ID   PLPHP_DICDI             Reviewed;         255 AA.
AC   Q1ZXI6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Pyridoxal phosphate homeostasis protein {ECO:0000255|HAMAP-Rule:MF_03225};
DE            Short=PLP homeostasis protein {ECO:0000255|HAMAP-Rule:MF_03225};
GN   Name=prosc; ORFNames=DDB_G0278713;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be
CC       involved in intracellular homeostatic regulation of pyridoxal 5'-
CC       phosphate (PLP), the active form of vitamin B6. {ECO:0000255|HAMAP-
CC       Rule:MF_03225}.
CC   -!- SIMILARITY: Belongs to the pyridoxal phosphate-binding protein
CC       YggS/PROSC family. {ECO:0000255|HAMAP-Rule:MF_03225}.
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DR   EMBL; AAFI02000023; EAS66901.2; -; Genomic_DNA.
DR   RefSeq; XP_001134585.2; XM_001134585.2.
DR   AlphaFoldDB; Q1ZXI6; -.
DR   SMR; Q1ZXI6; -.
DR   STRING; 44689.DDB0305032; -.
DR   PaxDb; Q1ZXI6; -.
DR   PRIDE; Q1ZXI6; -.
DR   EnsemblProtists; EAS66901; EAS66901; DDB_G0278713.
DR   GeneID; 8621656; -.
DR   KEGG; ddi:DDB_G0278713; -.
DR   dictyBase; DDB_G0278713; prosc.
DR   eggNOG; KOG3157; Eukaryota.
DR   HOGENOM; CLU_059988_2_1_1; -.
DR   InParanoid; Q1ZXI6; -.
DR   OMA; IEWHMIG; -.
DR   PhylomeDB; Q1ZXI6; -.
DR   PRO; PR:Q1ZXI6; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR   Gene3D; 3.20.20.10; -; 1.
DR   HAMAP; MF_02087; PLP_homeostasis; 1.
DR   InterPro; IPR001608; Ala_racemase_N.
DR   InterPro; IPR029066; PLP-binding_barrel.
DR   InterPro; IPR011078; PyrdxlP_homeostasis.
DR   PANTHER; PTHR10146; PTHR10146; 1.
DR   Pfam; PF01168; Ala_racemase_N; 1.
DR   PIRSF; PIRSF004848; YBL036c_PLPDEIII; 1.
DR   SUPFAM; SSF51419; SSF51419; 1.
DR   TIGRFAMs; TIGR00044; TIGR00044; 1.
DR   PROSITE; PS01211; UPF0001; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..255
FT                   /note="Pyridoxal phosphate homeostasis protein"
FT                   /id="PRO_0000328898"
FT   MOD_RES         40
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03225"
SQ   SEQUENCE   255 AA;  28985 MW;  8B59463EAC93B4B6 CRC64;
     MMDENDVKEL ISSYKNIKDR VEIISNKFDR HNVKLVAVSK TKPTEMIRIL YDKGHRHFGE
     NYIQELVSKS EELSELNEIK WHFIGSIQSN KSKILTSVKN LYVVETVENK KILDKLAKSL
     LNNEENNNNN NNNNNKKLNI MIQVNTSGEE SKSGCKPEEC LDLVKHCLED NNCKNSLNFL
     GLMTIGNPNA TPDQPDFKCL VDCKNNISKQ LNIPLDSIEL SMGMSHDFEP AIEFGSTSVR
     VGSAIFGERD YSNKK