ID   PLMN_STRCA              Reviewed;          33 AA.
AC   P83169;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   02-DEC-2020, entry version 48.
DE   RecName: Full=Plasminogen;
DE            EC=3.4.21.7;
DE   Flags: Fragments;
GN   Name=PLG;
OS   Struthio camelus (Common ostrich).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Palaeognathae; Struthioniformes; Struthionidae;
OC   Struthio.
OX   NCBI_TaxID=8801;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, AND CHARACTERIZATION.
RC   TISSUE=Plasma {ECO:0000269|PubMed:11435135};
RX   PubMed=11435135; DOI=10.1016/s1096-4959(01)00396-7;
RA   Thomas A.R., Naude R.J., Oelofsen W., Naganuma T., Muramoto K.;
RT   "Purification and partial characterisation of alpha(2)-antiplasmin and
RT   plasmin(ogen) from ostrich plasma.";
RL   Comp. Biochem. Physiol. 129B:809-820(2001).
CC   -!- FUNCTION: Plasmin dissolves the fibrin of blood clots and acts as a
CC       proteolytic factor in a variety of other processes including embryonic
CC       development, tissue remodeling, tumor invasion, and inflammation; in
CC       ovulation it weakens the walls of the Graafian follicle. It activates
CC       the urokinase-type plasminogen activator, collagenases and several
CC       complement zymogens, such as C1 and C5. It cleaves fibrin, fibronectin,
CC       thrombospondin, laminin and von Willebrand factor (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher
CC         selectivity than trypsin. Converts fibrin into soluble products.;
CC         EC=3.4.21.7; Evidence={ECO:0000250|UniProtKB:P00747};
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Optimum pH is 8.;
CC       Temperature dependence:
CC         Optimum temperature is 40 degrees Celsius.;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MISCELLANEOUS: Plasmin is inactivated by alpha-2-antiplasmin
CC       immediately after dissociation from the clot.
CC       {ECO:0000250|UniProtKB:P00747}.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   GO; GO:0042730; P:fibrinolysis; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; NAS:UniProtKB.
PE   1: Evidence at protein level;
KW   Blood coagulation; Direct protein sequencing; Fibrinolysis; Hemostasis;
KW   Hydrolase; Protease; Secreted; Serine protease; Zymogen.
FT   CHAIN           1..>33
FT                   /note="Plasminogen"
FT                   /id="PRO_0000088705"
FT   NON_CONS        16..17
FT                   /evidence="ECO:0000305"
FT   NON_TER         33
FT                   /evidence="ECO:0000303|PubMed:11435135"
SQ   SEQUENCE   33 AA;  3946 MW;  22BE697EA379E7C2 CRC64;
     NILDGYVRXE GAWLLSRIYL DEVEGRDVVY YRT