PLLP_RAT
ID PLLP_RAT Reviewed; 182 AA.
AC P47987;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Plasmolipin;
DE AltName: Full=Plasma membrane proteolipid;
GN Name=Pllp; Synonyms=Pmlp, Tm4sf11;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
RC STRAIN=Sprague-Dawley; TISSUE=Kidney;
RX PubMed=7929173; DOI=10.1016/s0021-9258(17)31477-1;
RA Fischer I., Sapirstein V.S.;
RT "Molecular cloning of plasmolipin. Characterization of a novel proteolipid
RT restricted to brain and kidney.";
RL J. Biol. Chem. 269:24912-24919(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RC STRAIN=Wistar; TISSUE=Sciatic nerve;
RX PubMed=8714710; DOI=10.1111/j.1460-9568.1996.tb01223.x;
RA Gillen C., Gleichmann M., Greiner-Petter R., Zoidl G., Kupfer S., Bosse F.,
RA Auer J., Mueller H.W.;
RT "Full-lenth cloning, expression and cellular localization of rat
RT plasmolipin mRNA, a proteolipid of PNS and CNS.";
RL Eur. J. Neurosci. 8:405-414(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Appears to be involved in myelination. Could also participate
CC in ion transport events as addition of plasmolipin to lipid bilayers
CC induces the formation of ion channels, which are voltage-dependent and
CC K(+)-selective.
CC -!- SUBUNIT: Hexamer arranged as a trimer of two plasmolipin subunits.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:8714710}; Multi-pass
CC membrane protein {ECO:0000269|PubMed:8714710}.
CC -!- TISSUE SPECIFICITY: Expression restricted to the sciatic nerve, brain
CC and kidney. In the sciatic nerve, found in Schwann cells; in the brain,
CC in developing oligodendrocytes, especially of the corpus callosum, of
CC cortical white matter, in the optic nerve and in the stratum radiatum
CC and stratum oriens of the hippocampus. In kidney, segregated to the
CC apical surface of renal tubular epithelia.
CC -!- DEVELOPMENTAL STAGE: In the sciatic nerve, first detected at postnatal
CC day P4, increases to a maximum at day P14 and then declines to moderate
CC levels in adulthood. In the brain, onset of expression is at day P1,
CC levels increase to reach a maximum at P20 and decline slightly to
CC adulthood.
CC -!- SIMILARITY: Belongs to the MAL family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA62133.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U13617; AAA62133.1; ALT_INIT; mRNA.
DR EMBL; Z49858; CAA90017.1; -; mRNA.
DR EMBL; BC078823; AAH78823.1; -; mRNA.
DR PIR; A55046; A55046.
DR RefSeq; NP_071978.1; NM_022533.1.
DR AlphaFoldDB; P47987; -.
DR BioGRID; 249048; 1.
DR STRING; 10116.ENSRNOP00000022277; -.
DR TCDB; 1.A.64.1.1; the plasmolipin (plasmolipin) family.
DR iPTMnet; P47987; -.
DR PhosphoSitePlus; P47987; -.
DR PaxDb; P47987; -.
DR PRIDE; P47987; -.
DR Ensembl; ENSRNOT00000022277; ENSRNOP00000022277; ENSRNOG00000016558.
DR GeneID; 64364; -.
DR KEGG; rno:64364; -.
DR UCSC; RGD:621478; rat.
DR CTD; 51090; -.
DR RGD; 621478; Pllp.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000156011; -.
DR HOGENOM; CLU_103581_2_0_1; -.
DR InParanoid; P47987; -.
DR OMA; WFNTVAM; -.
DR OrthoDB; 1455336at2759; -.
DR PhylomeDB; P47987; -.
DR TreeFam; TF316174; -.
DR PRO; PR:P47987; -.
DR Proteomes; UP000002494; Chromosome 19.
DR Bgee; ENSRNOG00000016558; Expressed in stomach and 17 other tissues.
DR Genevisible; P47987; RN.
DR GO; GO:0043218; C:compact myelin; IDA:RGD.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0045121; C:membrane raft; IDA:RGD.
DR GO; GO:0019911; F:structural constituent of myelin sheath; IBA:GO_Central.
DR GO; GO:0006811; P:ion transport; IDA:RGD.
DR GO; GO:0042552; P:myelination; IEP:RGD.
DR GO; GO:0009611; P:response to wounding; IEP:RGD.
DR InterPro; IPR013295; MAL.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR01884; MALPROTEIN.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Ion channel; Ion transport; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..182
FT /note="Plasmolipin"
FT /id="PRO_0000156815"
FT TOPO_DOM 1..35
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 57..68
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..99
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..141
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..182
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 32..166
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 182 AA; 19834 MW; 18F5844F9AA79F6E CRC64;
MAEFPSKVST RTSSPAQGVG ASVSAMRPDL GFVRSALGVL ALLQLVLGLL VWALIADTPY
HLYPAYGWVM FVAVFLWLVT IVFFIIYLFQ LHMKLYMVPW PLVLLVFFVA ATVLYITAFV
ACAAAVDLTS LRGSRPYNQR SAASFFACLV MIAYGLSAFF SFQAWRGVGS NAATSQMAGG
YS
