PLP2_HUMAN
ID PLP2_HUMAN Reviewed; 152 AA.
AC Q04941; A6NDT7; Q32MM8;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Proteolipid protein 2;
DE AltName: Full=Differentiation-dependent protein A4;
DE AltName: Full=Intestinal membrane A4 protein;
GN Name=PLP2; Synonyms=A4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8470895; DOI=10.1006/abbi.1993.1197;
RA Oliva M.M., Wu T.-C., Yang V.W.;
RT "Isolation and characterization of a differentiation-dependent gene in the
RT human colonic cell line HT29-18.";
RL Arch. Biochem. Biophys. 302:183-192(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9344658; DOI=10.1006/geno.1997.4941;
RA Fisher S.E., Ciccodicola A., Tanaka K., Curci A., Desicato S., D'Urso M.,
RA Craig I.W.;
RT "Sequence-based exon prediction around the synaptophysin locus reveals a
RT gene-rich area containing novel genes in human proximal Xp.";
RL Genomics 45:340-347(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Thymus;
RX PubMed=16344560; DOI=10.1101/gr.4039406;
RA Kimura K., Wakamatsu A., Suzuki Y., Ota T., Nishikawa T., Yamashita R.,
RA Yamamoto J., Sekine M., Tsuritani K., Wakaguri H., Ishii S., Sugiyama T.,
RA Saito K., Isono Y., Irie R., Kushida N., Yoneyama T., Otsuka R., Kanda K.,
RA Yokoi T., Kondo H., Wagatsuma M., Murakawa K., Ishida S., Ishibashi T.,
RA Takahashi-Fujii A., Tanase T., Nagai K., Kikuchi H., Nakai K., Isogai T.,
RA Sugano S.;
RT "Diversification of transcriptional modulation: large-scale identification
RT and characterization of putative alternative promoters of human genes.";
RL Genome Res. 16:55-65(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: May play a role in cell differentiation in the intestinal
CC epithelium.
CC -!- INTERACTION:
CC Q04941; Q92482: AQP3; NbExp=3; IntAct=EBI-608347, EBI-2808854;
CC Q04941; O94778: AQP8; NbExp=3; IntAct=EBI-608347, EBI-19124986;
CC Q04941; P53365: ARFIP2; NbExp=5; IntAct=EBI-608347, EBI-638194;
CC Q04941; P07307-3: ASGR2; NbExp=3; IntAct=EBI-608347, EBI-12808270;
CC Q04941; P18859: ATP5PF; NbExp=3; IntAct=EBI-608347, EBI-2606700;
CC Q04941; Q13323: BIK; NbExp=3; IntAct=EBI-608347, EBI-700794;
CC Q04941; Q12983: BNIP3; NbExp=3; IntAct=EBI-608347, EBI-749464;
CC Q04941; P32246: CCR1; NbExp=3; IntAct=EBI-608347, EBI-608322;
CC Q04941; P19397: CD53; NbExp=3; IntAct=EBI-608347, EBI-6657396;
CC Q04941; P11912: CD79A; NbExp=3; IntAct=EBI-608347, EBI-7797864;
CC Q04941; Q9HA82: CERS4; NbExp=3; IntAct=EBI-608347, EBI-2622997;
CC Q04941; Q9H5X1: CIAO2A; NbExp=3; IntAct=EBI-608347, EBI-752069;
CC Q04941; O00501: CLDN5; NbExp=3; IntAct=EBI-608347, EBI-18400628;
CC Q04941; Q7Z7G2: CPLX4; NbExp=3; IntAct=EBI-608347, EBI-18013275;
CC Q04941; Q9BUF7-2: CRB3; NbExp=3; IntAct=EBI-608347, EBI-17233035;
CC Q04941; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-608347, EBI-6942903;
CC Q04941; P49447: CYB561; NbExp=3; IntAct=EBI-608347, EBI-8646596;
CC Q04941; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-608347, EBI-2680384;
CC Q04941; Q53TN4: CYBRD1; NbExp=3; IntAct=EBI-608347, EBI-8637742;
CC Q04941; Q6PI48: DARS2; NbExp=3; IntAct=EBI-608347, EBI-3917045;
CC Q04941; Q96KC8: DNAJC1; NbExp=3; IntAct=EBI-608347, EBI-296550;
CC Q04941; Q15125: EBP; NbExp=3; IntAct=EBI-608347, EBI-3915253;
CC Q04941; Q9NYP7: ELOVL5; NbExp=3; IntAct=EBI-608347, EBI-11037623;
CC Q04941; P54852: EMP3; NbExp=3; IntAct=EBI-608347, EBI-3907816;
CC Q04941; P22794: EVI2A; NbExp=3; IntAct=EBI-608347, EBI-2870359;
CC Q04941; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-608347, EBI-18304435;
