PLPL_DEBHA
ID PLPL_DEBHA Reviewed; 788 AA.
AC Q6BXC8;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Patatin-like phospholipase domain-containing protein DEHA2B04136g;
DE EC=3.1.1.-;
GN OrderedLocusNames=DEHA2B04136g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Probable lipid hydrolase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PLPL family. {ECO:0000305}.
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DR EMBL; CR382134; CAG85135.2; -; Genomic_DNA.
DR RefSeq; XP_457141.2; XM_457141.1.
DR AlphaFoldDB; Q6BXC8; -.
DR STRING; 4959.XP_457141.2; -.
DR EnsemblFungi; CAG85135; CAG85135; DEHA2B04136g.
DR GeneID; 2913031; -.
DR KEGG; dha:DEHA2B04136g; -.
DR VEuPathDB; FungiDB:DEHA2B04136g; -.
DR eggNOG; KOG2214; Eukaryota.
DR HOGENOM; CLU_009031_2_2_1; -.
DR InParanoid; Q6BXC8; -.
DR OMA; DMNKWLR; -.
DR OrthoDB; 425613at2759; -.
DR Proteomes; UP000000599; Chromosome B.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; SSF52151; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 3: Inferred from homology;
KW Hydrolase; Lipid degradation; Lipid metabolism; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..788
FT /note="Patatin-like phospholipase domain-containing protein
FT DEHA2B04136g"
FT /id="PRO_0000295558"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 311..503
FT /note="PNPLA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT REGION 662..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 342..346
FT /note="GXSXG"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT COMPBIAS 662..676
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..702
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..721
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..745
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 344
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT ACT_SITE 490
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
SQ SEQUENCE 788 AA; 90454 MW; 7FB35C3D4BE23BB0 CRC64;
MEKTNRKKLF DEDIDYVNED HISSFAKALA WEEQYEILEN EKSGASSDKE SQDAATIQKE
TEELDDLGAD ELSTALNGMH KPDLISSKSD WWPINTSKSI PKTKIRKKSK KSSVNEGHSK
ITNEFRSSAS YTMLRWPILI FISCWISLLC FMYIIVRAYV ALSEYFLTWV GKRKELRNKL
RASQNYEEWV QNALELDRFL NLDKWSENPK FSYYDSKTVE LTISKLASLR EEGRDNDLMV
ILQGCIKKNF AGIENRQLYS HRYYGTKYLV EKYIDEVIVC IDKVIESQQI SFNDKRRFFR
TVSKNYGKTA LCLSGGACFT YTHFGIVKAL LDNDLLPSII SGTSGGGLIA ALSCTRTDDE
LKKLLVPELA RKITACEDPW YVWIPRWWRT GARFDSLEWA RKANFFTRGS TTFYESFKRT
GRRLNISTVP SNPHSPVILC NNITSPNCII WSSLLASSAV PGILNPVVLL MKDLKTDRVV
PFSLGSKWRD GSLRTDIPID ALNTYYNVNF SIVSQVNPHI SLFFFAPKGT VGRPVAIPRR
KTHKEKYASL RGGFIATALE QLFKLEITKW LQMIKSLDLL PHLLEQDWSN IWLQRFSGSI
TIWPRNRLKD FWYILSDPTE ERLAEMLSKG ERAMFPRILF VKHRLSIEKA IEKGRKQTKL
SANFNTLTSS DSGRTELSPE AAELQVEPAM FDDDEYDSDS SDDEVLSPNN KKHIDKFGTP
NTEDGDDDED AYEYYDDDDY GLSTEDEANQ ENTGNSQGEE NDTGSRFLKS FFRAGSRDSK
LHRRNTVF
