ID   PLNA_LACPL              Reviewed;          48 AA.
AC   P80214; F9UU02;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Bacteriocin plantaricin-A;
DE   Flags: Precursor;
GN   Name=plnA; OrderedLocusNames=lp_0415;
OS   Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS   (Lactobacillus plantarum).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactiplantibacillus.
OX   NCBI_TaxID=220668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C11;
RX   PubMed=8117074; DOI=10.1128/aem.60.1.160-166.1994;
RA   Diep B.D., Havarstein L.S., Nissen-Meyer J., Nes F.I.;
RT   "The gene encoding plantaricin A, a bacteriocin from Lactobacillus
RT   plantarum C11, is located on the same transcription unit as an agr-like
RT   regulatory system.";
RL   Appl. Environ. Microbiol. 60:160-166(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C11;
RX   PubMed=8755874; DOI=10.1128/jb.178.15.4472-4483.1996;
RA   Diep D.B., Havarstein L.S., Nes I.F.;
RT   "Characterization of the locus responsible for the bacteriocin production
RT   in Lactobacillus plantarum C11.";
RL   J. Bacteriol. 178:4472-4483(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA   Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA   Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA   Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA   Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA   Siezen R.J.;
RT   "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=22156394; DOI=10.1128/jb.06275-11;
RA   Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA   Kleerebezem M., van Hijum S.A.;
RT   "Complete resequencing and reannotation of the Lactobacillus plantarum
RT   WCFS1 genome.";
RL   J. Bacteriol. 194:195-196(2012).
RN   [5]
RP   PROTEIN SEQUENCE OF 26-47.
RC   STRAIN=C11;
RX   PubMed=8245827; DOI=10.1099/00221287-139-9-1973;
RA   Nissen-Meyer J., Granly Larsen A.G., Sletten K., Daeschel M., Nes I.F.;
RT   "Purification and characterization of plantaricin A, a Lactobacillus
RT   plantarum bacteriocin whose activity depends on the action of two
RT   peptides.";
RL   J. Gen. Microbiol. 139:1973-1978(1993).
CC   -!- FUNCTION: This heat stable bacteriocin inhibits the growth of closely
CC       related Lactobacillus species. It may act as a pore-forming protein,
CC       creating a channel in the cell membrane through a 'barrel stave'
CC       mechanism.
CC   -!- SUBUNIT: Active plantaricin A is composed of an alpha chain and a beta
CC       chain.
CC   -!- MISCELLANEOUS: The beta chain sequence is shown.
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DR   EMBL; X75323; CAA53069.1; -; Genomic_DNA.
DR   EMBL; X94434; CAA64204.1; -; Genomic_DNA.
DR   EMBL; AL935263; CCC77922.1; -; Genomic_DNA.
DR   PIR; A45913; A45913.
DR   RefSeq; WP_003641979.1; NC_004567.2.
DR   RefSeq; YP_004888436.1; NC_004567.2.
DR   PDB; 1YTR; NMR; -; A=23-48.
DR   PDBsum; 1YTR; -.
DR   AlphaFoldDB; P80214; -.
DR   BMRB; P80214; -.
DR   SMR; P80214; -.
DR   STRING; 220668.lp_0415; -.
DR   TCDB; 1.C.22.1.6; the lactococcin a (lactococcin a) family.
DR   EnsemblBacteria; CCC77922; CCC77922; lp_0415.
DR   GeneID; 57024218; -.
DR   KEGG; lpl:lp_0415; -.
DR   eggNOG; ENOG5032N8N; Bacteria.
DR   HOGENOM; CLU_3154236_0_0_9; -.
DR   BioCyc; LPLA220668:G1GW0-344-MON; -.
DR   EvolutionaryTrace; P80214; -.
DR   Proteomes; UP000000432; Chromosome.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR010133; Bacteriocin_signal_seq.
DR   TIGRFAMs; TIGR01847; bacteriocin_sig; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic; Antimicrobial; Bacteriocin;
KW   Direct protein sequencing; Reference proteome.
FT   PROPEP          1..25
FT                   /evidence="ECO:0000269|PubMed:8245827"
FT                   /id="PRO_0000002776"
FT   PEPTIDE         26..48
FT                   /note="Bacteriocin plantaricin-A"
FT                   /id="PRO_0000002777"
FT   VARIANT         26
FT                   /note="Missing (in the alpha chain)"
FT   STRAND          31..33
FT                   /evidence="ECO:0007829|PDB:1YTR"
FT   HELIX           34..43
FT                   /evidence="ECO:0007829|PDB:1YTR"
SQ   SEQUENCE   48 AA;  5458 MW;  6C584810DE50D3F5 CRC64;
     MKIQIKGMKQ LSNKEMQKIV GGKSSAYSLQ MGATAIKQVK KLFKKWGW