ID   PLPHP_HELPJ             Reviewed;         222 AA.
AC   Q9ZKF2;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Pyridoxal phosphate homeostasis protein {ECO:0000255|HAMAP-Rule:MF_02087};
DE            Short=PLP homeostasis protein {ECO:0000255|HAMAP-Rule:MF_02087};
GN   OrderedLocusNames=jhp_0986;
OS   Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J99 / ATCC 700824;
RX   PubMed=9923682; DOI=10.1038/16495;
RA   Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA   Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA   Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA   Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT   "Genomic sequence comparison of two unrelated isolates of the human gastric
RT   pathogen Helicobacter pylori.";
RL   Nature 397:176-180(1999).
CC   -!- FUNCTION: Pyridoxal 5'-phosphate (PLP)-binding protein, which is
CC       involved in PLP homeostasis. {ECO:0000255|HAMAP-Rule:MF_02087}.
CC   -!- SIMILARITY: Belongs to the pyridoxal phosphate-binding protein
CC       YggS/PROSC family. {ECO:0000255|HAMAP-Rule:MF_02087}.
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DR   EMBL; AE001439; AAD06567.1; -; Genomic_DNA.
DR   PIR; E71864; E71864.
DR   RefSeq; WP_000888231.1; NZ_CP011330.1.
DR   AlphaFoldDB; Q9ZKF2; -.
DR   SMR; Q9ZKF2; -.
DR   STRING; 85963.jhp_0986; -.
DR   EnsemblBacteria; AAD06567; AAD06567; jhp_0986.
DR   KEGG; hpj:jhp_0986; -.
DR   PATRIC; fig|85963.30.peg.1605; -.
DR   eggNOG; COG0325; Bacteria.
DR   OMA; PLEWHMI; -.
DR   Proteomes; UP000000804; Chromosome.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.10; -; 1.
DR   HAMAP; MF_02087; PLP_homeostasis; 1.
DR   InterPro; IPR001608; Ala_racemase_N.
DR   InterPro; IPR029066; PLP-binding_barrel.
DR   InterPro; IPR011078; PyrdxlP_homeostasis.
DR   PANTHER; PTHR10146; PTHR10146; 1.
DR   Pfam; PF01168; Ala_racemase_N; 1.
DR   PIRSF; PIRSF004848; YBL036c_PLPDEIII; 1.
DR   SUPFAM; SSF51419; SSF51419; 1.
DR   TIGRFAMs; TIGR00044; TIGR00044; 1.
DR   PROSITE; PS01211; UPF0001; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate.
FT   CHAIN           1..222
FT                   /note="Pyridoxal phosphate homeostasis protein"
FT                   /id="PRO_0000163201"
FT   MOD_RES         35
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02087"
SQ   SEQUENCE   222 AA;  25060 MW;  79A7FB4DEC3F4721 CRC64;
     MLDYRQRIDT LITKIEKARI AYSRHHIVKI VAVSKNASPE AIQHYYNCSQ RAFGENKVQD
     LKIKMHSLEH LPLEWHMIGS LQENKINALL SLKPALLHSL DSLKLALKIE KRCEILGVNL
     NALLQVNSAY EESKSGVVPE EALETYSQIS ETCKRLKLKG LMCIGAHTDD ETKIEKSFTT
     TKKLFDQIKN ASVLSMGMSD DFELAIACGA NLLRIGSFLF KE