ID   PLLP_BOVIN              Reviewed;         182 AA.
AC   A6H7B0;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Plasmolipin;
DE   AltName: Full=Plasma membrane proteolipid;
GN   Name=PLLP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Appears to be involved in myelination. Could also participate
CC       in ion transport events as addition of plasmolipin to lipid bilayers
CC       induces the formation of ion channels, which are voltage-dependent and
CC       K(+)-selective (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Hexamer arranged as a trimer of two plasmolipin subunits.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the MAL family. {ECO:0000305}.
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DR   EMBL; BC146177; AAI46178.1; -; mRNA.
DR   RefSeq; NP_001092593.1; NM_001099123.1.
DR   AlphaFoldDB; A6H7B0; -.
DR   STRING; 9913.ENSBTAP00000032317; -.
DR   Ensembl; ENSBTAT00000056565; ENSBTAP00000049090; ENSBTAG00000011700.
DR   GeneID; 613446; -.
DR   KEGG; bta:613446; -.
DR   CTD; 51090; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011700; -.
DR   VGNC; VGNC:33037; PLLP.
DR   GeneTree; ENSGT00940000156011; -.
DR   InParanoid; A6H7B0; -.
DR   OMA; WFNTVAM; -.
DR   OrthoDB; 1455336at2759; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000011700; Expressed in midbrain and 92 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0019911; F:structural constituent of myelin sheath; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0042552; P:myelination; IBA:GO_Central.
DR   InterPro; IPR013295; MAL.
DR   InterPro; IPR008253; Marvel.
DR   Pfam; PF01284; MARVEL; 1.
DR   PRINTS; PR01884; MALPROTEIN.
DR   PROSITE; PS51225; MARVEL; 1.
PE   2: Evidence at transcript level;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..182
FT                   /note="Plasmolipin"
FT                   /id="PRO_0000332210"
FT   TOPO_DOM        1..35
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        57..68
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..99
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..141
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..182
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          32..166
FT                   /note="MARVEL"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   182 AA;  19778 MW;  67CDF52E501FFEA2 CRC64;
     MAEFPSKVNT RTSSPAQGGG AVVSTLSPDL GFVRSSLGAL MLLQLVLGLL VWALIADTPY
     HLYPSYGWVM FVAVFLWLVT IIFFVLYLFQ LHMKLYMVPW PLVLMVFNVG ATVLYITAFI
     TCSASVELTS LKGSQPYNQR AAASFFSCLV MIAYGVSAFL SFQAWRGVGS NAATSQMAGG
     YA