PLPL_ASPFU
ID PLPL_ASPFU Reviewed; 712 AA.
AC Q4WJS4;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Patatin-like phospholipase domain-containing protein AFUA_1G04970;
DE EC=3.1.1.-;
GN ORFNames=AFUA_1G04970;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Probable lipid hydrolase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PLPL family. {ECO:0000305}.
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DR EMBL; AAHF01000007; EAL88208.1; -; Genomic_DNA.
DR RefSeq; XP_750246.1; XM_745153.1.
DR AlphaFoldDB; Q4WJS4; -.
DR STRING; 746128.CADAFUBP00000525; -.
DR EnsemblFungi; EAL88208; EAL88208; AFUA_1G04970.
DR GeneID; 3507440; -.
DR KEGG; afm:AFUA_1G04970; -.
DR eggNOG; KOG2214; Eukaryota.
DR HOGENOM; CLU_009031_2_2_1; -.
DR InParanoid; Q4WJS4; -.
DR OMA; DMNKWLR; -.
DR OrthoDB; 425613at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005811; C:lipid droplet; IEA:EnsemblFungi.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:EnsemblFungi.
DR GO; GO:1990748; P:cellular detoxification; IEA:EnsemblFungi.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006642; P:triglyceride mobilization; IEA:EnsemblFungi.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; SSF52151; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 3: Inferred from homology;
KW Hydrolase; Lipid degradation; Lipid metabolism; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..712
FT /note="Patatin-like phospholipase domain-containing protein
FT AFUA_1G04970"
FT /id="PRO_0000295550"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 275..466
FT /note="PNPLA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 306..310
FT /note="GXSXG"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT COMPBIAS 628..664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 308
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT ACT_SITE 453
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
SQ SEQUENCE 712 AA; 81948 MW; 02D627455EB89EBB CRC64;
MTSDEKSATR DIYDPNTLPD YDREFIEPDD LRQFEKALNA PEAAPLVALN DWRPVNQRVR
KSRRTKPRRS KDETREGVLY TVLKWPFLFT VFAWITVLGF AYTLTRLYIF LYEQFVTWRG
KREQLRRELS MQTNYQDWLK AAQALDTYLG NLKWKETDEY AYYDHLTINK VVAQLKQTRK
AAEMEMQNGR PGLSDPPAVE ELCFLLEACV KNNFAGVENP RLYSETYSGT KDLVQEYIDE
VHSCIRLVLD SKQISNEDKY QFFKHLDTNF GRTALCLSGG ATFAYYHFGV IRALLDNDVL
PEIITGTSGG ALVAALVATR TDEELKQLLV PALAHRIRAC HEGFTTWVRR WWRTGARFDT
LDWARQCSWF CRGSTTFREA YERTGRILNV SCVPSDPHSP TILANYLTSP DCVIWSAVLA
SAAVPGILNP VVLMTKKRDG TLAPYSFGHK WKDGSLRTDI PIKALNLHFN VNFTIVSQVN
PHINLFFFNS RGSVGRPVTH RKGRGWRGGF LGSAIEQYIK LDMNKWLRVL RHLELLPRPL
GQDWSEIWLQ KFSGTITIWP KSIPSDFYHI LSDPSPERLA RMLHVGKQSA FPKIQFIKNR
LKIENAIMQG LQQCSSGGGR VMSPILSRRR QDRAQEHADR MVERLDQSFP ERQSDYKDES
HYAEVSDSLS ATSSRPHTPD ARRSSMFEEM RRQSAVFFDD PDMYADEDAV TT
