ID   PLPHP_MYCTU             Reviewed;         258 AA.
AC   P9WFQ7; L0T8S0; O06228; P67083;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Pyridoxal phosphate homeostasis protein {ECO:0000255|HAMAP-Rule:MF_02087};
DE            Short=PLP homeostasis protein {ECO:0000255|HAMAP-Rule:MF_02087};
GN   OrderedLocusNames=Rv2148c; ORFNames=MTCY270.20;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Pyridoxal 5'-phosphate (PLP)-binding protein, which is
CC       involved in PLP homeostasis. {ECO:0000255|HAMAP-Rule:MF_02087}.
CC   -!- SIMILARITY: Belongs to the pyridoxal phosphate-binding protein
CC       YggS/PROSC family. {ECO:0000255|HAMAP-Rule:MF_02087}.
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DR   EMBL; AL123456; CCP44924.1; -; Genomic_DNA.
DR   PIR; H70578; H70578.
DR   RefSeq; NP_216664.1; NC_000962.3.
DR   RefSeq; WP_003411137.1; NZ_NVQJ01000044.1.
DR   AlphaFoldDB; P9WFQ7; -.
DR   SMR; P9WFQ7; -.
DR   STRING; 83332.Rv2148c; -.
DR   PaxDb; P9WFQ7; -.
DR   DNASU; 888127; -.
DR   GeneID; 888127; -.
DR   KEGG; mtu:Rv2148c; -.
DR   PATRIC; fig|83332.111.peg.2394; -.
DR   TubercuList; Rv2148c; -.
DR   eggNOG; COG0325; Bacteria.
DR   OMA; IEWHMIG; -.
DR   PhylomeDB; P9WFQ7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR   Gene3D; 3.20.20.10; -; 1.
DR   HAMAP; MF_02087; PLP_homeostasis; 1.
DR   InterPro; IPR001608; Ala_racemase_N.
DR   InterPro; IPR029066; PLP-binding_barrel.
DR   InterPro; IPR011078; PyrdxlP_homeostasis.
DR   PANTHER; PTHR10146; PTHR10146; 1.
DR   Pfam; PF01168; Ala_racemase_N; 1.
DR   PIRSF; PIRSF004848; YBL036c_PLPDEIII; 1.
DR   SUPFAM; SSF51419; SSF51419; 1.
DR   TIGRFAMs; TIGR00044; TIGR00044; 1.
DR   PROSITE; PS01211; UPF0001; 1.
PE   1: Evidence at protein level;
KW   Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..258
FT                   /note="Pyridoxal phosphate homeostasis protein"
FT                   /id="PRO_0000163203"
FT   MOD_RES         47
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02087"
SQ   SEQUENCE   258 AA;  27693 MW;  6C534D96E9368BB2 CRC64;
     MAADLSAYPD RESELTHALA AMRSRLAAAA EAAGRNVGEI ELLPITKFFP ATDVAILFRL
     GCRSVGESRE QEASAKMAEL NRLLAAAELG HSGGVHWHMV GRIQRNKAGS LARWAHTAHS
     VDSSRLVTAL DRAVVAALAE HRRGERLRVY VQVSLDGDGS RGGVDSTTPG AVDRICAQVQ
     ESEGLELVGL MGIPPLDWDP DEAFDRLQSE HNRVRAMFPH AIGLSAGMSN DLEVAVKHGS
     TCVRVGTALL GPRRLRSP