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PLPL6_CAEEL
ID   PLPL6_CAEEL             Reviewed;        1095 AA.
AC   Q21534; Q20023;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 3.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Putative patatin-like phospholipase domain-containing protein M110.7 {ECO:0000305};
DE            EC=3.1.1.- {ECO:0000250|UniProtKB:Q3TRM4};
GN   ORFNames=M110.7 {ECO:0000312|WormBase:M110.7};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NTE family. {ECO:0000305}.
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DR   EMBL; BX284602; CAA90264.3; -; Genomic_DNA.
DR   EMBL; Z49966; CAA90264.3; JOINED; Genomic_DNA.
DR   PIR; T21745; T21745.
DR   RefSeq; NP_495734.3; NM_063333.3.
DR   AlphaFoldDB; Q21534; -.
DR   SMR; Q21534; -.
DR   STRING; 6239.M110.7; -.
DR   EPD; Q21534; -.
DR   PaxDb; Q21534; -.
DR   PRIDE; Q21534; -.
DR   EnsemblMetazoa; M110.7.1; M110.7.1; WBGene00010915.
DR   GeneID; 187474; -.
DR   KEGG; cel:CELE_M110.7; -.
DR   UCSC; M110.7; c. elegans.
DR   CTD; 187474; -.
DR   WormBase; M110.7; CE43244; WBGene00010915; -.
DR   eggNOG; KOG2968; Eukaryota.
DR   HOGENOM; CLU_000960_1_0_1; -.
DR   InParanoid; Q21534; -.
DR   OMA; LISKCWK; -.
DR   OrthoDB; 253518at2759; -.
DR   PhylomeDB; Q21534; -.
DR   Reactome; R-CEL-6814848; Glycerophospholipid catabolism.
DR   PRO; PR:Q21534; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00010915; Expressed in adult organism and 1 other tissue.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004622; F:lysophospholipase activity; IBA:GO_Central.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 2.
DR   Gene3D; 2.60.120.10; -; 3.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR001423; LysoPLipase_patatin_CS.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SMART; SM00100; cNMP; 3.
DR   SUPFAM; SSF51206; SSF51206; 3.
DR   SUPFAM; SSF52151; SSF52151; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS51635; PNPLA; 1.
DR   PROSITE; PS01237; UPF0028; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Lipid degradation; Lipid metabolism; Membrane;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..1095
FT                   /note="Putative patatin-like phospholipase domain-
FT                   containing protein M110.7"
FT                   /id="PRO_0000172530"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          768..935
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   REGION          75..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           772..777
FT                   /note="GXGXXG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   MOTIF           799..803
FT                   /note="GXSXG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   MOTIF           922..924
FT                   /note="DGA/G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   COMPBIAS        75..105
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        801
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   ACT_SITE        922
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   BINDING         144..237
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00060"
FT   BINDING         327..416
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00060"
FT   BINDING         450..509
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00060"
SQ   SEQUENCE   1095 AA;  124856 MW;  A52D68E2BC62CB98 CRC64;
     MLHYLLSVLL LIFENILELC MCITLVILIY YFWPSKQLED ATLQYFPDTT QNSSEVFIDP
     PERNPIFYPI SPLRHKKRSS KEEMTPDKKR DSSEKISKQP PRELFEPNEQ EQVPSHIKPE
     IFFVLKALEG LELPTTWQLD PKDVETLSID TGSVVLSPGR ANDVIVVVIS GELGIFTNVS
     LGDKRYDCNI KTLRSGESYF SQTSIIEILM NEKPNNKYIH LKALTSCRVA TYHLTSFHTS
     FIANPQQWIR TIQVVMTRLQ QCTLITCNMY LGIGGKCLNA KRKLPDSGKF KDFNKLTEAE
     QLNKGVEAIA QAMGIPDQSD KLREKVRKYE CQAGTVVTEE NSFEIDMIFV VFGKLRLKRG
     DLEHDDTGTS LTFDVYPGDM LPSMQILTNE PAMCSAKALE KTIYFKICRD EYIQFLFAHP
     VIYLRLAFHA LQFISPFARV FDMAVHWHRI ETGQALFRQG DKSDSMHIVM GGRLRAVDST
     KIIEEYGRLD LIGITDMAEK RPRRNTVMAV RFSHIVCIPE NLLSFVKIRY PQVGNKLLKL
     ISKCWKAPTP ETMSHVETTR NQNLRTIAIV PASRRVPLTE FTCELYNQLS KHVKTLRLSS
     SVVENYFESE VITKKADYGL MHWLNVQEIA YSLVLYQCDF HKTNWTRRCL RMADAILMVA
     LGTESKEEQV LAEALLSCNE KGVRQSKELV FLWPIDTPTP SGTAAWIKES YYSGYHHLRA
     PNRLFSFPLK TREKKIVEYY ETTVYGEISY QSDFSRLARI LTGNAIGIVF GGGGARGAAH
     AGALRALIEK KVQIDMVGGT SIGALFGSLY ATTPDIRAVG RMKDFFTDRL RNNILDVVRD
     LTWPYCGILT GHRFNLCVQR MLNDVNIEDC WVSFFCITTD LTSSSMRIHR NGIMWPVVRS
     SMSIAGYVPP ICDPQDGHLL LDGAYVNNLP ADIMRSLGAN VVIAIDVGMS DDNTNLRNYG
     FSISGTWCLF KRWWPFGEEL RVLNMNEVQN RLAYVCCVNQ MEIVKNAQYC YYVKLPIESF
     GIFDFSKFDQ AAQIGYDITK QKMEEFFEDS VATRRKLLGC ARNVRQTPQK SKNDNILSFV
     NMPVLPKPPS DIKSD
 
 
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