ID   PLPHP_BOVIN             Reviewed;         273 AA.
AC   Q3T0G5;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Pyridoxal phosphate homeostasis protein {ECO:0000255|HAMAP-Rule:MF_03225};
DE            Short=PLP homeostasis protein {ECO:0000255|HAMAP-Rule:MF_03225};
DE   AltName: Full=Proline synthase co-transcribed bacterial homolog protein {ECO:0000255|HAMAP-Rule:MF_03225};
DE   AltName: Full=Pyridoxal phosphate-binding protein {ECO:0000250|UniProtKB:O94903};
GN   Name=PLPBP {ECO:0000255|HAMAP-Rule:MF_03225};
GN   Synonyms=PROSC {ECO:0000255|HAMAP-Rule:MF_03225};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be
CC       involved in intracellular homeostatic regulation of pyridoxal 5'-
CC       phosphate (PLP), the active form of vitamin B6. {ECO:0000255|HAMAP-
CC       Rule:MF_03225}.
CC   -!- SIMILARITY: Belongs to the pyridoxal phosphate-binding protein
CC       YggS/PROSC family. {ECO:0000255|HAMAP-Rule:MF_03225}.
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DR   EMBL; BC102405; AAI02406.1; -; mRNA.
DR   RefSeq; NP_001029529.1; NM_001034357.1.
DR   AlphaFoldDB; Q3T0G5; -.
DR   SMR; Q3T0G5; -.
DR   STRING; 9913.ENSBTAP00000039600; -.
DR   PaxDb; Q3T0G5; -.
DR   PeptideAtlas; Q3T0G5; -.
DR   PRIDE; Q3T0G5; -.
DR   Ensembl; ENSBTAT00000039812; ENSBTAP00000039600; ENSBTAG00000011075.
DR   GeneID; 509643; -.
DR   KEGG; bta:509643; -.
DR   CTD; 11212; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011075; -.
DR   VGNC; VGNC:33043; PLPBP.
DR   eggNOG; KOG3157; Eukaryota.
DR   GeneTree; ENSGT00390000004928; -.
DR   HOGENOM; CLU_059988_2_1_1; -.
DR   InParanoid; Q3T0G5; -.
DR   OMA; IEWHMIG; -.
DR   OrthoDB; 1423577at2759; -.
DR   TreeFam; TF314637; -.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000011075; Expressed in caput epididymis and 104 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR   Gene3D; 3.20.20.10; -; 1.
DR   HAMAP; MF_02087; PLP_homeostasis; 1.
DR   InterPro; IPR001608; Ala_racemase_N.
DR   InterPro; IPR029066; PLP-binding_barrel.
DR   InterPro; IPR011078; PyrdxlP_homeostasis.
DR   PANTHER; PTHR10146; PTHR10146; 1.
DR   Pfam; PF01168; Ala_racemase_N; 1.
DR   PIRSF; PIRSF004848; YBL036c_PLPDEIII; 1.
DR   SUPFAM; SSF51419; SSF51419; 1.
DR   TIGRFAMs; TIGR00044; TIGR00044; 1.
DR   PROSITE; PS01211; UPF0001; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..273
FT                   /note="Pyridoxal phosphate homeostasis protein"
FT                   /id="PRO_0000249596"
FT   REGION          251..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         6
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O94903"
FT   MOD_RES         47
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03225"
FT   MOD_RES         69
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Z2Y8"
FT   MOD_RES         125
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Z2Y8"
FT   MOD_RES         226
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O94903"
FT   MOD_RES         244
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O94903"
SQ   SEQUENCE   273 AA;  29943 MW;  46FBEF6CEA5E41FE CRC64;
     MWKAGSMSAE LGIGFALRAV NERVQQAVAR RPRDLPAIQP RLVAVSKTKP ADMVIEAYSH
     GQRTFGENYV QELLEKASNP QILSSCPEIK WHFIGHLQKQ NVNKLMAVPN LSMLETVDSV
     KLADKVNSAW QKKGSPERLK VMVQINTSGE ASKHGLPPAE MAALVEHINA KCPSLEFVGL
     MTIGSFGHDL SQGPNPDFQV LLSLREELCR KLGAPPEQVE LSMGMSVDFQ HAIEVGSTNV
     RIGSTIFGER DYSKKTDKPA AELQAPEEVA QAH