ID   PLPP7_DANRE             Reviewed;         287 AA.
AC   Q6P0E8;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Inactive phospholipid phosphatase 7 {ECO:0000250|UniProtKB:Q8NBV4};
DE   AltName: Full=Phosphatidic acid phosphatase type 2 domain-containing protein 3;
GN   Name=plpp7 {ECO:0000250|UniProtKB:Q8NBV4}; Synonyms=ppapdc3;
GN   ORFNames=zgc:77336;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role as negative regulator of myoblast
CC       differentiation, in part through effects on MTOR signaling. Has no
CC       detectable enzymatic activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus envelope. Endoplasmic reticulum membrane.
CC       Membrane; Multi-pass membrane protein. Note=Both the N- and C-terminal
CC       are exposed to the cytoplasm/nucleoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase
CC       family. {ECO:0000305}.
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DR   EMBL; BC065648; AAH65648.1; -; mRNA.
DR   RefSeq; NP_991223.1; NM_205660.1.
DR   AlphaFoldDB; Q6P0E8; -.
DR   SMR; Q6P0E8; -.
DR   STRING; 7955.ENSDARP00000101044; -.
DR   PaxDb; Q6P0E8; -.
DR   Ensembl; ENSDART00000162246; ENSDARP00000139196; ENSDARG00000103712.
DR   GeneID; 402958; -.
DR   KEGG; dre:402958; -.
DR   CTD; 402958; -.
DR   ZFIN; ZDB-GENE-040426-1822; plpp7a.
DR   eggNOG; KOG4268; Eukaryota.
DR   GeneTree; ENSGT00940000157147; -.
DR   HOGENOM; CLU_072573_4_0_1; -.
DR   InParanoid; Q6P0E8; -.
DR   OMA; KIHCKFL; -.
DR   OrthoDB; 1356295at2759; -.
DR   PhylomeDB; Q6P0E8; -.
DR   PRO; PR:Q6P0E8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000103712; Expressed in muscle tissue and 27 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0042392; F:sphingosine-1-phosphate phosphatase activity; IBA:GO_Central.
DR   InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR   InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR   Pfam; PF01569; PAP2; 1.
DR   SMART; SM00014; acidPPc; 1.
DR   SUPFAM; SSF48317; SSF48317; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Nucleus; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..287
FT                   /note="Inactive phospholipid phosphatase 7"
FT                   /id="PRO_0000239404"
FT   TOPO_DOM        1..120
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        142..146
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        168..215
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        237..247
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        269..287
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   287 AA;  31668 MW;  E1C7D1A88B98D8C5 CRC64;
     MPANQTRSRA RERNNVLNRP EFMSLNQPIK SGGGGGGGES RGTARRPSQR QQQNQQQQGD
     NPQPENNKDK KELPEEDCMQ LNPSFKGIAM NSLLAIDICM SKRLGVCAHP SSSWGSVRSM
     VKLLALTGHG IPWVFGTIVC LMRSNTLAGQ EVLVNLLLAL LLDVMTVSGM QKLVKRKGPW
     EMPPGFFDYL AMDIYSFPAA HASRAVMVSK FLLAHLVLAV PLRILLVLWA ILVGISRVLL
     GRHHLTDVGC GFALGFLHYS LVEMVWLSSN TCQTLISIGT FNWSPLY