CC Q04941; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-608347, EBI-18938272;
CC Q04941; Q969F0: FATE1; NbExp=3; IntAct=EBI-608347, EBI-743099;
CC Q04941; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-608347, EBI-12142257;
CC Q04941; Q8TDV0: GPR151; NbExp=3; IntAct=EBI-608347, EBI-11955647;
CC Q04941; Q8TED1: GPX8; NbExp=3; IntAct=EBI-608347, EBI-11721746;
CC Q04941; C9JCN9: HSBP1L1; NbExp=3; IntAct=EBI-608347, EBI-2685549;
CC Q04941; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-608347, EBI-1052304;
CC Q04941; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-608347, EBI-18053395;
CC Q04941; Q8N6L0: KASH5; NbExp=3; IntAct=EBI-608347, EBI-749265;
CC Q04941; Q86WI0: LHFPL1; NbExp=3; IntAct=EBI-608347, EBI-18268016;
CC Q04941; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-608347, EBI-2820517;
CC Q04941; Q9HCJ2: LRRC4C; NbExp=3; IntAct=EBI-608347, EBI-3925442;
CC Q04941; O14880: MGST3; NbExp=3; IntAct=EBI-608347, EBI-724754;
CC Q04941; Q9ULP0-2: NDRG4; NbExp=3; IntAct=EBI-608347, EBI-11978907;
CC Q04941; Q9H813: PACC1; NbExp=5; IntAct=EBI-608347, EBI-4319734;
CC Q04941; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-608347, EBI-716063;
CC Q04941; P57054: PIGP; NbExp=3; IntAct=EBI-608347, EBI-17630288;
CC Q04941; O14684: PTGES; NbExp=3; IntAct=EBI-608347, EBI-11161398;
CC Q04941; P15151: PVR; NbExp=3; IntAct=EBI-608347, EBI-3919694;
CC Q04941; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-608347, EBI-7545592;
CC Q04941; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-608347, EBI-10192441;
CC Q04941; Q99942: RNF5; NbExp=3; IntAct=EBI-608347, EBI-348482;
CC Q04941; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-608347, EBI-3920694;
CC Q04941; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-608347, EBI-17247926;
CC Q04941; O95470: SGPL1; NbExp=3; IntAct=EBI-608347, EBI-1046170;
CC Q04941; Q15849: SLC14A2; NbExp=3; IntAct=EBI-608347, EBI-1573290;
CC Q04941; P54219-3: SLC18A1; NbExp=3; IntAct=EBI-608347, EBI-17595455;
CC Q04941; Q96QE2: SLC2A13; NbExp=3; IntAct=EBI-608347, EBI-18082698;
CC Q04941; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-608347, EBI-17295964;
CC Q04941; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-608347, EBI-742688;
CC Q04941; P16150: SPN; NbExp=3; IntAct=EBI-608347, EBI-10049055;
CC Q04941; Q8WY91: THAP4; NbExp=3; IntAct=EBI-608347, EBI-726691;
CC Q04941; Q96DZ7: TM4SF19; NbExp=3; IntAct=EBI-608347, EBI-6448756;
CC Q04941; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-608347, EBI-8638294;
CC Q04941; Q9NW97: TMEM51; NbExp=3; IntAct=EBI-608347, EBI-726044;
CC Q04941; Q9BSE2: TMEM79; NbExp=4; IntAct=EBI-608347, EBI-8649725;
CC Q04941; O15393-2: TMPRSS2; NbExp=4; IntAct=EBI-608347, EBI-12345267;
CC Q04941; Q9Y320: TMX2; NbExp=3; IntAct=EBI-608347, EBI-6447886;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q04941-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q04941-2; Sequence=VSP_041602;
CC -!- TISSUE SPECIFICITY: Enriched in colonic mucosa. The expression of A4
CC follows a gradient along the crypto-villus axis with the most abundant
CC message occurring in the lower half of the crypt.
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DR EMBL; L09604; AAA35499.1; -; mRNA.
DR EMBL; U93305; AAB92356.1; -; Genomic_DNA.
DR EMBL; DB102321; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF196779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC109066; AAI09067.1; -; mRNA.
