PLPR4_HUMAN
ID PLPR4_HUMAN Reviewed; 763 AA.
AC Q7Z2D5; E7EPS1; O75043; Q5T9R9; Q86XQ5; Q8N3F1; Q96MP0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Phospholipid phosphatase-related protein type 4 {ECO:0000305};
DE AltName: Full=Brain-specific phosphatidic acid phosphatase-like protein 1 {ECO:0000303|Ref.7};
DE AltName: Full=Inactive 2-lysophosphatidate phosphatase PLPPR4 {ECO:0000305|PubMed:15280885};
DE AltName: Full=Lipid phosphate phosphatase-related protein type 4 {ECO:0000303|Ref.2};
DE AltName: Full=Plasticity-related gene 1 protein {ECO:0000305|PubMed:12730698};
DE Short=PRG-1 {ECO:0000303|PubMed:12730698};
GN Name=PLPPR4 {ECO:0000312|HGNC:HGNC:23496};
GN Synonyms=KIAA0455 {ECO:0000303|PubMed:9455484}, LPPR4 {ECO:0000303|Ref.2},
GN PHP1 {ECO:0000303|Ref.7}, PRG1 {ECO:0000303|PubMed:12730698};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND CAUTION.
RC TISSUE=Brain;
RX PubMed=12730698; DOI=10.1038/nn1052;
RA Braeuer A.U., Savaskan N.E., Kuehn H., Prehn S., Ninnemann O., Nitsch R.;
RT "A new phospholipid phosphatase, PRG-1, is involved in axon growth and
RT regenerative sprouting.";
RL Nat. Neurosci. 6:572-578(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Morris A.J., Sigal Y.J., McDermott M., Sciorra V.A.;
RT "Lipid phosphate phosphatase related proteins.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9455484; DOI=10.1093/dnares/4.5.345;
RA Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D.,
RA Nomura N., Ohara O.;
RT "Characterization of cDNA clones in size-fractionated cDNA libraries from
RT human brain.";
RL DNA Res. 4:345-349(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 15-763 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 24-763 (ISOFORM 1).
RA Ninnemann O., Brauer A.U., Savaskan N., Nitsch R.;
RT "A new brain specific member of the PAP-2 family.";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 111-763 (ISOFORM 1).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [9]
RP CAUTION.
RX PubMed=15280885; DOI=10.1038/nn0804-789a;
RA McDermott M.I., Sigal Y.J., Sciorra V.A., Morris A.J.;
RT "Is PRG-1 a new lipid phosphatase?";
RL Nat. Neurosci. 7:789-789(2004).
RN [10]
RP VARIANT THR-345, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=26671989; DOI=10.15252/emmm.201505677;
RA Vogt J., Yang J.W., Mobascher A., Cheng J., Li Y., Liu X., Baumgart J.,
RA Thalman C., Kirischuk S., Unichenko P., Horta G., Radyushkin K., Stroh A.,
RA Richers S., Sahragard N., Distler U., Tenzer S., Qiao L., Lieb K.,
RA Tuescher O., Binder H., Ferreiros N., Tegeder I., Morris A.J., Gropa S.,
RA Nuernberg P., Toliat M.R., Winterer G., Luhmann H.J., Huai J., Nitsch R.;
RT "Molecular cause and functional impact of altered synaptic lipid signaling
RT due to a prg-1 gene SNP.";
RL EMBO Mol. Med. 8:25-38(2016).
CC -!- FUNCTION: Postsynaptic density membrane protein that indirectly
CC regulates glutamatergic synaptic transmission through lysophosphatidic
CC acid (LPA)-mediated signaling pathways. Binds lysophosphatidic acid
CC (LPA) and mediates its internalization into cells. Could act as
CC receptor or a transporter of this lipid at the post-synaptic membrane
CC (By similarity). Modulates lysophosphatidic acid (LPA) activity in
CC neuron axonal outgrowth during development by attenuating phospholipid-
CC induced axon collapse (By similarity). {ECO:0000250|UniProtKB:Q7TMB7,
CC ECO:0000250|UniProtKB:Q7TME0}.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density membrane
CC {ECO:0000269|PubMed:26671989}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q7Z2D5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z2D5-2; Sequence=VSP_030950, VSP_030951;
CC Name=3;
CC IsoId=Q7Z2D5-3; Sequence=VSP_046784;
CC -!- TISSUE SPECIFICITY: Expressed by glutamatergic neurons (at protein
CC level). {ECO:0000269|PubMed:26671989}.
