ID   PLIGB_NAJKA             Reviewed;         188 AA.
AC   Q7LZI1;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Phospholipase A2 inhibitor 31 kDa subunit;
DE   AltName: Full=gamma-PLI;
OS   Naja kaouthia (Monocled cobra) (Naja siamensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX   NCBI_TaxID=8649;
RN   [1]
RP   PROTEIN SEQUENCE, DISULFIDE BONDS, GLYCOSYLATION AT ASN-157, SUBCELLULAR
RP   LOCATION, AND SUBUNIT.
RC   TISSUE=Plasma;
RX   PubMed=7980598; DOI=10.1006/bbrc.1994.2592;
RA   Ohkura N., Inoue S., Ikeda K., Hayashi K.;
RT   "The two subunits of a phospholipase A2 inhibitor from the plasma of
RT   thailand cobra having structural similarity to urokinase-type plasminogen
RT   activator receptor and Ly-6 related proteins.";
RL   Biochem. Biophys. Res. Commun. 204:1212-1218(1994).
CC   -!- FUNCTION: Inhibits the enzymatic activity of phospholipase A2.
CC   -!- SUBUNIT: Heterodimer with phospholipase A2 inhibitor 25 kDa.
CC       {ECO:0000269|PubMed:7980598}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7980598}.
CC       Note=Secreted in blood plasma. {ECO:0000269|PubMed:7980598}.
CC   -!- TISSUE SPECIFICITY: Expressed by the liver. {ECO:0000305}.
CC   -!- PTM: N-glycosylated. {ECO:0000269|PubMed:7980598}.
CC   -!- SIMILARITY: Belongs to the CNF-like-inhibitor family. {ECO:0000305}.
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DR   PIR; JC2393; JC2393.
DR   AlphaFoldDB; Q7LZI1; -.
DR   SMR; Q7LZI1; -.
DR   iPTMnet; Q7LZI1; -.
DR   PRIDE; Q7LZI1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019834; F:phospholipase A2 inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0032429; P:regulation of phospholipase A2 activity; IEA:InterPro.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   InterPro; IPR016338; PLipase_A2-inh_a/b-type.
DR   InterPro; IPR004126; PLipase_A2_inh.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   Pfam; PF02988; PLA2_inh; 1.
DR   PIRSF; PIRSF002023; PLA2_inhib_alpha/gamma; 1.
DR   SMART; SM00134; LU; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Phospholipase A2 inhibitor; Secreted.
FT   CHAIN           1..188
FT                   /note="Phospholipase A2 inhibitor 31 kDa subunit"
FT                   /evidence="ECO:0000269|PubMed:7980598"
FT                   /id="PRO_0000215266"
FT   CARBOHYD        157
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:7980598"
FT   DISULFID        3..27
FT                   /evidence="ECO:0000269|PubMed:7980598"
FT   DISULFID        6..13
FT                   /evidence="ECO:0000269|PubMed:7980598"
FT   DISULFID        20..48
FT                   /evidence="ECO:0000269|PubMed:7980598"
FT   DISULFID        54..75
FT                   /evidence="ECO:0000269|PubMed:7980598"
FT   DISULFID        76..81
FT                   /evidence="ECO:0000269|PubMed:7980598"
FT   DISULFID        99..124
FT                   /evidence="ECO:0000269|PubMed:7980598"
FT   DISULFID        117..146
FT                   /evidence="ECO:0000269|PubMed:7980598"
FT   DISULFID        150..172
FT                   /evidence="ECO:0000269|PubMed:7980598"
SQ   SEQUENCE   188 AA;  20452 MW;  5E2A6CE57FFDA6D9 CRC64;
     HSCEICHNVG KSCEGSVEPC TSPEDQCGTV VLEFSPAPVS FRSIHKNCFS SSLCKLGSFD
     VNVGQNTYVR GRIQCCDEER CEEPQFSGHC ASHPNGYYCP GIFGLFSLDS SANEAVCKGT
     ETKCINIAGY RKEMYPGDIA YNIKGCISSC PELSLSNRTH EVDRNELIKV ECTDAVKIPP
     SECQSSGI