DR CCDS; CCDS14319.1; -. [Q04941-1]
DR PIR; S32567; S32567.
DR RefSeq; NP_002659.1; NM_002668.2. [Q04941-1]
DR AlphaFoldDB; Q04941; -.
DR BioGRID; 111369; 105.
DR IntAct; Q04941; 75.
DR MINT; Q04941; -.
DR STRING; 9606.ENSP00000365505; -.
DR TCDB; 1.A.64.5.2; the plasmolipin (plasmolipin) family.
DR GlyGen; Q04941; 2 sites.
DR iPTMnet; Q04941; -.
DR PhosphoSitePlus; Q04941; -.
DR SwissPalm; Q04941; -.
DR BioMuta; PLP2; -.
DR DMDM; 416563; -.
DR EPD; Q04941; -.
DR jPOST; Q04941; -.
DR MassIVE; Q04941; -.
DR MaxQB; Q04941; -.
DR PaxDb; Q04941; -.
DR PeptideAtlas; Q04941; -.
DR PRIDE; Q04941; -.
DR ProteomicsDB; 58301; -. [Q04941-1]
DR ProteomicsDB; 58302; -. [Q04941-2]
DR TopDownProteomics; Q04941-1; -. [Q04941-1]
DR Antibodypedia; 12063; 66 antibodies from 21 providers.
DR DNASU; 5355; -.
DR Ensembl; ENST00000376322.7; ENSP00000365500.3; ENSG00000102007.11. [Q04941-2]
DR Ensembl; ENST00000376327.6; ENSP00000365505.5; ENSG00000102007.11. [Q04941-1]
DR GeneID; 5355; -.
DR KEGG; hsa:5355; -.
DR MANE-Select; ENST00000376327.6; ENSP00000365505.5; NM_002668.3; NP_002659.1.
DR UCSC; uc004dmx.4; human. [Q04941-1]
DR CTD; 5355; -.
DR DisGeNET; 5355; -.
DR GeneCards; PLP2; -.
DR HGNC; HGNC:9087; PLP2.
DR HPA; ENSG00000102007; Low tissue specificity.
DR MIM; 300112; gene.
DR neXtProt; NX_Q04941; -.
DR OpenTargets; ENSG00000102007; -.
DR PharmGKB; PA33415; -.
DR VEuPathDB; HostDB:ENSG00000102007; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000158528; -.
DR HOGENOM; CLU_108546_4_0_1; -.
DR InParanoid; Q04941; -.
DR OMA; ICEMIFA; -.
DR PhylomeDB; Q04941; -.
DR TreeFam; TF317387; -.
DR PathwayCommons; Q04941; -.
DR SignaLink; Q04941; -.
DR BioGRID-ORCS; 5355; 8 hits in 705 CRISPR screens.
DR ChiTaRS; PLP2; human.
DR GeneWiki; PLP2; -.
DR GenomeRNAi; 5355; -.
DR Pharos; Q04941; Tbio.
DR PRO; PR:Q04941; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q04941; protein.
DR Bgee; ENSG00000102007; Expressed in gingival epithelium and 185 other tissues.
DR ExpressionAtlas; Q04941; baseline and differential.
DR Genevisible; Q04941; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; TAS:ProtInc.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:ProtInc.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0019956; F:chemokine binding; IPI:UniProtKB.
DR GO; GO:0015075; F:ion transmembrane transporter activity; TAS:ProtInc.
DR GO; GO:0006935; P:chemotaxis; NAS:UniProtKB.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; NAS:UniProtKB.
DR GO; GO:0006811; P:ion transport; TAS:ProtInc.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..152
FT /note="Proteolipid protein 2"
FT /id="PRO_0000156819"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 19..137
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 117..152
FT /note="LGLIATCLFGYDAYVTFPVRQPRHTAAPTDPADGPV -> KAMGAALKHRAK
FT GLRSQGPFLPLLLAEIV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16344560"
FT /id="VSP_041602"
FT VARIANT 91
FT /note="A -> S (in dbSNP:rs1802969)"
FT /id="VAR_011924"
SQ SEQUENCE 152 AA; 16691 MW; 689378A8C326206C CRC64;
MADSERLSAP GCWAACTNFS RTRKGILLFA EIILCLVILI CFSASTPGYS SLSVIEMILA
AIFFVVYMCD LHTKIPFINW PWSDFFRTLI AAILYLITSI VVLVERGNHS KIVAGVLGLI
ATCLFGYDAY VTFPVRQPRH TAAPTDPADG PV
