PLPL_ASPCL
ID PLPL_ASPCL Reviewed; 712 AA.
AC A1CRG6;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Patatin-like phospholipase domain-containing protein ACLA_029670;
DE EC=3.1.1.-;
GN ORFNames=ACLA_029670;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Probable lipid hydrolase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PLPL family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS027059; EAW08237.1; -; Genomic_DNA.
DR RefSeq; XP_001269663.1; XM_001269662.1.
DR AlphaFoldDB; A1CRG6; -.
DR STRING; 5057.CADACLAP00002623; -.
DR EnsemblFungi; EAW08237; EAW08237; ACLA_029670.
DR GeneID; 4700957; -.
DR KEGG; act:ACLA_029670; -.
DR VEuPathDB; FungiDB:ACLA_029670; -.
DR eggNOG; KOG2214; Eukaryota.
DR HOGENOM; CLU_009031_2_2_1; -.
DR OMA; DMNKWLR; -.
DR OrthoDB; 425613at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005811; C:lipid droplet; IEA:EnsemblFungi.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:EnsemblFungi.
DR GO; GO:1990748; P:cellular detoxification; IEA:EnsemblFungi.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006642; P:triglyceride mobilization; IEA:EnsemblFungi.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; SSF52151; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 3: Inferred from homology;
KW Hydrolase; Lipid degradation; Lipid metabolism; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..712
FT /note="Patatin-like phospholipase domain-containing protein
FT ACLA_029670"
FT /id="PRO_0000295549"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 275..466
FT /note="PNPLA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 306..310
FT /note="GXSXG"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT COMPBIAS 649..664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 308
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT ACT_SITE 453
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
SQ SEQUENCE 712 AA; 81401 MW; 2FA3CE0EA03AC030 CRC64;
MTSAEKSATR NIYDPSALPD YDTQFIKPDE LHQFEKALNA PAAAPLVAIN DWRPINQRVR
KNRRTKPRRS KDETREGVLY TVLKWPFLFI VFAWITVLGI AYALTRLYIF LYEQCVTWRG
KRERLRRELS VQTNYRDWLT AAQALDTHLG NQKWKETDEY AYYDHLTINK VVAQLKQARK
AAESEVHNGR SGVSDLPAVE DLCALLEACV KNNFAGVENP RLYSESYSGT KDLVQEYIDE
VQACMQLILD SKQIPAEEKY QHFKHLDTNF GRTALCLSGG ATFAYYHFGV IRALLDNDVL
PEIITGTSGG ALVAALVATR TDEELKQLLV PALAYRIRAC HEGFTTWVWR WWRTGARFDT
VDWARQCSWF CRGSTTFREA YERTGRILNV SCVPSDPHSP TILANYLTSP DCVIWSAVLA
SAAVPGILNP VVLMTKKRDG TLAPYSFGHK WKDGSLRTDI PIKALNLHFN VNFTIVSQVN
PHINLFFFSS RGTVGRPVTH RKGRGWRGGF LGSAIEQYIK LDMNKWLRVL RHLELLPRPL
GQDWSEIWLQ KFSGTITIWP KSIPSDFYHI LSDPSPERLA RMLHVGKQSA FPKIQFIKNR
LKIENTIMQG LQQSSPGGDR VLLPILSRRL QNRAQEHADA MVERLDHSFP ERHSDYKDES
HYTEVSDSLS TNSSRPHTPD ARRGSIFEEM RRQSAVFFDD PDMYGDEDAI AT