ID   PLPL_NEUCR              Reviewed;         870 AA.
AC   P0C584; A7UVU6; Q7RYS8;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Patatin-like phospholipase domain-containing protein NCU11180;
DE            EC=3.1.1.-;
GN   ORFNames=NCU00381, NCU11180;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Probable lipid hydrolase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PLPL family. {ECO:0000305}.
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DR   EMBL; CM002238; EDO65416.1; -; Genomic_DNA.
DR   RefSeq; XP_001728507.1; XM_001728455.2.
DR   AlphaFoldDB; P0C584; -.
DR   STRING; 5141.EFNCRP00000000213; -.
DR   EnsemblFungi; EDO65416; EDO65416; NCU11180.
DR   GeneID; 5847897; -.
DR   KEGG; ncr:NCU11180; -.
DR   VEuPathDB; FungiDB:NCU11180; -.
DR   HOGENOM; CLU_009031_2_0_1; -.
DR   InParanoid; P0C584; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR021771; Triacylglycerol_lipase_N.
DR   Pfam; PF11815; DUF3336; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; SSF52151; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Lipid degradation; Lipid metabolism; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..870
FT                   /note="Patatin-like phospholipase domain-containing protein
FT                   NCU11180"
FT                   /id="PRO_0000295563"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          399..590
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          131..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          281..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          735..786
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          804..870
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           430..434
FT                   /note="GXSXG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   COMPBIAS        290..319
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        848..870
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        432
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
FT   ACT_SITE        577
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01161"
SQ   SEQUENCE   870 AA;  97489 MW;  0A3109CA8232740C CRC64;
     MADDTDNPPN IQIPAKSYGF PPEAFDPRRL PDYDTNFLPA HDLEAFIQAL AAPDFVQSPD
     DASSMRLNSP GLHSPSSLDI TKDDYDHSEA RAALASVADV AAPGGGNNHH RRTSTGTFFS
     AHNDWAPVSE KVIKTDRDEK RNKRGKDRKN KKPRKGVAPL RTLVGTRSKD ETREGYLYSL
     LKWPFLLFVS FWIVGLGMAY LATRFYIYFY EQFVAWRGRR EQLRRAMRAT GNYKDWVAAA
     RNMDDFFGNQ RWKEENDFAY YDSKTVRRVW DQMRRCREKA EEVERELESQ SQNSDSGVAS
     GEETSNTKAG GGNNGNDKKT QPVEDLKALI EACVKNNFVG IENPRLYSQT YYGTKNLVQN
     YVDEVERSIK FLIDTKQLTK EQKRVMFKGI CANYGRTALC LSGGATFAYY HFGVVKALLE
     VDYLPDIITG TSGGALVAAL VATRTNDELK ELLNPALAHK ITACRESFTV WFWRWWKTGA
     RFDSVDWAKQ CAWWCHGSLT FREAYERTGR ILNVSCVPSD PHSPTILCNY LTSPDCVIWS
     AVLASAAVPG ILNPVVLMMK NRDGSLEPYS FGHKWKDGSL RTDIPIKSLN LHFNVNFSIV
     SQVNPHINLF FFSSRGSVGQ PVTHRKGRGW RGGYLGSATE QYIKLDLTKW LRVLRQLELL
     PRPLGQDWSQ LWLQTFGGTV TIWPKSIPSD FLKILSDPDP PRLARMIHEG QQSAFPKVKF
     IANRLKIERL VERGRRETRD RRNAANAFTA TGDGEGSYAS HSIVDAMGGK HPLAPSSSGG
     AGDRRGSIES ILSEDDLRSL LIKGREGVHT SGGSSTGTED ELTMTELEGE DDDGGTSRVS
     EGGSRNRYFE GALEEEDGAL EVAASDHSRT