PLPL_MAGO7
ID PLPL_MAGO7 Reviewed; 787 AA.
AC A4R8V2; G4N7U1;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Patatin-like phospholipase domain-containing protein MGG_12849;
DE EC=3.1.1.-;
GN ORFNames=MGG_12849;
OS Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS fungus) (Pyricularia oryzae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX NCBI_TaxID=242507;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX PubMed=15846337; DOI=10.1038/nature03449;
RA Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL Nature 434:980-986(2005).
CC -!- FUNCTION: Probable lipid hydrolase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PLPL family. {ECO:0000305}.
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DR EMBL; CM001234; EHA50895.1; -; Genomic_DNA.
DR RefSeq; XP_003717214.1; XM_003717166.1.
DR AlphaFoldDB; A4R8V2; -.
DR STRING; 318829.MGG_12849T0; -.
DR EnsemblFungi; MGG_12849T0; MGG_12849T0; MGG_12849.
DR GeneID; 5050218; -.
DR KEGG; mgr:MGG_12849; -.
DR VEuPathDB; FungiDB:MGG_12849; -.
DR eggNOG; KOG2214; Eukaryota.
DR HOGENOM; CLU_009031_2_0_1; -.
DR InParanoid; A4R8V2; -.
DR OMA; DMNKWLR; -.
DR OrthoDB; 425613at2759; -.
DR Proteomes; UP000009058; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; SSF52151; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 3: Inferred from homology;
KW Hydrolase; Lipid degradation; Lipid metabolism; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..787
FT /note="Patatin-like phospholipase domain-containing protein
FT MGG_12849"
FT /id="PRO_0000295561"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 375..566
FT /note="PNPLA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT REGION 47..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 406..410
FT /note="GXSXG"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT COMPBIAS 144..160
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 408
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT ACT_SITE 553
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
SQ SEQUENCE 787 AA; 88461 MW; DAD66CE20AB01316 CRC64;
MTEKQINVPA RAYGFPPDAY DPSLLPDFDV SFLRPEDLEA FIQALSAPDT TQPPDDGLAS
PRSPSARSFS SFDFTKRASS VLPDDAQVVA AHAAAAGGET APIPGDNDTN NANGFGNSSS
QSLFITAQSD WAPVHEKVVG SQTHRQKKSS RRRKRSKAVA PGRRTRDETR EGYLYGLLKW
PFLLIVGAWI VGLAVTYLFT RAYIFIYEQF VAWRGRREKL RRNMRATSRY PDWVKAARDL
DNFLGNEAWK EQNEFAYYDS KTVRRVWDSL RRSRIRAAQM EASGSQSSSS SNEGKTTPIE
DLKVLIEACV KNNFVGVENP RLYSQTYYGT KNLVQNYVDE VEKSLTALLE TKQLSMEDKR
SIFKRVSANY GRTALCLSGG ASFAYYHFGV VKALLEEDLL PDVITGTSGG ALVAALVATR
TNEELKKLLV PSLSTKITAC REPITVWFRR WWSTGARFDS VDWAKQCSWW SHGSMTFREA
YERTGRILNV SCVPADPHSP TILCNYLTSP DCVIWSAVLA SAAVPGILNP VVLMMKKADG
NLAPYSFGHK WKDGSLRTDI PIRALNLQFN VNFTIVSQVN PHINLFFFSS RGSVGQPVTH
RRGRGWRGGF LGSATEQYIK LDLTKWLKVL RQLELLPRPL GQDWSQLWLQ QSFGGTVTIW
PKTILSDFVH ILSDPDNARL ARMIHEGQQS TFPKIKFISN RLRIERLIER GRRETRPYIR
RGSVESIISE DDLRELLLLR GSTNGTDEEI TTNDEMEFAS DEKAVLTEDE GQFDGVTDNT
EGSPLLK