ID   PLP3_ORYSJ              Reviewed;         413 AA.
AC   Q8H5D4; Q0D8M8;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Patatin-like protein 3;
DE            Short=OsPLP3;
DE            EC=3.1.1.-;
GN   Name=PLP3; OrderedLocusNames=Os07g0144500, LOC_Os07g05110;
GN   ORFNames=OJ1343_B12.121;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
CC   -!- FUNCTION: Possesses non-specific lipolytic acyl hydrolase (LAH)
CC       activity. Hydrolyzes phospholipids as well as galactolipids. May play a
CC       role in disease resistance (By similarity). {ECO:0000250}.
CC   -!- DOMAIN: The nitrogen atoms of the two glycine residues in the GGXR
CC       motif define the oxyanion hole, and stabilize the oxyanion that forms
CC       during the nucleophilic attack by the catalytic serine during substrate
CC       cleavage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the patatin family. {ECO:0000305}.
CC   -!- CAUTION: Lacks the conserved Asp residue expected to act as the active
CC       site proton acceptor. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP003824; BAC19963.1; -; Genomic_DNA.
DR   EMBL; AP008213; BAF20795.2; -; Genomic_DNA.
DR   EMBL; AP014963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_015646372.1; XM_015790886.1.
DR   AlphaFoldDB; Q8H5D4; -.
DR   SMR; Q8H5D4; -.
DR   STRING; 4530.OS07T0144500-00; -.
DR   PaxDb; Q8H5D4; -.
DR   PRIDE; Q8H5D4; -.
DR   GeneID; 4342389; -.
DR   KEGG; osa:4342389; -.
DR   eggNOG; KOG0513; Eukaryota.
DR   InParanoid; Q8H5D4; -.
DR   OrthoDB; 1209603at2759; -.
DR   Proteomes; UP000000763; Chromosome 7.
DR   Proteomes; UP000059680; Chromosome 7.
DR   GO; GO:0016298; F:lipase activity; IEA:UniProt.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002641; PNPLA_dom.
DR   SUPFAM; SSF52151; SSF52151; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Lipid degradation; Lipid metabolism; Plant defense;
KW   Reference proteome.
FT   CHAIN           1..413
FT                   /note="Patatin-like protein 3"
FT                   /id="PRO_0000425824"
FT   DOMAIN          54..245
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   REGION          384..413
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           58..61
FT                   /note="GGXR"
FT   ACT_SITE        100
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   413 AA;  43029 MW;  493083E35F260D7E CRC64;
     MEAGQDDAAD RLTYEIFSIL ESKFLFGYGG GGGGETKSLQ CAPPVSRGNR VCVLSVDGGA
     RPEDGLLAAA ALVRLEAAVQ RRAGSKAARL ADFFDVAAGS GAGGVLAAML FARGPCGRPM
     YSADDALGFL LRRVRRRGWS SRAGGLLRRP AGAFHKVFGE LTLRDTVRPV LVPCYDLATR
     APFLFSRADA AQSPAYDFRL RDACAATCAP SGGGAAVEAS SVDGVTRITA VGSGVALGNP
     TAAAITHVLN NRREFPAAAG VDNLLVISIG TGEAAGSSSR HRARTPVIAR IAAEGASDMV
     DQAVAMAFGQ HRTSNYVRIQ GMGVARRRGG GVACGGETAE KAVWVAEAML QQRNVEAVMF
     QGRRLAGETN AEKVERFARE LIKEHGRRKQ HVPPAASGGG GGGLDCHVSK KQP