ID   PLMS_SQUAC              Reviewed;          30 AA.
AC   P82542; P83008;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Phospholemman-like protein;
DE   AltName: Full=PLMS;
DE   Flags: Fragment;
OS   Squalus acanthias (Spiny dogfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Squalomorphii; Squaliformes; Squalidae; Squalus.
OX   NCBI_TaxID=7797;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Rectal gland;
RX   PubMed=10961995; DOI=10.1074/jbc.m005168200;
RA   Mahmmoud Y.A., Vorum H., Cornelius F.;
RT   "Identification of a phospholemman-like protein from shark rectal glands:
RT   evidence for indirect regulation of Na,K-ATPase by protein kinase C via a
RT   novel member of the FxYDY family.";
RL   J. Biol. Chem. 275:35969-35977(2000).
RN   [2]
RP   SEQUENCE REVISION TO 19; 24 AND 26.
RA   Cornelius F., Mahmmoud Y.A., Cramb G.;
RL   Submitted (DEC-2001) to UniProtKB.
RN   [3]
RP   PROTEIN SEQUENCE OF 1-25.
RC   TISSUE=Rectal gland;
RX   PubMed=11676495; DOI=10.1006/bbrc.2001.5826;
RA   Schuurmans Stekhoven F.M.A.H., Flik G., Wendelaar Bonga S.E.;
RT   "N-terminal sequences of small ion channels in rectal glands of sharks: a
RT   biochemical hallmark for classification and phylogeny?";
RL   Biochem. Biophys. Res. Commun. 288:670-675(2001).
CC   -!- FUNCTION: Induces a hyperpolarization-activated chloride current when
CC       expressed in Xenopus oocytes. May have a functional role in muscle
CC       contraction.
CC   -!- SUBCELLULAR LOCATION: Microsome membrane; Single-pass type I membrane
CC       protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type
CC       I membrane protein {ECO:0000305}.
CC   -!- PTM: Phosphorylated by protein kinase a (PK-A) and protein kinase C
CC       (PK-C). Phosphorylated in response to insulin and adrenergic
CC       stimulation (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FXYD family. {ECO:0000305}.
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DR   AlphaFoldDB; P82542; -.
DR   SMR; P82542; -.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:InterPro.
DR   GO; GO:0043269; P:regulation of ion transport; IEA:InterPro.
DR   InterPro; IPR000272; Ion-transport_regulator_FXYD.
DR   Pfam; PF02038; ATP1G1_PLM_MAT8; 1.
DR   PROSITE; PS01310; FXYD; 1.
PE   1: Evidence at protein level;
KW   Chloride; Chloride channel; Direct protein sequencing;
KW   Endoplasmic reticulum; Ion channel; Ion transport; Membrane; Microsome;
KW   Phosphoprotein; Transmembrane; Transport.
FT   CHAIN           1..>30
FT                   /note="Phospholemman-like protein"
FT                   /id="PRO_0000148183"
FT   NON_TER         30
SQ   SEQUENCE   30 AA;  3430 MW;  647BE1C060B2C9F1 CRC64;
     MDPAGPDNDE RFTYDYYRLR VVGLIVAAVL