ID   PLP_RICPR               Reviewed;         282 AA.
AC   Q9ZCX6;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Parvulin-like PPIase;
DE            EC=5.2.1.8;
DE   AltName: Full=29.5 kDa outer membrane antigen;
DE   AltName: Full=Peptidyl-prolyl cis-trans isomerase plp;
DE   AltName: Full=Rotamase plp;
DE   Flags: Precursor;
GN   Name=plp; OrderedLocusNames=RP576;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC VR-142 / Breinl;
RX   PubMed=10381609;
RA   Emelyanov V.V., Demyanova N.G.;
RT   "Nucleotide sequence of the gene and features of the major outer membrane
RT   protein of a virulent Rickettsia prowazekii strain.";
RL   Biochemistry (Mosc.) 64:494-503(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA   Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA   Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Evir;
RA   Loukianov E.V., Emelyanov V.V.;
RT   "Allelic plp gene from Rickettsia prowazekii Evir strain.";
RL   Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC         peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC         COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC         ChEBI:CHEBI:83834; EC=5.2.1.8;
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PpiC/parvulin rotamase family.
CC       {ECO:0000305}.
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DR   EMBL; AJ235272; CAA15023.1; -; Genomic_DNA.
DR   EMBL; X89470; CAA61657.1; -; Genomic_DNA.
DR   EMBL; AJ279071; CAC10161.1; -; Genomic_DNA.
DR   PIR; E71662; E71662.
DR   RefSeq; NP_220947.1; NC_000963.1.
DR   RefSeq; WP_004597887.1; NC_000963.1.
DR   AlphaFoldDB; Q9ZCX6; -.
DR   SMR; Q9ZCX6; -.
DR   STRING; 272947.RP576; -.
DR   EnsemblBacteria; CAA15023; CAA15023; CAA15023.
DR   GeneID; 57569702; -.
DR   KEGG; rpr:RP576; -.
DR   PATRIC; fig|272947.5.peg.593; -.
DR   eggNOG; COG0760; Bacteria.
DR   HOGENOM; CLU_034646_1_3_5; -.
DR   OMA; YEQAKPT; -.
DR   BRENDA; 5.2.1.8; 5447.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.50.40; -; 1.
DR   InterPro; IPR046357; PPIase_dom_sf.
DR   InterPro; IPR000297; PPIase_PpiC.
DR   PROSITE; PS50198; PPIC_PPIASE_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Isomerase; Membrane; Reference proteome; Rotamase;
KW   Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..282
FT                   /note="Parvulin-like PPIase"
FT                   /id="PRO_0000025545"
FT   DOMAIN          138..231
FT                   /note="PpiC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00278"
SQ   SEQUENCE   282 AA;  31548 MW;  DBB7F316862D3FB4 CRC64;
     MKKLSVIFLS VSMLSSIAFG DEDKVVATYK GGEVKESQIM QEFKPQLNLQ SGETIKNFDD
     FPLQDQEKLI KIYVNNLLLK EEVAKSSITS SKEFQEKLEN AKNQLAQQEL LANYIKSNIT
     DKMFDDEYNK YVDNLKGKEQ IKVAHILVKS QKEANTVKTK LSKGGNFTKL AEEFSLDKAT
     ASNGGIIGYI ILNQPGQLVP EFEQKAFALK VNEVSTPVKT SFGWHIIKVL EKKPVPIPTK
     EEAKVTIDNI LAAEILKQYI SDLEAKADLK IMLPKANSKT GS