PLRKT_HUMAN
ID PLRKT_HUMAN Reviewed; 147 AA.
AC Q9HBL7; B2R6W0; Q9NZ44;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Plasminogen receptor (KT);
DE Short=Plg-R(KT);
GN Name=PLGRKT; Synonyms=C9orf46; ORFNames=AD025, MDS030;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Adrenal gland;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hematopoietic stem cell;
RA Zhao M., Gu J., Li N., Peng Y., Han Z., Chen Z.;
RT "Novel genes expressed in hematopoietic stem/progenitor cells from
RT myelodysplastic syndrome patients.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP FUNCTION IN INFLAMMATORY RESPONSE, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=21940822; DOI=10.1182/blood-2011-03-344242;
RA Lighvani S., Baik N., Diggs J.E., Khaldoyanidi S., Parmer R.J., Miles L.A.;
RT "Regulation of macrophage migration by a novel plasminogen receptor Plg-R
RT KT.";
RL Blood 118:5622-5630(2011).
RN [9]
RP TISSUE SPECIFICITY.
RX PubMed=21795689; DOI=10.1074/jbc.m111.218693;
RA Bai H., Baik N., Kiosses W.B., Krajewski S., Miles L.A., Parmer R.J.;
RT "The novel plasminogen receptor, plasminogen receptor(KT) (Plg-R(KT)),
RT regulates catecholamine release.";
RL J. Biol. Chem. 286:33125-33133(2011).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: Receptor for plasminogen. Regulates urokinase plasminogen
CC activator-dependent and stimulates tissue-type plasminogen activator-
CC dependent cell surface plasminogen activation. Proposed to be part of a
CC local catecholaminergic cell plasminogen activation system that
CC regulates neuroendocrine prohormone processing. Involved in regulation
CC of inflammatory response; regulates monocyte chemotactic migration and
CC matrix metalloproteinase activation, such as of MMP2 and MMP9.
CC {ECO:0000269|PubMed:21940822}.
CC -!- SUBUNIT: Interacts with PLAT and PLAUR. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9HBL7; P26641-2: EEF1G; NbExp=3; IntAct=EBI-714824, EBI-10177695;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21940822};
CC Multi-pass membrane protein {ECO:0000269|PubMed:21940822}.
CC Note=Colocalizes on the cell surface with urokinase plasminogen
CC activator surface receptor/PLAUR. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in peripheral blood cells and monocytes.
CC Expressed in adrenal medulla. {ECO:0000269|PubMed:21795689,
CC ECO:0000269|PubMed:21940822}.
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DR EMBL; AF225420; AAG09722.1; -; mRNA.
DR EMBL; AF220050; AAF67643.1; -; mRNA.
DR EMBL; AK027594; BAB55219.1; -; mRNA.
DR EMBL; AK312736; BAG35607.1; -; mRNA.
DR EMBL; AL135786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471071; EAW58765.1; -; Genomic_DNA.
DR EMBL; BC008212; AAH08212.1; -; mRNA.
DR CCDS; CCDS6463.1; -.
DR RefSeq; NP_060935.2; NM_018465.3.
DR RefSeq; XP_005251567.1; XM_005251510.4.
DR RefSeq; XP_011516262.1; XM_011517960.2.
DR AlphaFoldDB; Q9HBL7; -.
DR BioGRID; 120950; 77.
DR IntAct; Q9HBL7; 146.
DR MINT; Q9HBL7; -.
DR STRING; 9606.ENSP00000223864; -.
DR iPTMnet; Q9HBL7; -.
DR PhosphoSitePlus; Q9HBL7; -.
DR BioMuta; PLGRKT; -.
DR DMDM; 68565305; -.
DR EPD; Q9HBL7; -.
DR jPOST; Q9HBL7; -.
DR MassIVE; Q9HBL7; -.
DR MaxQB; Q9HBL7; -.
DR PaxDb; Q9HBL7; -.
DR PeptideAtlas; Q9HBL7; -.
DR PRIDE; Q9HBL7; -.
DR ProteomicsDB; 81571; -.
DR TopDownProteomics; Q9HBL7; -.
DR Antibodypedia; 2322; 115 antibodies from 23 providers.
DR DNASU; 55848; -.
DR Ensembl; ENST00000223864.7; ENSP00000223864.2; ENSG00000107020.10.
DR GeneID; 55848; -.
DR KEGG; hsa:55848; -.
DR MANE-Select; ENST00000223864.7; ENSP00000223864.2; NM_018465.4; NP_060935.2.
DR UCSC; uc003zjc.5; human.
DR CTD; 55848; -.
DR DisGeNET; 55848; -.
DR GeneCards; PLGRKT; -.
DR HGNC; HGNC:23633; PLGRKT.
DR HPA; ENSG00000107020; Low tissue specificity.
DR MIM; 618444; gene.
DR neXtProt; NX_Q9HBL7; -.
DR OpenTargets; ENSG00000107020; -.
DR PharmGKB; PA134964114; -.
DR VEuPathDB; HostDB:ENSG00000107020; -.
DR eggNOG; KOG4544; Eukaryota.
DR GeneTree; ENSGT00390000000375; -.
DR HOGENOM; CLU_115107_1_0_1; -.
DR InParanoid; Q9HBL7; -.
DR OMA; EANMIME; -.
DR OrthoDB; 1495739at2759; -.
DR PhylomeDB; Q9HBL7; -.
DR TreeFam; TF314698; -.
DR PathwayCommons; Q9HBL7; -.
DR SignaLink; Q9HBL7; -.
DR BioGRID-ORCS; 55848; 9 hits in 1074 CRISPR screens.
DR ChiTaRS; PLGRKT; human.
DR GenomeRNAi; 55848; -.
DR Pharos; Q9HBL7; Tbio.
DR PRO; PR:Q9HBL7; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q9HBL7; protein.
DR Bgee; ENSG00000107020; Expressed in rectum and 162 other tissues.
DR Genevisible; Q9HBL7; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0010756; P:positive regulation of plasminogen activation; IBA:GO_Central.
DR InterPro; IPR019319; Plg-R(KT).
DR PANTHER; PTHR13411; PTHR13411; 1.
DR Pfam; PF10166; DUF2368; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Chemotaxis; Inflammatory response; Membrane;
KW Plasminogen activation; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..147
FT /note="Plasminogen receptor (KT)"
FT /id="PRO_0000089695"
FT TOPO_DOM 1..52
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..147
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CONFLICT 46
FT /note="Q -> R (in Ref. 2; AAF67643)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 147 AA; 17201 MW; BF096D76E8F2F806 CRC64;
MGFIFSKSMN ESMKNQKEFM LMNARLQLER QLIMQSEMRE RQMAMQIAWS REFLKYFGTF
FGLAAISLTA GAIKKKKPAF LVPIVPLSFI LTYQYDLGYG TLLERMKGEA EDILETEKSK
LQLPRGMITF ESIEKARKEQ SRFFIDK
