PLPL_CRYNJ
ID PLPL_CRYNJ Reviewed; 871 AA.
AC P0CP52; Q55SE8; Q5KGU2;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 42.
DE RecName: Full=Patatin-like phospholipase domain-containing protein CNE02340;
DE EC=3.1.1.-;
GN OrderedLocusNames=CNE02340;
OS Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS MYA-565) (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=214684;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JEC21 / ATCC MYA-565;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Probable lipid hydrolase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PLPL family. {ECO:0000305}.
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DR EMBL; AE017345; AAW43621.1; -; Genomic_DNA.
DR RefSeq; XP_570928.1; XM_570928.1.
DR AlphaFoldDB; P0CP52; -.
DR STRING; 5207.AAW43621; -.
DR PaxDb; P0CP52; -.
DR eggNOG; KOG2214; Eukaryota.
DR HOGENOM; CLU_009031_2_1_1; -.
DR InParanoid; P0CP52; -.
DR OMA; EPRANIN; -.
DR OrthoDB; 425613at2759; -.
DR Proteomes; UP000002149; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; SSF52151; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 3: Inferred from homology;
KW Hydrolase; Lipid degradation; Lipid metabolism; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..871
FT /note="Patatin-like phospholipase domain-containing protein
FT CNE02340"
FT /id="PRO_0000295557"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 243..435
FT /note="PNPLA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT REGION 20..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 760..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 274..278
FT /note="GXSXG"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT COMPBIAS 20..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..639
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 276
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT ACT_SITE 422
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
SQ SEQUENCE 871 AA; 96720 MW; 395047F7230C13F2 CRC64;
MPPSPPSSAA ADQWNIDYVN EDSPLSPRSF SLPPESPQLS TASPIHQRVS RKRQRATSQG
LTYNVIRWPL LFFIFFIIYL EFSAYVITRQ IVNIFEWLVA WRGYKAKLRK ELRKAKTYDE
WVNTAKKLDK HLGFDDWKDV EEDSYFDWAL VRRVRRTLTR LRAANDTRGL MDALAVCVRA
NFAGTESVKM YSETFIGTKK AVEAHIKEVA ACLDYVRTAT DVSLEEKRAF FRAVNKHYGS
SALCLSGGAS FGYYHFGVIK AFLEADLLPR VITGTSAGGL CAALLCTRTD SELKELLVPE
LADKITACSD PFTVWFKRFR QTGARFDTID WARRSMWFTR GSLTFKEAYT KTGRALNISV
VPSDRHSPTI LLNHLTAPNC LIWSAILASA AVPGILNPVV LMAKDRSGNI KPHNLGGSRF
KDGSLREDIP LGSLHTQFNC NFSIVSQTNP HIHLFFFAPR GSVGRPVAHR KGKGWRGGFI
LSALESYIKL DLSKHFKVIR DLDLMPQILQ SDWSGVFLQR FSGDLTLTPR STIGDWFHIL
SDPDRPQMKR MLRVGERVAW PALGMVRNRM TVERAILRGR SEVRTALSHD RTSNDPATSL
PETNPELTGA LDHVPIESDV DAGFVSRSRR ARNKTGSKGG DTPEEQLNLA GVFQLDESSK
GVRRRKQKKS GMPLVAEPLG ELPEVSPTHS PIATESPQRN YTSNFGDSFR HVRAPSLPAL
SSPFRSIRSN TSSSSNNVQS PSSSQRFRSQ LSITRWFGGV SESSSDEEDE DLGGLQSGEA
TASSGEEGIP TFQLDSAVES HSDRSEDEML HSGANVKEEY QSEESEGKIP IPGGERVTQE
KIDSSMASGE RLRPAGGSKG SAKTPPVQDG A
