ID   PLPR1_DANRE             Reviewed;         333 AA.
AC   Q6IQH6;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Phospholipid phosphatase-related protein type 1 {ECO:0000250|UniProtKB:Q8TBJ4};
DE   AltName: Full=Inactive 2-lysophosphatidate phosphatase PLPPR1 {ECO:0000250|UniProtKB:Q6WAY2};
DE   AltName: Full=Lipid phosphate phosphatase-related protein type 1 {ECO:0000250|UniProtKB:Q8TBJ4};
GN   Name=plppr1; Synonyms=lppr1 {ECO:0000250|UniProtKB:Q8TBJ4};
GN   ORFNames=zgc:86759;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in neurite outgrowth and neurogenesis.
CC       {ECO:0000250|UniProtKB:Q6WAY2}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6WAY2};
CC       Multi-pass membrane protein {ECO:0000255}. Cell projection, neuron
CC       projection {ECO:0000250|UniProtKB:Q6WAY2}.
CC   -!- SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase
CC       family. {ECO:0000305}.
CC   -!- CAUTION: Has no 2-lysophosphatidate/LPA phosphatase activity. This is
CC       supported by the fact that the phosphatase sequence motifs as well as
CC       the His residue acting as a nucleophile in active phosphatases of the
CC       PA-phosphatase related phosphoesterase family are not conserved.
CC       {ECO:0000250|UniProtKB:Q6WAY2}.
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DR   EMBL; BC071430; AAH71430.1; -; mRNA.
DR   RefSeq; NP_001002132.1; NM_001002132.1.
DR   AlphaFoldDB; Q6IQH6; -.
DR   GeneID; 415222; -.
DR   KEGG; dre:415222; -.
DR   CTD; 54886; -.
DR   ZFIN; ZDB-GENE-040625-138; plppr1.
DR   InParanoid; Q6IQH6; -.
DR   OrthoDB; 1621899at2759; -.
DR   PhylomeDB; Q6IQH6; -.
DR   PRO; PR:Q6IQH6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0042577; F:lipid phosphatase activity; IBA:GO_Central.
DR   GO; GO:0008195; F:phosphatidate phosphatase activity; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR   GO; GO:0046839; P:phospholipid dephosphorylation; IBA:GO_Central.
DR   GO; GO:0006644; P:phospholipid metabolic process; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR028678; LPPR1.
DR   InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR   InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR   InterPro; IPR043216; PA_PP_rel.
DR   PANTHER; PTHR10165; PTHR10165; 1.
DR   PANTHER; PTHR10165:SF41; PTHR10165:SF41; 1.
DR   Pfam; PF01569; PAP2; 1.
DR   SMART; SM00014; acidPPc; 1.
DR   SUPFAM; SSF48317; SSF48317; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..333
FT                   /note="Phospholipid phosphatase-related protein type 1"
FT                   /id="PRO_0000317535"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        200..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        162
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   333 AA;  36492 MW;  3E4C4FA92A6F43A6 CRC64;
     MASDNTHRSY SIIPCFIFVE LVIMAGTVLL AYYFECTDTF GIHIQGFFCN DADLLKPYPG
     PEESSFIQPL ILYCVVAAAP TAIIFVGEIS MYIMKSTGEA LLAQEKTIVT GECCYLNPLI
     RRIIRFIGVF AFGLFATDIF VNAGQVVTGN LAPYFLNVCK PNYTGLDCHF SHQFIANGNI
     CTGNQVVVER ARRSFPSKDA SLSVYSAVYV TMYITSTIKT KSSRLAKPVL CLGLLCAAFL
     TGLNRVSEYR NHCSDVVAGF ILGSSIALFL GICVVNNFKG THSTPTKQKQ EDYRGLPLMT
     FPRVESPLET LSAQGKSCQA TLLTSSQPNT WSA