ASTE_DROME
ID ASTE_DROME Reviewed; 854 AA.
AC Q9VPW1; B5RJ71; O61517; Q960G8;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Protein asteroid;
GN Name=ast; ORFNames=CG4426;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-815, FUNCTION, TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RX PubMed=9644838; DOI=10.1139/g98-021;
RA Kotarski M.A., Leonard D.A., Bennett S.A., Bishop C.P., Wahn S.D.,
RA Sedore S.A., Shrader M.;
RT "The Drosophila gene asteroid encodes a novel protein and displays dosage-
RT sensitive interactions with Star and Egfr.";
RL Genome 41:295-302(1998).
CC -!- FUNCTION: May function in EGF receptor signaling. May play a role in
CC compound eye morphogenesis. {ECO:0000269|PubMed:9644838}.
CC -!- TISSUE SPECIFICITY: Expressed in the proliferative tissues of embryos
CC and in the mitotically active tissue anterior to the morphogenetic
CC furrow in eye imaginal disks. {ECO:0000269|PubMed:9644838}.
CC -!- DEVELOPMENTAL STAGE: Expressed at higher levels during the embryonic
CC and pupal stages of development. Expressed in proliferating tissues of
CC the presumptive mesoderm in stage 7 gastrulating embryos. Expressed in
CC the mesectoderm and anterior and posterior midgut primordia of stage 9
CC embryos. Also expressed in proliferating cells of the central nervous
CC system during germ-band retraction. {ECO:0000269|PubMed:9644838}.
CC -!- SIMILARITY: Belongs to the asteroid family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC05483.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE014134; AAF51424.1; -; Genomic_DNA.
DR EMBL; AY052070; AAK93494.1; -; mRNA.
DR EMBL; BT044345; ACH92410.1; -; mRNA.
DR EMBL; AF047010; AAC05483.1; ALT_FRAME; Genomic_DNA.
DR RefSeq; NP_523451.2; NM_078727.3.
DR AlphaFoldDB; Q9VPW1; -.
DR BioGRID; 59535; 6.
DR IntAct; Q9VPW1; 7.
DR STRING; 7227.FBpp0077617; -.
DR PaxDb; Q9VPW1; -.
DR PRIDE; Q9VPW1; -.
DR DNASU; 33282; -.
DR EnsemblMetazoa; FBtr0077952; FBpp0077617; FBgn0015905.
DR GeneID; 33282; -.
DR KEGG; dme:Dmel_CG4426; -.
DR UCSC; CG4426-RA; d. melanogaster.
DR CTD; 33282; -.
DR FlyBase; FBgn0015905; ast.
DR VEuPathDB; VectorBase:FBgn0015905; -.
DR eggNOG; ENOG502QQRA; Eukaryota.
DR GeneTree; ENSGT00390000010145; -.
DR HOGENOM; CLU_017330_0_0_1; -.
DR InParanoid; Q9VPW1; -.
DR OMA; VMRCVFE; -.
DR OrthoDB; 966573at2759; -.
DR PhylomeDB; Q9VPW1; -.
DR BioGRID-ORCS; 33282; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33282; -.
DR PRO; PR:Q9VPW1; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0015905; Expressed in cleaving embryo and 28 other tissues.
DR Genevisible; Q9VPW1; DM.
DR GO; GO:0001745; P:compound eye morphogenesis; IMP:FlyBase.
DR GO; GO:0001752; P:compound eye photoreceptor fate commitment; IMP:UniProtKB.
DR GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
DR GO; GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IMP:FlyBase.
DR GO; GO:0007526; P:larval somatic muscle development; IMP:FlyBase.
DR InterPro; IPR026832; Asteroid.
DR InterPro; IPR039436; Asteroid_dom.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR PANTHER; PTHR15665; PTHR15665; 1.
DR Pfam; PF12813; XPG_I_2; 1.
DR SUPFAM; SSF88723; SSF88723; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Reference proteome.
FT CHAIN 1..854
FT /note="Protein asteroid"
FT /id="PRO_0000310462"
FT REGION 368..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..427
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 263
FT /note="A -> G (in Ref. 5; AAC05483)"
FT /evidence="ECO:0000305"
FT CONFLICT 496
FT /note="C -> G (in Ref. 5; AAC05483)"
FT /evidence="ECO:0000305"
FT CONFLICT 509
FT /note="I -> M (in Ref. 5; AAC05483)"
FT /evidence="ECO:0000305"
FT CONFLICT 534
FT /note="M -> I (in Ref. 5; AAC05483)"
FT /evidence="ECO:0000305"
FT CONFLICT 568
FT /note="E -> V (in Ref. 5; AAC05483)"
FT /evidence="ECO:0000305"
FT CONFLICT 670
FT /note="A -> T (in Ref. 5; AAC05483)"
FT /evidence="ECO:0000305"
FT CONFLICT 798
FT /note="T -> R (in Ref. 3; AAK93494)"
FT /evidence="ECO:0000305"
FT CONFLICT 812
FT /note="R -> C (in Ref. 5; AAC05483)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 854 AA; 98376 MW; 2C51D6616254F0D6 CRC64;
MGVRGLTSYI AQRAEIYLKP HELHSTALVI DGDNLSCNLY KDVTGSYSAF GGDYDDFYRA
VVQFFQVLAE CNIRPYVLMD GGYEERKLRT VSTRLRNKIS VIKKINPNAS ITLFPLHLKE
VFVDAVRDCG VPVMRCVFEA DDELAALARK LNCPVLSYDS DFYIHNVKYI PLITLTVKVL
TKQVKDKNSS NQKDSRDLRH CEAKNVKKRT RANKIVTGIQ TTGLTASTKG SSKTYKYLDC
CIYRVSHLCG RGTLSPEKLP LFAALLGNDY IARSAFKNFF AAGMGKAGRS RKLKLQQKRI
QVILTWLKEE TAESALAKVL SRLKKNQRDS LVSQVNAAIS GYSNELCHAY DYFDEHYENA
FPYIEPVSEE ECSDDEHSSS SDEKFSDVEE GEDQEEADNQ DEEQQEENQD VDSGDEEEEE
ADEGLELEVE DKTLLFPQWF LDKLYPAHLP RSFVDLMHLR KYINNPQIEH FPFHDSNEVA
LPILNYVFAL LHHVECEKIE LPLEVDMDIE GSTVPYLTYL TRALRVTNVR YFKMPIEKKP
AYPFDPLSPD ARHLRAVFED NAPNADTEKL FSKLDQLPED LRLYFLAIIY WLHRSEHCDL
LHLHSLILSL VVLRTIDVTI PAEREVKTFL KRFGKTLKAE RAVRDKEAAE GIKRGIKPAL
LELSVPDRMA HVPKSDCYLT QERLLPHFHM QEIFKKKFDL YSTTVIHAFA EFQAVVYQLN
GLNSLLDFPL LSPRMNQLYC GAFLYNMYDV LRNRADVRYH VENFLLPDSK LMFDFYCYLY
DWCAEFIPTW KRLEVDPTAA KALQKKRLKK QRQAARKVEL REAIADPNAE MVEDADPEND
FFDLNNKFCA LKVA
