PLRG1_BOVIN
ID PLRG1_BOVIN Reviewed; 513 AA.
AC Q2KID6;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Pleiotropic regulator 1;
GN Name=PLRG1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hypothalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in pre-mRNA splicing as component of the
CC spliceosome. Component of the PRP19-CDC5L complex that forms an
CC integral part of the spliceosome and is required for activating pre-
CC mRNA splicing. {ECO:0000250|UniProtKB:O43660}.
CC -!- SUBUNIT: Identified in the spliceosome C complex. Component of the
CC PRP19-CDC5L splicing complex composed of a core complex comprising a
CC homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less
CC stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts (via its
CC WD40 repeat domain) directly with CDC5L (via its C-terminal); the
CC interaction is required for mRNA splicing but not for spliceosome
CC assembly. Also interacts directly in the complex with BCAS2 and PRPF19.
CC Interacts with USB1 (By similarity). {ECO:0000250|UniProtKB:O43660}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43660}. Nucleus
CC speckle {ECO:0000250|UniProtKB:O43660}.
CC -!- SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family. {ECO:0000305}.
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DR EMBL; BC112677; AAI12678.1; -; mRNA.
DR RefSeq; NP_001039827.1; NM_001046362.1.
DR AlphaFoldDB; Q2KID6; -.
DR SMR; Q2KID6; -.
DR STRING; 9913.ENSBTAP00000029840; -.
DR PaxDb; Q2KID6; -.
DR PRIDE; Q2KID6; -.
DR Ensembl; ENSBTAT00000029844; ENSBTAP00000029840; ENSBTAG00000007234.
DR GeneID; 533951; -.
DR KEGG; bta:533951; -.
DR CTD; 5356; -.
DR VEuPathDB; HostDB:ENSBTAG00000007234; -.
DR VGNC; VGNC:33050; PLRG1.
DR eggNOG; KOG0285; Eukaryota.
DR GeneTree; ENSGT00940000155316; -.
DR HOGENOM; CLU_000288_72_2_1; -.
DR InParanoid; Q2KID6; -.
DR OMA; HPLEWKP; -.
DR OrthoDB; 1157847at2759; -.
DR TreeFam; TF105684; -.
DR Proteomes; UP000009136; Chromosome 17.
DR Bgee; ENSBTAG00000007234; Expressed in oocyte and 107 other tissues.
DR ExpressionAtlas; Q2KID6; baseline and differential.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0005662; C:DNA replication factor A complex; IEA:Ensembl.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; ISS:UniProtKB.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0034504; P:protein localization to nucleus; IEA:Ensembl.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR045241; Prp46/PLRG1-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19923; PTHR19923; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Spliceosome; WD repeat.
FT CHAIN 1..513
FT /note="Pleiotropic regulator 1"
FT /id="PRO_0000247544"
FT REPEAT 201..240
FT /note="WD 1"
FT REPEAT 243..282
FT /note="WD 2"
FT REPEAT 285..324
FT /note="WD 3"
FT REPEAT 327..366
FT /note="WD 4"
FT REPEAT 369..409
FT /note="WD 5"
FT REPEAT 410..448
FT /note="WD 6"
FT REPEAT 459..498
FT /note="WD 7"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:O43660"
FT MOD_RES 119
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O43660"
FT MOD_RES 200
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O43660"
FT MOD_RES 390
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O43660"
SQ SEQUENCE 513 AA; 56789 MW; 96423FAA92BCC0E8 CRC64;
MVEEVQKHSV HTLVFRSLKR THDMFVADNG KPVPLDEESH KRKMAIKLRN EYGPVLHMPT
SKENLKEKVP QNASDSYGHK QYPANQGQEV EYLVTGTHPY PPGPGVALTA DTKIQRMPSE
SAAQSLAVAL PASQARADAN RPVPAGGEYR HPGAPDRAQP AGAVVMEGSN AKNSALMAKK
APTMPKPQWH PPWKLYRVIS GHLGWVRCIA VEPGNQWFVT GSADRTIKIW DLASGKLKLS
LTGHISTVRG VIVSTRSPYL FSCGEDKQVK CWDLEYNKVI RHYHGHLSAV YGLDLHPTID
VLVTCSRDST ARIWDVRTKA SVHTLSGHTN AVATVRCQAA EPQIITGSHD TTIRLWDLVA
GKTRVTLTNH KKSVRAVVLH PRHYTFASGS PDNIKQWKFP DGSFIQNLSG HNAIINTLTV
NSDGVLVSGA DNGTMHLWDW RTGYNFQRVH AAVQPGSLDS ESGIFACAFD QSESRLLTAE
ADKTIKVYKE DDTATEETHP VSWKPEIIKR KRF