CC -!- PTM: O-glycosylated. Probably at Ser-346.
CC {ECO:0000250|UniProtKB:Q7TME0}.
CC -!- SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase
CC family. {ECO:0000305}.
CC -!- CAUTION: Originally described as a 2-lysophosphatidate/LPA phosphatase
CC (PubMed:12730698). However, following studies suggested it does not
CC have such activity or only a residual one (PubMed:15280885). This is
CC further supported by the fact that the phosphatase sequence motifs as
CC well as the His residue acting as a nucleophile in active phosphatases
CC of the PA-phosphatase related phosphoesterase family are not conserved
CC (PubMed:15280885). {ECO:0000269|PubMed:12730698,
CC ECO:0000269|PubMed:15280885}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA32300.3; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=EAW72991.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF541281; AAP57770.1; -; mRNA.
DR EMBL; AY304518; AAP72155.1; -; mRNA.
DR EMBL; AB007924; BAA32300.3; ALT_INIT; mRNA.
DR EMBL; AK056665; BAB71245.1; -; mRNA.
DR EMBL; AK291369; BAF84058.1; -; mRNA.
DR EMBL; AL136147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL139425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471097; EAW72991.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471097; EAW72992.1; -; Genomic_DNA.
DR EMBL; AF357013; AAO85400.1; -; mRNA.
DR EMBL; AL834390; CAD39052.1; -; mRNA.
DR RefSeq; NP_001159724.1; NM_001166252.1. [Q7Z2D5-3]
DR RefSeq; NP_055654.2; NM_014839.4.
DR AlphaFoldDB; Q7Z2D5; -.
DR BioGRID; 115220; 12.
DR STRING; 9606.ENSP00000359204; -.
DR DEPOD; PLPPR4; -.
DR GlyGen; Q7Z2D5; 9 sites.
DR iPTMnet; Q7Z2D5; -.
DR PhosphoSitePlus; Q7Z2D5; -.
DR BioMuta; PLPPR4; -.
DR DMDM; 74750018; -.
DR jPOST; Q7Z2D5; -.
DR MassIVE; Q7Z2D5; -.
DR PaxDb; Q7Z2D5; -.
DR PeptideAtlas; Q7Z2D5; -.
DR PRIDE; Q7Z2D5; -.
DR ProteomicsDB; 17424; -.
DR ProteomicsDB; 68943; -. [Q7Z2D5-1]
DR ProteomicsDB; 68944; -. [Q7Z2D5-2]
DR Antibodypedia; 1575; 107 antibodies from 25 providers.
DR DNASU; 9890; -.
DR Ensembl; ENST00000370185.9; ENSP00000359204.4; ENSG00000117600.14.
DR Ensembl; ENST00000457765.6; ENSP00000394913.2; ENSG00000117600.14.
DR GeneID; 9890; -.
DR KEGG; hsa:9890; -.
DR UCSC; uc001dse.4; human. [Q7Z2D5-1]
DR CTD; 9890; -.
DR DisGeNET; 9890; -.
DR GeneCards; PLPPR4; -.
DR HGNC; HGNC:23496; PLPPR4.
DR HPA; ENSG00000117600; Tissue enriched (brain).
DR MIM; 607813; gene.
DR neXtProt; NX_Q7Z2D5; -.
DR VEuPathDB; HostDB:ENSG00000117600; -.
DR eggNOG; KOG3030; Eukaryota.
DR HOGENOM; CLU_021458_8_0_1; -.
DR InParanoid; Q7Z2D5; -.
DR OMA; METEPGQ; -.
DR OrthoDB; 1621899at2759; -.
DR PhylomeDB; Q7Z2D5; -.
DR BRENDA; 3.1.3.4; 2681.
DR PathwayCommons; Q7Z2D5; -.
DR Reactome; R-HSA-419408; Lysosphingolipid and LPA receptors.
DR SignaLink; Q7Z2D5; -.
DR BioGRID-ORCS; 9890; 4 hits in 1021 CRISPR screens.
DR ChiTaRS; PLPPR4; human.
DR GenomeRNAi; 9890; -.
DR Pharos; Q7Z2D5; Tbio.
DR PRO; PR:Q7Z2D5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q7Z2D5; protein.
DR Bgee; ENSG00000117600; Expressed in CA1 field of hippocampus and 143 other tissues.
DR Genevisible; Q7Z2D5; HS.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0099061; C:integral component of postsynaptic density membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0098839; C:postsynaptic density membrane; IDA:UniProtKB.
