ID   PLPL_ASPTN              Reviewed;         715 AA.
AC   Q0CUP0;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Patatin-like phospholipase domain-containing protein ATEG_02594;
DE            EC=3.1.1.-;
GN   ORFNames=ATEG_02594;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable lipid hydrolase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PLPL family. {ECO:0000305}.
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DR   EMBL; CH476596; EAU37556.1; -; Genomic_DNA.
DR   RefSeq; XP_001211772.1; XM_001211772.1.
DR   AlphaFoldDB; Q0CUP0; -.
DR   STRING; 341663.Q0CUP0; -.
DR   EnsemblFungi; EAU37556; EAU37556; ATEG_02594.
DR   GeneID; 4317082; -.
DR   VEuPathDB; FungiDB:ATEG_02594; -.
DR   eggNOG; KOG2214; Eukaryota.
DR   HOGENOM; CLU_009031_2_2_1; -.
DR   OMA; DMNKWLR; -.
DR   OrthoDB; 425613at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005811; C:lipid droplet; IEA:EnsemblFungi.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:EnsemblFungi.
DR   GO; GO:1990748; P:cellular detoxification; IEA:EnsemblFungi.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006642; P:triglyceride mobilization; IEA:EnsemblFungi.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR021771; Triacylglycerol_lipase_N.
DR   Pfam; PF11815; DUF3336; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; SSF52151; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Lipid degradation; Lipid metabolism; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..715
FT                   /note="Patatin-like phospholipase domain-containing protein
FT                   ATEG_02594"
FT                   /id="PRO_0000295553"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          274..465
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   REGION          613..715
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           305..309
FT                   /note="GXSXG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   COMPBIAS        616..632
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        645..659
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        663..677
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        307
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   ACT_SITE        452
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
SQ   SEQUENCE   715 AA;  81860 MW;  0393760CDA12C717 CRC64;
     MTDSAIGNVY DPRALPDYDR EFIHPDDLRR FENALNDQDV LPLVALNDWR PVYQRVRKTR
     GRRKEPRRTK DETREGVLYT VLKWPFLAFV LGWISFLGVA YILTRFYIFI YEQWVSWRGK
     RQSLRKQLYV QTNYRDWLKA AEALDAHLGN HAWKEIDENA YYDHITINKL VSQLRKLRQD
     AEWEMHHEQV NAAESPAVEE LCTILEACVK NNFAGVENPR LYSETYSGTK VLVQEYVDEV
     KACLELVAES KQISDEDKYH HFKHLDTNFG RTALCLSGGA TFAYYHFGVV RALLDNNVLP
     EIITGTSGGA LVAALVATRT DEELKQLLVP ALAHRIRACH EGFTTWVRRW WRTGARFDTL
     EWARQCSWFC RGSTTFREAY ERTGRILNVS CVPSDPHSPT ILANYLTSPN CVIWSAVLAS
     AAVPGILNPV VLMTKKRDGT LAPYSFGHKW KDGSLRTDIP IKALNLHFNV NFTIVSQVNP
     HINLFFFSSR GAVGRPVTHR KGRGWRGGFL GSAIEQYIKL DMNKWLRVLR HLELLPRPMG
     QDWSEIWLQK FSGTVTIWPK TVPSDFYYIL SDPTPERLAR MIHMGQQSAF PKIQFIKNRL
     KIEYAIIKGL QQTAPRGGGR ATSPTQLRLR NGHGNGPVNP IDERLDQNLP ERTGEYSKEA
     DANSAEMSDS SGVDSATASA LREARHPRRN SMLVEMQRQS AVFFDDVDSD TWKGQ