ID   PLPR1_XENTR             Reviewed;         325 AA.
AC   A4II83;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Phospholipid phosphatase-related protein type 1 {ECO:0000250|UniProtKB:Q8TBJ4};
DE   AltName: Full=Inactive 2-lysophosphatidate phosphatase PLPPR1 {ECO:0000250|UniProtKB:Q6WAY2};
DE   AltName: Full=Lipid phosphate phosphatase-related protein type 1 {ECO:0000250|UniProtKB:Q8TBJ4};
GN   Name=plppr1 {ECO:0000250|UniProtKB:Q8TBJ4}; Synonyms=lppr1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in neurite outgrowth and neurogenesis.
CC       {ECO:0000250|UniProtKB:Q6WAY2}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6WAY2};
CC       Multi-pass membrane protein {ECO:0000255}. Cell projection, neuron
CC       projection {ECO:0000250|UniProtKB:Q6WAY2}.
CC   -!- SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase
CC       family. {ECO:0000305}.
CC   -!- CAUTION: Has no 2-lysophosphatidate/LPA phosphatase activity. This is
CC       supported by the fact that the phosphatase sequence motifs as well as
CC       the His residue acting as a nucleophile in active phosphatases of the
CC       PA-phosphatase related phosphoesterase family are not conserved.
CC       {ECO:0000250|UniProtKB:Q6WAY2}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC135902; AAI35903.1; -; mRNA.
DR   RefSeq; NP_001096370.1; NM_001102900.1.
DR   RefSeq; XP_012820263.1; XM_012964809.2.
DR   AlphaFoldDB; A4II83; -.
DR   STRING; 8364.ENSXETP00000061844; -.
DR   PaxDb; A4II83; -.
DR   DNASU; 100124964; -.
DR   Ensembl; ENSXETT00000066366; ENSXETP00000061844; ENSXETG00000033877.
DR   GeneID; 100124964; -.
DR   KEGG; xtr:100124964; -.
DR   CTD; 54886; -.
DR   Xenbase; XB-GENE-974061; plppr1.
DR   eggNOG; KOG3030; Eukaryota.
DR   HOGENOM; CLU_021458_1_0_1; -.
DR   InParanoid; A4II83; -.
DR   OMA; GEISMYV; -.
DR   OrthoDB; 1621899at2759; -.
DR   PhylomeDB; A4II83; -.
DR   TreeFam; TF316040; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000033877; Expressed in brain and 2 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0042577; F:lipid phosphatase activity; IBA:GO_Central.
DR   GO; GO:0008195; F:phosphatidate phosphatase activity; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR   GO; GO:0046839; P:phospholipid dephosphorylation; IBA:GO_Central.
DR   GO; GO:0006644; P:phospholipid metabolic process; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR028678; LPPR1.
DR   InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR   InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR   InterPro; IPR043216; PA_PP_rel.
DR   PANTHER; PTHR10165; PTHR10165; 1.
DR   PANTHER; PTHR10165:SF41; PTHR10165:SF41; 1.
DR   Pfam; PF01569; PAP2; 1.
DR   SMART; SM00014; acidPPc; 1.
DR   SUPFAM; SSF48317; SSF48317; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..325
FT                   /note="Phospholipid phosphatase-related protein type 1"
FT                   /id="PRO_0000317536"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        163
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        316
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   325 AA;  36042 MW;  D5E17179C6375A89 CRC64;
     MALETNTHRS YSIIPCFIFV ELVIMAGTVL LSYYFECTDT FQVHIQGFFC QDGNLMKPYP
     GTEDESFISP LVLYCVLAAT PTAIIFIGEV TTYFIKSTRE NLIVQEKMIL TGECCYLNPL
     FRRIIRFIGV FAFGLFATDI FVNAGQVVTG NLTPYFLTVC KPNYTASDCL IYHQFINSAN
     ICTGDPEVIE KARRSFPSKH AALSIYSALY ATMYITSTIK TKSSRLAKPV LCLGTLCCAF
     LTGLNRVSEY RNHCVDVIGG FILGTAIALF LGLCVVHNFK GLYGAQCKPK PEDPRGVPLM
     AFPRVESPLE TLSAQNHSSS MTEVT