0DUK6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019834; F:phospholipase A2 inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.60.10; -; 2.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   InterPro; IPR004126; PLipase_A2_inh.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   Pfam; PF02988; PLA2_inh; 1.
DR   Pfam; PF00021; UPAR_LY6; 1.
DR   SUPFAM; SSF57302; SSF57302; 2.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Phospholipase A2 inhibitor;
KW   Secreted.
FT   CHAIN           1..181
FT                   /note="Phospholipase A2 inhibitor gamma subunit B"
FT                   /evidence="ECO:0000269|PubMed:9990137"
FT                   /id="PRO_0000452704"
FT   DISULFID        3..27
FT                   /evidence="ECO:0000250|UniProtKB:Q7LZI1"
FT   DISULFID        6..13
FT                   /evidence="ECO:0000250|UniProtKB:Q7LZI1"
FT   DISULFID        20..48
FT                   /evidence="ECO:0000250|UniProtKB:Q7LZI1"
FT   DISULFID        54..75
FT                   /evidence="ECO:0000250|UniProtKB:Q7LZI1"
FT   DISULFID        76..81
FT                   /evidence="ECO:0000250|UniProtKB:Q7LZI1"
FT   DISULFID        101..126
FT                   /evidence="ECO:0000250|UniProtKB:Q7LZI1"
FT   DISULFID        119..146
FT                   /evidence="ECO:0000250|UniProtKB:Q7LZI1"
FT   DISULFID        152..172
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   181 AA;  19940 MW;  A7879EE24C3C44FC CRC64;
     LECEICTAPG LECNSWTKTC DANQDTCVTF QTEVIKAPVS FTFISKSCGT SDTCALNYVQ
     TSPHNKLTHK SQRTCCTGEE CKTLPPPVLE HKVNQPDGLQ CPGCFGLSTK DCTEHLVSCR
     GPENQCLSIT GKEFGFIFRA LSYKGCATES LCSLFEKRFW NVLEDVEVDF KCTPALPKSS
     Q