ID   PLPHP_CAEEL             Reviewed;         244 AA.
AC   P52057;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Pyridoxal phosphate homeostasis protein {ECO:0000255|HAMAP-Rule:MF_03225};
DE            Short=PLP homeostasis protein {ECO:0000255|HAMAP-Rule:MF_03225};
GN   ORFNames=F09E5.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be
CC       involved in intracellular homeostatic regulation of pyridoxal 5'-
CC       phosphate (PLP), the active form of vitamin B6. {ECO:0000255|HAMAP-
CC       Rule:MF_03225}.
CC   -!- SIMILARITY: Belongs to the pyridoxal phosphate-binding protein
CC       YggS/PROSC family. {ECO:0000255|HAMAP-Rule:MF_03225}.
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DR   EMBL; FO081044; CCD68760.1; -; Genomic_DNA.
DR   PIR; T15996; T15996.
DR   RefSeq; NP_495001.1; NM_062600.5.
DR   AlphaFoldDB; P52057; -.
DR   SMR; P52057; -.
DR   BioGRID; 39251; 4.
DR   STRING; 6239.F09E5.8; -.
DR   EPD; P52057; -.
DR   PaxDb; P52057; -.
DR   PeptideAtlas; P52057; -.
DR   EnsemblMetazoa; F09E5.8.1; F09E5.8.1; WBGene00017286.
DR   GeneID; 173906; -.
DR   KEGG; cel:CELE_F09E5.8; -.
DR   UCSC; F09E5.8; c. elegans.
DR   CTD; 173906; -.
DR   WormBase; F09E5.8; CE02615; WBGene00017286; -.
DR   eggNOG; KOG3157; Eukaryota.
DR   GeneTree; ENSGT00390000004928; -.
DR   HOGENOM; CLU_059988_2_1_1; -.
DR   InParanoid; P52057; -.
DR   OMA; IEWHMIG; -.
DR   OrthoDB; 1423577at2759; -.
DR   PhylomeDB; P52057; -.
DR   PRO; PR:P52057; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00017286; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR   Gene3D; 3.20.20.10; -; 1.
DR   HAMAP; MF_02087; PLP_homeostasis; 1.
DR   InterPro; IPR001608; Ala_racemase_N.
DR   InterPro; IPR029066; PLP-binding_barrel.
DR   InterPro; IPR011078; PyrdxlP_homeostasis.
DR   PANTHER; PTHR10146; PTHR10146; 1.
DR   Pfam; PF01168; Ala_racemase_N; 1.
DR   PIRSF; PIRSF004848; YBL036c_PLPDEIII; 1.
DR   SUPFAM; SSF51419; SSF51419; 1.
DR   TIGRFAMs; TIGR00044; TIGR00044; 1.
DR   PROSITE; PS01211; UPF0001; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..244
FT                   /note="Pyridoxal phosphate homeostasis protein"
FT                   /id="PRO_0000163212"
FT   MOD_RES         37
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03225"
SQ   SEQUENCE   244 AA;  27196 MW;  4D6F3F3552A86A5A CRC64;
     MSIEIVQKSL FNIIEAVADA VTASQATKRC RLVAVSKTKS ADLIEACYSQ NQRHFGENYV
     QELEEKSDVL ASKCLDIRWH FIGQVQSNKI GKICNSPGLW CVETVETEKH ARIFDKEWSK
     HGANLSPLRV LVQVNTSGED NKGGIEIGEA PKLAEFIRKE CQNLKFDGFM TIGSFDNSHA
     SGENPDFEKL FKVRQTWAEQ TGESADSVEL SMGMSDDFLQ AIHQGATSVR VGSKLFGARE
     YKNK