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PLPL7_CAEEL
ID   PLPL7_CAEEL             Reviewed;        1353 AA.
AC   Q02331; Q6LDE9; Q6LDF0; Q95PX1;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 3.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=Patatin-like phospholipase domain-containing protein ZK370.4 {ECO:0000305};
DE            EC=3.1.1.- {ECO:0000250|UniProtKB:A2AJ88};
GN   ORFNames=ZK370.4 {ECO:0000312|WormBase:ZK370.4b};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=b {ECO:0000312|WormBase:ZK370.4b};
CC         IsoId=Q02331-1; Sequence=Displayed;
CC       Name=a {ECO:0000312|WormBase:ZK370.4a};
CC         IsoId=Q02331-2; Sequence=VSP_006718;
CC   -!- SIMILARITY: Belongs to the NTE family. {ECO:0000305}.
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DR   EMBL; BX284603; CCD61723.1; -; Genomic_DNA.
DR   EMBL; BX284603; CCD61724.1; -; Genomic_DNA.
DR   PIR; S44665; S44665.
DR   RefSeq; NP_498926.2; NM_066525.2. [Q02331-2]
DR   RefSeq; NP_498927.2; NM_066526.4. [Q02331-1]
DR   AlphaFoldDB; Q02331; -.
DR   SMR; Q02331; -.
DR   STRING; 6239.ZK370.4b; -.
DR   iPTMnet; Q02331; -.
DR   EPD; Q02331; -.
DR   PaxDb; Q02331; -.
DR   PeptideAtlas; Q02331; -.
DR   PRIDE; Q02331; -.
DR   EnsemblMetazoa; ZK370.4a.1; ZK370.4a.1; WBGene00022718. [Q02331-2]
DR   EnsemblMetazoa; ZK370.4b.1; ZK370.4b.1; WBGene00022718. [Q02331-1]
DR   GeneID; 176225; -.
DR   KEGG; cel:CELE_ZK370.4; -.
DR   UCSC; ZK370.4b; c. elegans. [Q02331-1]
DR   CTD; 176225; -.
DR   WormBase; ZK370.4a; CE34454; WBGene00022718; -. [Q02331-2]
DR   WormBase; ZK370.4b; CE34455; WBGene00022718; -. [Q02331-1]
DR   eggNOG; KOG2968; Eukaryota.
DR   GeneTree; ENSGT00940000168388; -.
DR   InParanoid; Q02331; -.
DR   OMA; GHHHIRI; -.
DR   OrthoDB; 253518at2759; -.
DR   PhylomeDB; Q02331; -.
DR   Reactome; R-CEL-6814848; Glycerophospholipid catabolism.
DR   PRO; PR:Q02331; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00022718; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004622; F:lysophospholipase activity; IBA:GO_Central.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0046470; P:phosphatidylcholine metabolic process; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 3.
DR   Gene3D; 2.60.120.10; -; 3.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR001423; LysoPLipase_patatin_CS.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 3.
DR   Pfam; PF01734; Patatin; 1.
DR   SMART; SM00100; cNMP; 2.
DR   SUPFAM; SSF51206; SSF51206; 3.
DR   SUPFAM; SSF52151; SSF52151; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 3.
DR   PROSITE; PS51635; PNPLA; 1.
DR   PROSITE; PS01237; UPF0028; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Hydrolase; Lipid degradation; Lipid metabolism;
KW   Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..1353
FT                   /note="Patatin-like phospholipase domain-containing protein
FT                   ZK370.4"
FT                   /id="PRO_0000172529"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          942..1108
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   REGION          49..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          199..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1230..1249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1274..1293
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1305..1353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           946..951
FT                   /note="GXGXXG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   MOTIF           973..977
FT                   /note="GXSXG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   MOTIF           1095..1097
FT                   /note="DGA/G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   COMPBIAS        49..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..89
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1327..1347
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        975
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   ACT_SITE        1095
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   BINDING         245..372
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00060"
FT   BINDING         444..581
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00060"
FT   BINDING         570..692
FT                   /ligand="a nucleoside 3',5'-cyclic phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58464"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00060"
FT   VAR_SEQ         494..504
FT                   /note="Missing (in isoform a)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_006718"
SQ   SEQUENCE   1353 AA;  152396 MW;  9DAA023A87A27197 CRC64;
     MSFFYSLFAP LIFLVTFIYN HVLLILFTVC IIGAAAFFVS YYLFGYSNTP SSASSSATPS
     SRNSPNKERS KKVPTILETD NEDDEIRVNG SPKSGTPTNT QTIEPPTSLN LNMVNSASGS
     NLSGARRMRK RDWAKKLYKS LVQDSPGRTP TDESSDEENA NVVMGGGSVP RRRSKHGNSS
     RRRQSTAFQL AKDLIRRGSR SYFRQNQENN KDTRVRPPQE FFEPTDLPEI PQNLQPEIFY
     ILHNLKMLEL PSEWKLDPRE IEVRSFQAGD YIVKPGESDD AIYVAIDGEL TVHIRHMEGK
     EYLVKCIPAG GSFFSLLSML DILMDFPSIF RTVALKAADP CRVAKFPITS FRESYHKNPE
     AWIRPIQIVI TRLLHVTLTT LHQYMGLSSE LMRRRRDDDR HRNGSSTSKL QLSLSLKKKE
     KPFNINDNEQ DQLIVARKWM AEAFGLVADD VVSEQIGSKI HLESYEAGHV IIEQGAEEEV
     LMMVLHGNLI LAQYGSDFFA QIERESLFDE ENNEEDESAV IRVTARELVG GLQILTNEPS
     FYTIRAAVQT RVAIMKKKDF SAFLEAHPEI YLPVAHSVLR RLSPFLRGVD FALDWVLVDS
     GHACYRAGDM ADSLFVVLSG RLRSVEKKTV VEEFGRGDVL GMMEVLTKKP RATTVLAVRF
     SQLARVPEGL LNFIKMQYPQ VGFRLVQLLG QYYSQTNRRA PFAAPTVIRT NELGATDPMS
     HIKNLHTIAV VPASPDVPLV PFTCELYHAL SSNLRVLRLS SQKVAACLDP SVLEKQADFR
     LMHWLNVQED TYPLVIYECD FTQTNWTRRC LRQADAILVV AIGGKTPEKQ TLMRELMNMN
     QDGVRTNKEL ILLWPESTKT PSGTIEWLKN SYFSGHHHIR APKRMLQWNR KFRKMSRAEV
     MTPTSVENEV IEYYEKNVFW TPDRRSDFSR LARILTGNAI GLVLGGGGAR GAAHVGVLRA
     LREEGIPVDI VGGTSIGSLI GGLYAETPDD VVVETRAASW FNGMSSLWRK LLDLTYAHSA
     MFTGAQFNFS IKDLFEERLI EDLWISYFCI STDISTSEMR VHRSGPLWAY CRASMSLAGY
     LPPLCDPQDG HLLLDGGYVN NVPADVMRNL GARCVIACDV GSIEETNLYD YGDSLSGMWV
     LLKRLNPFGT PPRILNMEEI QSRLAYVSCV RQLEVVKKAS YCRYLRPPIE PFKTLDFPKF
     QEIMELGLKY GREACHELIT NDRAGILGDE KETRKFKRQQ SRREKPDVSR AVSFTDLAAA
     MSKIPVVRPT LRHSMSLNPS ANGPVGRAGD HFLLDDDLFN DTDYYEEESS QSENGNESFT
     EDEDLVIGPP SSSSSGGNVS ENPRGTTPRP PSS
 
 
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