PLPR1_HUMAN
ID PLPR1_HUMAN Reviewed; 325 AA.
AC Q8TBJ4; Q5VX23; Q9NXE2;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Phospholipid phosphatase-related protein type 1 {ECO:0000305};
DE AltName: Full=Inactive 2-lysophosphatidate phosphatase PLPPR1 {ECO:0000250|UniProtKB:Q6WAY2};
DE AltName: Full=Lipid phosphate phosphatase-related protein type 1 {ECO:0000303|Ref.2};
DE AltName: Full=Plasticity-related gene 3 protein {ECO:0000305|PubMed:14750979};
DE Short=PRG-3 {ECO:0000303|PubMed:14750979};
GN Name=PLPPR1 {ECO:0000312|HGNC:HGNC:25993};
GN Synonyms=LPPR1 {ECO:0000303|Ref.2}, PRG3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14750979; DOI=10.1046/j.1460-9568.2003.03078.x;
RA Savaskan N.E., Brauer A.U., Nitsch R.;
RT "Molecular cloning and expression regulation of PRG-3, a new member of the
RT plasticity-related gene family.";
RL Eur. J. Neurosci. 19:212-220(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Morris A.J., Sigal Y.J., McDermott M., Sciorra V.A.;
RT "Lipid phosphate phosphatase related proteins.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in neurite outgrowth and neurogenesis.
CC {ECO:0000250|UniProtKB:Q6WAY2}.
CC -!- INTERACTION:
CC Q8TBJ4; P23560-2: BDNF; NbExp=3; IntAct=EBI-18063495, EBI-12275524;
CC Q8TBJ4; P28799: GRN; NbExp=3; IntAct=EBI-18063495, EBI-747754;
CC Q8TBJ4; O60333-2: KIF1B; NbExp=3; IntAct=EBI-18063495, EBI-10975473;
CC Q8TBJ4; O15243: LEPROT; NbExp=3; IntAct=EBI-18063495, EBI-15672507;
CC Q8TBJ4; P16284: PECAM1; NbExp=3; IntAct=EBI-18063495, EBI-716404;
CC Q8TBJ4; O43933: PEX1; NbExp=3; IntAct=EBI-18063495, EBI-988601;
CC Q8TBJ4; P26678: PLN; NbExp=3; IntAct=EBI-18063495, EBI-692836;
CC Q8TBJ4; P60891: PRPS1; NbExp=3; IntAct=EBI-18063495, EBI-749195;
CC Q8TBJ4; P54725: RAD23A; NbExp=3; IntAct=EBI-18063495, EBI-746453;
CC Q8TBJ4; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-18063495, EBI-10329948;
CC Q8TBJ4; P50454: SERPINH1; NbExp=3; IntAct=EBI-18063495, EBI-350723;
CC Q8TBJ4; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-18063495, EBI-8644112;
CC Q8TBJ4; P37173: TGFBR2; NbExp=3; IntAct=EBI-18063495, EBI-296151;
CC Q8TBJ4; Q6ZT21: TMPPE; NbExp=3; IntAct=EBI-18063495, EBI-11724433;
CC Q8TBJ4; O76024: WFS1; NbExp=3; IntAct=EBI-18063495, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6WAY2};
CC Multi-pass membrane protein {ECO:0000255}. Cell projection, neuron
CC projection {ECO:0000250|UniProtKB:Q6WAY2}.
CC -!- SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase
CC family. {ECO:0000305}.
CC -!- CAUTION: Has no 2-lysophosphatidate/LPA phosphatase activity. This is
CC supported by the fact that the phosphatase sequence motifs as well as
CC the His residue acting as a nucleophile in active phosphatases of the
CC PA-phosphatase related phosphoesterase family are not conserved.
CC {ECO:0000250|UniProtKB:Q6WAY2}.
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DR EMBL; AY337718; AAQ73539.1; -; mRNA.
DR EMBL; AY304515; AAP72152.1; -; mRNA.
DR EMBL; AK000307; BAA91072.1; -; mRNA.
DR EMBL; AL359893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL161631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471105; EAW58938.1; -; Genomic_DNA.
DR EMBL; BC022465; AAH22465.1; -; mRNA.
DR CCDS; CCDS6751.1; -.
DR RefSeq; NP_060223.2; NM_017753.2.
DR RefSeq; NP_997182.1; NM_207299.1.
DR AlphaFoldDB; Q8TBJ4; -.
DR BioGRID; 120234; 19.
DR IntAct; Q8TBJ4; 23.
DR STRING; 9606.ENSP00000364008; -.
DR DEPOD; PLPPR1; -.
DR GlyGen; Q8TBJ4; 3 sites.
DR iPTMnet; Q8TBJ4; -.
