ID   PLPHP_PSEAE             Reviewed;         230 AA.
AC   P24562; P25255;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Pyridoxal phosphate homeostasis protein {ECO:0000255|HAMAP-Rule:MF_02087};
DE            Short=PLP homeostasis protein {ECO:0000255|HAMAP-Rule:MF_02087};
GN   OrderedLocusNames=PA0394;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=1676385; DOI=10.1016/0378-1119(91)90221-v;
RA   Whitchurch C.B., Hobbs M., Livingston S.P., Krishnapillai V., Mattick J.S.;
RT   "Characterisation of a Pseudomonas aeruginosa twitching motility gene and
RT   evidence for a specialised protein export system widespread in
RT   eubacteria.";
RL   Gene 101:33-44(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 202-230.
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=2107123; DOI=10.1016/0378-1119(90)90121-7;
RA   Savioz A., Jeenes D.J., Kocher H.P., Haas D.;
RT   "Comparison of proC and other housekeeping genes of Pseudomonas aeruginosa
RT   with their counterparts in Escherichia coli.";
RL   Gene 86:107-111(1990).
CC   -!- FUNCTION: Perhaps involved in proline biosynthesis.
CC   -!- FUNCTION: Pyridoxal 5'-phosphate (PLP)-binding protein, which is
CC       involved in PLP homeostasis. {ECO:0000255|HAMAP-Rule:MF_02087}.
CC   -!- SIMILARITY: Belongs to the pyridoxal phosphate-binding protein
CC       YggS/PROSC family. {ECO:0000255|HAMAP-Rule:MF_02087}.
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DR   EMBL; M55524; AAA25959.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG03783.1; -; Genomic_DNA.
DR   EMBL; M33557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; JN0060; JN0060.
DR   RefSeq; NP_249085.1; NC_002516.2.
DR   RefSeq; WP_003084549.1; NZ_QZGE01000016.1.
DR   AlphaFoldDB; P24562; -.
DR   SMR; P24562; -.
DR   STRING; 287.DR97_3362; -.
DR   PaxDb; P24562; -.
DR   PRIDE; P24562; -.
DR   EnsemblBacteria; AAG03783; AAG03783; PA0394.
DR   GeneID; 878395; -.
DR   KEGG; pae:PA0394; -.
DR   PATRIC; fig|208964.12.peg.415; -.
DR   PseudoCAP; PA0394; -.
DR   HOGENOM; CLU_059988_0_1_6; -.
DR   InParanoid; P24562; -.
DR   OMA; PLEWHMI; -.
DR   PhylomeDB; P24562; -.
DR   BioCyc; PAER208964:G1FZ6-398-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR   Gene3D; 3.20.20.10; -; 1.
DR   HAMAP; MF_02087; PLP_homeostasis; 1.
DR   InterPro; IPR001608; Ala_racemase_N.
DR   InterPro; IPR029066; PLP-binding_barrel.
DR   InterPro; IPR011078; PyrdxlP_homeostasis.
DR   PANTHER; PTHR10146; PTHR10146; 1.
DR   Pfam; PF01168; Ala_racemase_N; 1.
DR   PIRSF; PIRSF004848; YBL036c_PLPDEIII; 1.
DR   SUPFAM; SSF51419; SSF51419; 1.
DR   TIGRFAMs; TIGR00044; TIGR00044; 1.
DR   PROSITE; PS01211; UPF0001; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..230
FT                   /note="Pyridoxal phosphate homeostasis protein"
FT                   /id="PRO_0000163206"
FT   MOD_RES         36
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02087"
SQ   SEQUENCE   230 AA;  24505 MW;  594AE89A1E706768 CRC64;
     MSTIAENIAK VAARIREAAQ AAGRDPATVG LLAVSKTKPA AAVREAHAAG LRDFGENYLQ
     EALGKQAELA DLPLNWHFIG PIQSNKTRPI AEHFQWVHSV DRLKIAQRLS EQRPAGLPPL
     NVCLQVNVSG EASKSGCAPE DLPALAEAVK QLPNLRLRGL MAIPEPTAER AAQHAAFARL
     RELLLDLNLG LDTLSMGMSD DLEAAIGEGA TWVRIGTALF GARDYGAPAS