ID   PLPHP_HELPY             Reviewed;         222 AA.
AC   O25156;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Pyridoxal phosphate homeostasis protein {ECO:0000255|HAMAP-Rule:MF_02087};
DE            Short=PLP homeostasis protein {ECO:0000255|HAMAP-Rule:MF_02087};
GN   OrderedLocusNames=HP_0395;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Pyridoxal 5'-phosphate (PLP)-binding protein, which is
CC       involved in PLP homeostasis. {ECO:0000255|HAMAP-Rule:MF_02087}.
CC   -!- SIMILARITY: Belongs to the pyridoxal phosphate-binding protein
CC       YggS/PROSC family. {ECO:0000255|HAMAP-Rule:MF_02087}.
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DR   EMBL; AE000511; AAD07459.1; -; Genomic_DNA.
DR   PIR; C64569; C64569.
DR   RefSeq; NP_207193.1; NC_000915.1.
DR   RefSeq; WP_000888213.1; NC_018939.1.
DR   AlphaFoldDB; O25156; -.
DR   SMR; O25156; -.
DR   STRING; 85962.C694_02005; -.
DR   PaxDb; O25156; -.
DR   EnsemblBacteria; AAD07459; AAD07459; HP_0395.
DR   KEGG; hpy:HP_0395; -.
DR   PATRIC; fig|85962.47.peg.419; -.
DR   eggNOG; COG0325; Bacteria.
DR   OMA; PLEWHMI; -.
DR   PhylomeDB; O25156; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR   Gene3D; 3.20.20.10; -; 1.
DR   HAMAP; MF_02087; PLP_homeostasis; 1.
DR   InterPro; IPR001608; Ala_racemase_N.
DR   InterPro; IPR029066; PLP-binding_barrel.
DR   InterPro; IPR011078; PyrdxlP_homeostasis.
DR   PANTHER; PTHR10146; PTHR10146; 1.
DR   Pfam; PF01168; Ala_racemase_N; 1.
DR   PIRSF; PIRSF004848; YBL036c_PLPDEIII; 1.
DR   SUPFAM; SSF51419; SSF51419; 1.
DR   TIGRFAMs; TIGR00044; TIGR00044; 1.
DR   PROSITE; PS01211; UPF0001; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..222
FT                   /note="Pyridoxal phosphate homeostasis protein"
FT                   /id="PRO_0000163200"
FT   MOD_RES         35
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02087"
SQ   SEQUENCE   222 AA;  25011 MW;  5A6B172FD3585949 CRC64;
     MLDYRQKIDA LITKIEKART AYSRHHIVKI VAVSKNASPE AIQHYYNCSQ RAFGENKVQD
     LKTKMHSLEH LPLEWHMIGS LQENKINALL SLKPALLHSL DSLKLALKIE KRCEILGVNL
     NALLQVNSAY EESKSGVVPE EALEIYSQIS ETCKHLKLKG LMCIGAHTDD EKEIEKSFIT
     TKKLFDQIKN ASVLSMGMSD DFELAIACGA NLLRIGSFLF KE