DR PhosphoSitePlus; Q8TBJ4; -.
DR BioMuta; PLPPR1; -.
DR DMDM; 74751381; -.
DR MassIVE; Q8TBJ4; -.
DR PaxDb; Q8TBJ4; -.
DR PeptideAtlas; Q8TBJ4; -.
DR PRIDE; Q8TBJ4; -.
DR ProteomicsDB; 74019; -.
DR ABCD; Q8TBJ4; 3 sequenced antibodies.
DR Antibodypedia; 14633; 46 antibodies from 10 providers.
DR DNASU; 54886; -.
DR Ensembl; ENST00000374874.8; ENSP00000364008.3; ENSG00000148123.15.
DR Ensembl; ENST00000395056.2; ENSP00000378496.1; ENSG00000148123.15.
DR Ensembl; ENST00000611695.4; ENSP00000478338.1; ENSG00000276539.4.
DR Ensembl; ENST00000614834.2; ENSP00000477959.1; ENSG00000276539.4.
DR GeneID; 54886; -.
DR KEGG; hsa:54886; -.
DR MANE-Select; ENST00000374874.8; ENSP00000364008.3; NM_207299.2; NP_997182.1.
DR UCSC; uc004bbb.4; human.
DR CTD; 54886; -.
DR DisGeNET; 54886; -.
DR GeneCards; PLPPR1; -.
DR HGNC; HGNC:25993; PLPPR1.
DR HPA; ENSG00000148123; Tissue enhanced (brain, choroid plexus, kidney).
DR MIM; 619590; gene.
DR neXtProt; NX_Q8TBJ4; -.
DR OpenTargets; ENSG00000148123; -.
DR VEuPathDB; HostDB:ENSG00000148123; -.
DR eggNOG; KOG3030; Eukaryota.
DR GeneTree; ENSGT00940000158875; -.
DR HOGENOM; CLU_021458_1_0_1; -.
DR InParanoid; Q8TBJ4; -.
DR OMA; GEISMYV; -.
DR OrthoDB; 1621899at2759; -.
DR PhylomeDB; Q8TBJ4; -.
DR BRENDA; 3.1.3.4; 2681.
DR PathwayCommons; Q8TBJ4; -.
DR Reactome; R-HSA-419408; Lysosphingolipid and LPA receptors.
DR SignaLink; Q8TBJ4; -.
DR SIGNOR; Q8TBJ4; -.
DR BioGRID-ORCS; 54886; 11 hits in 1016 CRISPR screens.
DR ChiTaRS; PLPPR1; human.
DR GenomeRNAi; 54886; -.
DR Pharos; Q8TBJ4; Tdark.
DR PRO; PR:Q8TBJ4; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8TBJ4; protein.
DR Bgee; ENSG00000148123; Expressed in cortical plate and 76 other tissues.
DR ExpressionAtlas; Q8TBJ4; baseline and differential.
DR Genevisible; Q8TBJ4; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0042577; F:lipid phosphatase activity; IBA:GO_Central.
DR GO; GO:0008195; F:phosphatidate phosphatase activity; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR GO; GO:0046839; P:phospholipid dephosphorylation; IBA:GO_Central.
DR GO; GO:0006644; P:phospholipid metabolic process; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR028678; LPPR1.
DR InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR InterPro; IPR043216; PA_PP_rel.
DR PANTHER; PTHR10165; PTHR10165; 1.
DR PANTHER; PTHR10165:SF41; PTHR10165:SF41; 1.
DR Pfam; PF01569; PAP2; 1.
DR SMART; SM00014; acidPPc; 1.
DR SUPFAM; SSF48317; SSF48317; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell projection; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..325
FT /note="Phospholipid phosphatase-related protein type 1"
FT /id="PRO_0000317532"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 307
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8BFZ2"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 316
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 105
FT /note="Q -> R (in Ref. 3; BAA91072)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 325 AA; 35795 MW; 5FC7B9381B78D116 CRC64;
MAVGNNTQRS YSIIPCFIFV ELVIMAGTVL LAYYFECTDT FQVHIQGFFC QDGDLMKPYP
GTEEESFITP LVLYCVLAAT PTAIIFIGEI SMYFIKSTRE SLIAQEKTIL TGECCYLNPL
LRRIIRFTGV FAFGLFATDI FVNAGQVVTG HLTPYFLTVC KPNYTSADCQ AHHQFINNGN
ICTGDLEVIE KARRSFPSKH AALSIYSALY ATMYITSTIK TKSSRLAKPV LCLGTLCTAF
LTGLNRVSEY RNHCSDVIAG FILGTAVALF LGMCVVHNFK GTQGSPSKPK PEDPRGVPLM
AFPRIESPLE TLSAQNHSAS MTEVT
