PLLP_MOUSE
ID PLLP_MOUSE Reviewed; 182 AA.
AC Q9DCU2; Q544Q5;
DT 15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Plasmolipin;
DE AltName: Full=Plasma membrane proteolipid;
GN Name=Pllp; Synonyms=Plapi, Pmlp, Tm4sf11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvEvTacfBr; TISSUE=Spleen;
RX PubMed=11707781; DOI=10.1007/s00335-001-3035-5;
RA Hamacher M., Pippirs U., Koehler A., Mueller H.W., Bosse F.;
RT "Plasmolipin: genomic structure, chromosomal localization, protein
RT expression pattern and putative association with Bardet-Biedl syndrome.";
RL Mamm. Genome 12:933-937(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney, and Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Appears to be involved in myelination. Could also participate
CC in ion transport events as addition of plasmolipin to lipid bilayers
CC induces the formation of ion channels, which are voltage-dependent and
CC K(+)-selective (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Hexamer arranged as a trimer of two plasmolipin subunits.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the MAL family. {ECO:0000305}.
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DR EMBL; AJ298129; CAC88126.1; -; Genomic_DNA.
DR EMBL; AJ298130; CAC88126.1; JOINED; Genomic_DNA.
DR EMBL; AK002477; BAB22130.1; -; mRNA.
DR EMBL; AK032540; BAC27916.1; -; mRNA.
DR EMBL; BC024534; AAH24534.1; -; mRNA.
DR CCDS; CCDS22546.1; -.
DR RefSeq; NP_080661.1; NM_026385.4.
DR AlphaFoldDB; Q9DCU2; -.
DR BioGRID; 212450; 1.
DR STRING; 10090.ENSMUSP00000034227; -.
DR iPTMnet; Q9DCU2; -.
DR PhosphoSitePlus; Q9DCU2; -.
DR jPOST; Q9DCU2; -.
DR MaxQB; Q9DCU2; -.
DR PaxDb; Q9DCU2; -.
DR PeptideAtlas; Q9DCU2; -.
DR PRIDE; Q9DCU2; -.
DR ProteomicsDB; 289446; -.
DR Antibodypedia; 44063; 105 antibodies from 20 providers.
DR DNASU; 67801; -.
DR Ensembl; ENSMUST00000034227; ENSMUSP00000034227; ENSMUSG00000031775.
DR GeneID; 67801; -.
DR KEGG; mmu:67801; -.
DR UCSC; uc009mwv.1; mouse.
DR CTD; 51090; -.
DR MGI; MGI:1915051; Pllp.
DR VEuPathDB; HostDB:ENSMUSG00000031775; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000156011; -.
DR HOGENOM; CLU_103581_2_0_1; -.
DR InParanoid; Q9DCU2; -.
DR OMA; WFNTVAM; -.
DR OrthoDB; 1455336at2759; -.
DR PhylomeDB; Q9DCU2; -.
DR TreeFam; TF316174; -.
DR BioGRID-ORCS; 67801; 1 hit in 74 CRISPR screens.
DR PRO; PR:Q9DCU2; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9DCU2; protein.
DR Bgee; ENSMUSG00000031775; Expressed in epithelium of stomach and 145 other tissues.
DR ExpressionAtlas; Q9DCU2; baseline and differential.
DR Genevisible; Q9DCU2; MM.
DR GO; GO:0043218; C:compact myelin; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0045121; C:membrane raft; ISO:MGI.
DR GO; GO:0019911; F:structural constituent of myelin sheath; IBA:GO_Central.
DR GO; GO:0006811; P:ion transport; ISO:MGI.
DR GO; GO:0042552; P:myelination; IBA:GO_Central.
DR GO; GO:0009611; P:response to wounding; IEA:Ensembl.
DR InterPro; IPR013295; MAL.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR01884; MALPROTEIN.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Ion channel; Ion transport; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..182
FT /note="Plasmolipin"
FT /id="PRO_0000156814"
FT TOPO_DOM 1..35
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..68
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..99
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..141
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..182
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 32..166
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9Y342"
SQ SEQUENCE 182 AA; 19801 MW; F2D78E5E22173B42 CRC64;
MAEFPSKVST RTSSPAQGVG ASVSALRPDL GFVRSALGVL ALLQLALGLL VWALIADTPY
HLYPAYGWVM FVAVFLWLVT IVFFIIYLFQ LHMKLYMVPW PLVLLIFFVA ATVLYITAFI
ACAAAVDLTS LRGSRPYNQR SAASFFACLV MIAYGVSAFF SFQAWRGVGS NAATSQMAGG
YS