DR GO; GO:0042577; F:lipid phosphatase activity; IBA:GO_Central.
DR GO; GO:0008195; F:phosphatidate phosphatase activity; IBA:GO_Central.
DR GO; GO:0007409; P:axonogenesis; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0048839; P:inner ear development; IEA:Ensembl.
DR GO; GO:0140354; P:lipid import into cell; ISS:UniProtKB.
DR GO; GO:0006644; P:phospholipid metabolic process; IBA:GO_Central.
DR GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR InterPro; IPR000326; P_Acid_Pase_2/haloperoxidase.
DR InterPro; IPR043216; PA_PP_rel.
DR InterPro; IPR028684; PLPPR4.
DR PANTHER; PTHR10165; PTHR10165; 1.
DR PANTHER; PTHR10165:SF13; PTHR10165:SF13; 1.
DR Pfam; PF01569; PAP2; 1.
DR SMART; SM00014; acidPPc; 1.
DR SUPFAM; SSF48317; SSF48317; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Glycoprotein; Membrane;
KW Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Synapse;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..763
FT /note="Phospholipid phosphatase-related protein type 4"
FT /id="PRO_0000317436"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 33..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 458..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 739..754
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 36
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TME0"
FT MOD_RES 346
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TME0"
FT MOD_RES 385
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TMB7"
FT MOD_RES 438
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TME0"
FT MOD_RES 461
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TME0"
FT MOD_RES 472
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TMB7"
FT MOD_RES 606
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7TME0"
FT CARBOHYD 214
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 219
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 362
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 432
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 455
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 513
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 543
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 568
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 265..322
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_046784"
FT VAR_SEQ 552..577
FT /note="SARAKWLKAAEKTVACNRSNSQPRIM -> RVSSKAAPRTLKAARSPALAPS
FT AIKP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030950"
FT VAR_SEQ 578..763
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030951"
FT VARIANT 2
FT /note="Q -> K (in dbSNP:rs712896)"
FT /id="VAR_050618"
FT VARIANT 32
FT /note="A -> V (in dbSNP:rs35285687)"
FT /id="VAR_050619"
FT VARIANT 345
FT /note="R -> T (in dbSNP:rs138327459)"
FT /evidence="ECO:0000269|PubMed:26671989"
FT /id="VAR_085196"
FT CONFLICT 18
FT /note="A -> S (in Ref. 4; BAB71245)"
FT /evidence="ECO:0000305"
FT CONFLICT 718
FT /note="L -> R (in Ref. 8; CAD39052)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 763 AA; 82983 MW; F0401DD5073EBE71 CRC64;
MQRAGSSGGR GECDISGAGR LGLEEAARLS CAVHTSPGGG RRPGQAAGMS AKERPKGKVI
KDSVTLLPCF YFVELPILAS SVVSLYFLEL TDVFKPVHSG FSCYDRSLSM PYIEPTQEAI
PFLMLLSLAF AGPAITIMVG EGILYCCLSK RRNGVGLEPN INAGGCNFNS FLRRAVRFVG
VHVFGLCSTA LITDIIQLST GYQAPYFLTV CKPNYTSLNV SCKENSYIVE DICSGSDLTV
INSGRKSFPS QHATLAAFAA VYVSMYFNST LTDSSKLLKP LLVFTFIICG IICGLTRITQ
YKNHPVDVYC GFLIGGGIAL YLGLYAVGNF LPSDESMFQH RDALRSLTDL NQDPNRLLSA
KNGSSSDGIA HTEGILNRNH RDASSLTNLK RANADVEIIT PRSPMGKENM VTFSNTLPRA
NTPSVEDPVR RNASIHASMD SARSKQLLTQ WKNKNESRKL SLQVIEPEPG QSPPRSIEMR
SSSEPSRVGV NGDHHGPGNQ YLKIQPGAVP GCNNSMPGGP RVSIQSRPGS SQLVHIPEET
QENISTSPKS SSARAKWLKA AEKTVACNRS NSQPRIMQVI AMSKQQGVLQ SSPKNTEGST
VSCTGSIRYK TLTDHEPSGI VRVEAHPENN RPIIQIPSTE GEGSGSWKWK APEKGSLRQT
YELNDLNRDS ESCESLKDSF GSGDRKRSNI DSNEHHHHGI TTIRVTPVEG SEIGSETLSI
SSSRDSTLRR KGNIILIPER SNSPENTRNI FYKGTSPTRA YKD
