PLP2_MOUSE
ID PLP2_MOUSE Reviewed; 152 AA.
AC Q9R1Q7; Q3U4I3;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Proteolipid protein 2;
GN Name=Plp2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hayashi A., Hattori A., Okaze H., Kozuma S., Seki N., Saito T.;
RT "Mouse proteolipid protein 2 (PLP2).";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Lung, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in cell differentiation in the intestinal
CC epithelium. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
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DR EMBL; AB031292; BAA83500.1; -; mRNA.
DR EMBL; AK003522; BAB22835.1; -; mRNA.
DR EMBL; AK011282; BAB27515.1; -; mRNA.
DR EMBL; AK154228; BAE32448.1; -; mRNA.
DR EMBL; BC083078; AAH83078.1; -; mRNA.
DR CCDS; CCDS40842.1; -.
DR RefSeq; NP_062729.1; NM_019755.5.
DR AlphaFoldDB; Q9R1Q7; -.
DR BioGRID; 202255; 3.
DR IntAct; Q9R1Q7; 3.
DR STRING; 10090.ENSMUSP00000033486; -.
DR iPTMnet; Q9R1Q7; -.
DR PhosphoSitePlus; Q9R1Q7; -.
DR SwissPalm; Q9R1Q7; -.
DR EPD; Q9R1Q7; -.
DR jPOST; Q9R1Q7; -.
DR MaxQB; Q9R1Q7; -.
DR PaxDb; Q9R1Q7; -.
DR PRIDE; Q9R1Q7; -.
DR ProteomicsDB; 289450; -.
DR DNASU; 18824; -.
DR Ensembl; ENSMUST00000033486; ENSMUSP00000033486; ENSMUSG00000031146.
DR Ensembl; ENSMUST00000071118; ENSMUSP00000132645; ENSMUSG00000057762.
DR GeneID; 18824; -.
DR KEGG; mmu:18824; -.
DR UCSC; uc009slx.1; mouse.
DR CTD; 5355; -.
DR MGI; MGI:1298382; Plp2.
DR VEuPathDB; HostDB:ENSMUSG00000031146; -.
DR VEuPathDB; HostDB:ENSMUSG00000057762; -.
DR eggNOG; KOG4788; Eukaryota.
DR GeneTree; ENSGT00940000158528; -.
DR HOGENOM; CLU_108546_4_0_1; -.
DR InParanoid; Q9R1Q7; -.
DR OMA; ICEMIFA; -.
DR OrthoDB; 1521294at2759; -.
DR PhylomeDB; Q9R1Q7; -.
DR TreeFam; TF317387; -.
DR BioGRID-ORCS; 18824; 4 hits in 74 CRISPR screens.
DR ChiTaRS; Plp2; mouse.
DR PRO; PR:Q9R1Q7; -.
DR Proteomes; UP000000589; Chromosome 13.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9R1Q7; protein.
DR Bgee; ENSMUSG00000031146; Expressed in granulocyte and 129 other tissues.
DR ExpressionAtlas; Q9R1Q7; baseline and differential.
DR Genevisible; Q9R1Q7; MM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0019956; F:chemokine binding; ISS:UniProtKB.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..152
FT /note="Proteolipid protein 2"
FT /id="PRO_0000156820"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 19..138
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
SQ SEQUENCE 152 AA; 16608 MW; C651A5E43B2909D6 CRC64;
MADSERLSAP GCWLACTSFS RTKKGILLFA EIILCLVILI CFSASTTSAY SSLSVIEMIC
AAVLLVFYTC DLHSKISFIN WPWTDFFRSL IATILYLITS IVVLVEGRGS SRVVAGILGL
LATLLFGYDA YITFPLKQQR HTAAPTDPTD GP
