PLIG_ECOLI
ID PLIG_ECOLI Reviewed; 133 AA.
AC P76002;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Inhibitor of g-type lysozyme;
DE Flags: Precursor;
GN Name=pliG; Synonyms=ycgK; OrderedLocusNames=b1178, JW1167;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=20734102; DOI=10.1007/s00018-010-0507-3;
RA Vanderkelen L., Van Herreweghe J.M., Vanoirbeek K.G., Baggerman G.,
RA Myrnes B., Declerck P.J., Nilsen I.W., Michiels C.W., Callewaert L.;
RT "Identification of a bacterial inhibitor against g-type lysozyme.";
RL Cell. Mol. Life Sci. 68:1053-1064(2011).
CC -!- FUNCTION: Inhibits activity of g-type lysozyme, which confers increased
CC lysozyme tolerance to the bacterium. {ECO:0000269|PubMed:20734102}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:20734102}.
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DR EMBL; U00096; AAC74262.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA36012.1; -; Genomic_DNA.
DR PIR; G64863; G64863.
DR RefSeq; NP_415696.1; NC_000913.3.
DR RefSeq; WP_000695215.1; NZ_SSZK01000010.1.
DR PDB; 4DXZ; X-ray; 1.25 A; A=23-133.
DR PDB; 4DY3; X-ray; 1.80 A; A/B=23-133.
DR PDB; 4G9S; X-ray; 0.95 A; B=23-133.
DR PDBsum; 4DXZ; -.
DR PDBsum; 4DY3; -.
DR PDBsum; 4G9S; -.
DR AlphaFoldDB; P76002; -.
DR SMR; P76002; -.
DR BioGRID; 4260099; 13.
DR IntAct; P76002; 1.
DR STRING; 511145.b1178; -.
DR SWISS-2DPAGE; P76002; -.
DR jPOST; P76002; -.
DR PaxDb; P76002; -.
DR PRIDE; P76002; -.
DR EnsemblBacteria; AAC74262; AAC74262; b1178.
DR EnsemblBacteria; BAA36012; BAA36012; BAA36012.
DR GeneID; 946963; -.
DR KEGG; ecj:JW1167; -.
DR KEGG; eco:b1178; -.
DR PATRIC; fig|511145.12.peg.1222; -.
DR EchoBASE; EB3651; -.
DR eggNOG; ENOG5032ZD3; Bacteria.
DR HOGENOM; CLU_129252_0_0_6; -.
DR OMA; WMSINIK; -.
DR PhylomeDB; P76002; -.
DR BioCyc; EcoCyc:G6615-MON; -.
DR PHI-base; PHI:2648; -.
DR PRO; PR:P76002; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR GO; GO:0042597; C:periplasmic space; IDA:EcoCyc.
DR GO; GO:0060241; F:lysozyme inhibitor activity; IDA:EcoCyc.
DR InterPro; IPR007280; Peptidase_C_arc/bac.
DR Pfam; PF04151; PPC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Periplasm; Reference proteome; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..133
FT /note="Inhibitor of g-type lysozyme"
FT /id="PRO_0000013828"
FT STRAND 26..28
FT /evidence="ECO:0007829|PDB:4G9S"
FT STRAND 36..45
FT /evidence="ECO:0007829|PDB:4G9S"
FT STRAND 50..56
FT /evidence="ECO:0007829|PDB:4G9S"
FT STRAND 61..67
FT /evidence="ECO:0007829|PDB:4G9S"
FT STRAND 72..76
FT /evidence="ECO:0007829|PDB:4G9S"
FT STRAND 102..112
FT /evidence="ECO:0007829|PDB:4G9S"
FT HELIX 115..119
FT /evidence="ECO:0007829|PDB:4G9S"
FT STRAND 123..133
FT /evidence="ECO:0007829|PDB:4G9S"
SQ SEQUENCE 133 AA; 14906 MW; 54997548219541F1 CRC64;
MKIKSIRKAV LLLALLTSTS FAAGKNVNVE FRKGHSSAQY SGEIKGYDYD TYTFYAKKGQ
KVHVSISNEG ADTYLFGPGI DDSVDLSRYS PELDSHGQYS LPASGKYELR VLQTRNDARK
NKTKKYNVDI QIK
